Cardiac oxidative damage in mice following exposure to nanoparticulate titanium dioxide

Abstract

Nanoparticulate titanium dioxide (nano-TiO2 ) is a widely used powerful nanoparticulate material with high stability, anticorrosion, and photocatalytic property. However, it is possible that during nano-TiO2 exposure, there may be negative effects on cardiovascular system in intoxicated mice. The present study was therefore undertaken to determine nano-TiO2 -induced oxidative stress and to determine whether nano-TiO2 intoxication alters the antioxidant system in the mouse heart exposed to 2.5, 5, and 10 mg/kg body weight nano-TiO2 for 90 consecutive days. The findings showed that long-term exposure to nano-TiO2 resulted in obvious titanium accumulation in heart, in turn led to sparse cardiac muscle fibers, inflammatory response, cell necrosis, and cardiac biochemical dysfunction. Nano-TiO2 exposure promoted remarkably reactive oxygen species production such as superoxide radicals, hydrogen peroxide, and increased malondialdehyde, carbonyl and 8-OHdG levels as degradation products of lipid, protein, and DNA peroxidation in heart. Furthermore, nano-TiO2 exposure attenuated the activities of antioxidative enzymes, such as superoxide dismutase, ascorbate peroxidase, glutathione reductase, glutathione-S-transferase, and levels of antioxidants including ascorbic acid, glutathione, and thiol in heart. Therefore, TiO2 NPs exposure may impair cardiovascular system in mice, and attention should be aroused on the application of nano-TiO2 and their potential long-term exposure effects especially on human beings.

Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver

“…These findings are congruent with other studies that have investigated the potential for a negative cardiovascular impact following pulmonary exposures to various nanomaterials [15,18,22]. One hypothesis proposes that the pulmonary instillation of a nanomaterial establishes a pro-inflammatory condition that primes the target organ for exacerbation of an evoked injury response such as cardiac I/R.…”

Decreased spermatogenesis led to alterations of testis-specific gene expression in male mice following nano-TiO2 exposure

“…The photocatalytic properties of TiO 2 NPs have been proved to raise various issues with respect to its poisonous impacts in the lungs [11][12][13][14], livers [15][16][17][18][19][20][21], kidneys [22][23][24][25], spleens [26][27][28][29], brains [30][31][32][33][34][35][36] and hearts [37,38] of animals.…”

Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO₂; and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO₂ nanoparticles

“…Firstly, the reactive radical oxygen species generated by TiO 2 NPs are more likely to result in oxidative damage to normal tissues, especially the cardiovascular system. 7 Then, UV light cannot penetrate deeply into human tissues, thus limiting its application on superficial tumors. 8 Additionally, UV-mediated reactive oxygen species from TiO 2 NPs have a very short life span, so they would not be able to produce a persistent cancer-killing effect.…”

“…When FA-PEG-TiO 2 NPs loaded with Cur and Sal B are administered via intravenous injection, the reactive radical oxygen species generated by TiO 2 NPs are more likely to result in oxidative damage to the cardiovascular system. 7 In order to cope with this challenge, not only does Sal B protect the cardiovascular system by its stronger antioxidant activity but also it can play an important role in the synergistic antitumor effect with Cur. Therefore, we compounded novel FA-PEG-TiO 2 nanocarriers for codelivery of Cur and Sal B to investigate the synergistic anti-breast carcinoma efficacy.…”

“…The tumor model was established via subcutaneous inoculation of MDA-MB-231 cells into the right armpit of BALB/c-nude mice at a density of 10 7 . In order to effectively access the targeting of FA-NPs and drug accumulation in tumors and organs, DiR was used as a near-IR fluorescence probe, which was encapsulated in the NPs to form DiR-labeled NPs, in the same fashion as loading for Cur and Sal B.…”