2003
DOI: 10.1128/mcb.23.10.3593-3606.2003
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Cardiac p300 Is Involved in Myocyte Growth with Decompensated Heart Failure

Abstract: A variety of stresses on the heart initiate a number of subcellular signaling pathways, which finally reach the nuclei of cardiac myocytes and cause myocyte hypertrophy with heart failure. However, common nuclear pathways that lead to this state are unknown. A zinc finger protein, GATA-4, is one of the transcription factors that mediate changes in gene expression during myocardial-cell hypertrophy. p300 not only acts as a transcriptional coactivator of GATA-4, but also possesses an intrinsic histone acetyltran… Show more

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Cited by 220 publications
(201 citation statements)
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“…In response to hypertrophic stimuli, such as endothelin-1, PE, and isoproterenol, GATA4 is phosphorylated at Ser-105 by the MAPK pathway, which in turn enhances its transcriptional activity and promotes cardiomyocyte hypertrophy (34). In addition, GATA4 is subjected to the lysine modifications via acetylation and sumoylation (10,11). Indeed, the transcriptional co-activator p300 interacts with GATA4 and enhances its transcriptional activity by acetylating lysine residues in the C-terminal region (35,36).…”
Section: Discussionmentioning
confidence: 99%
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“…In response to hypertrophic stimuli, such as endothelin-1, PE, and isoproterenol, GATA4 is phosphorylated at Ser-105 by the MAPK pathway, which in turn enhances its transcriptional activity and promotes cardiomyocyte hypertrophy (34). In addition, GATA4 is subjected to the lysine modifications via acetylation and sumoylation (10,11). Indeed, the transcriptional co-activator p300 interacts with GATA4 and enhances its transcriptional activity by acetylating lysine residues in the C-terminal region (35,36).…”
Section: Discussionmentioning
confidence: 99%
“…PRMT5 Negatively Regulates GATA4 Activity-GATA4 has been shown to regulate expression of various cardiac genes, such as ANF and BNP, and its activity can be potentiated by p300 mediated acetylation (10). Thus, we sought to determine whether PRMT5 affects the transcriptional activity of GATA4.…”
Section: Prmt5mentioning
confidence: 99%
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“…For example, p300 acetylates p53, increases its DNA binding activity, and activates the transcription of p53-inducible genes, contributing to cell cycle arrest or apoptosis (6,7). In cardiac myocytes, p300 acetylates GATA-4, enhances its DNA binding, and plays an important role in the transactivation of hypertrophy-responsive genes (8). However, the roles of HATs and HDACs in post-translational modification of GATA-4 during the differentiation of ES cells into cardiac myocytes remain unknown.…”
mentioning
confidence: 99%