Cardiac Pharmaco–toxicological Studies of Judaicin, Isolated From Artemisia Judaica

Galal, E E; Kandil, Asmaa M.; Abdellatif, Menna M.; Khedr, T; Khafagy, S. M.

doi:10.1055/s-0028-1097918

Cited by 10 publications

(5 citation statements)

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“…Concerning the isolated pure compounds, piperitone and trans-ethyl cinnamate showed pronounced insecticidal and antilarval activity against Spodoptera littoralis [ 22 ]. A sesquiterpene lactone known as judaicin exhibited a cardio-tonic effect slightly better than digoxin [ 23 ]. Another compound that was later identified as cirsimaritin demonstrated antioxidant, anticancer, anti-inflammatory, antimicrobial, antagonistic, antidiabetic, neurological, cardiovascular, and hepatoprotective activities [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

et al. 2021

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Artemisia judaica L. (Family: Asteraceae) exhibited antioxidant, anti-inflammatory, and antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was screened against a panel of cancer cell lines. The results revealed its cytotoxic activity against a lung cancer (A549) cell line with a promising IC50 of 14.2 μg/mL compared to doxorubicin as a standard. This was confirmed through the downregulation of antiapoptotic genes, the upregulation of proapoptotic genes, and the cell cycle arrest at the G2/M phase. Further in vivo study showed that a solid tumor mass was significantly reduced, with a tumor inhibition ratio of 54% relative to doxorubicin therapy in a Xenograft model. From a chemical point of view, various classes of natural products have been identified by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS). The docking study of the detected metabolites approved their cytotoxic activity through their virtual binding affinity towards the cyclin-dependent kinase 2 (CDK-2) and epidermal growth factor receptor (EGFR) active sites. Finally, A. judaica is a fruitful source of polyphenols that are well-known for their antioxidant and cytotoxic activities. As such, the previously reported polyphenols with anti-lung cancer activity were quantified by high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD). Rutin, quercetin, kaempferol, and apigenin were detected at concentrations of 6 mg/gm, 0.4 mg/gm, 0.36 mg/gm, and 3.9 mg/gm of plant dry extract, respectively. It is worth noting that kaempferol and rutin are reported for the first time. Herein, A. judaica L. may serve as an adjuvant therapy or a promising source of leading structures in drug discovery for lung cancer treatment.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

et al. 2021

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“…Artemisia species (Compositae) are known for their antibacterial, anthelmintic, antiinflammatory, stimulatory and antispasmodic activities (1)(2)(3)(4). The interperitoneal administration of santonin, one of the major compounds isolated from these plants (3) was found to cause a sig nificant antipyretic effect in rats (5).…”

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Studies on the Antiinflammatory, Antipyretic and Analgesic Activities of Santonin

Alharbi

Qureshi

Ahmed

et al. 1994

Japanese Journal of Pharmacology

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ABSTRACT-Santonin, a sesquiterpene lactone, commonly found in the plants of the family Compositae was found to show significant antiinflammatory activity on acute inflammatory processes. The activity profile of santonin closely resembled that of a standard non-steroidal antiinflammatory drug, diclofenac sodium. It also showed a significant inhibitory effect on granuloma formation; however, this effect of san tonin was less pronounced as compared to diclofenac sodium. Santonin caused a significant antipyretic effect in mice, which was found to be independent of the route of administration of the drug. It also increas ed the hot plate reaction time of treated mice, similar to morphine.

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“…These bioactivities could be attributed to the plant’s phytochemicals. A. judaica accumulates volatile oil, sesquiterpene lactones, and phenolic compounds ( Galal et al, 1974 ; Abdelgaleil et al, 2008 ; Janaćković et al, 2015 ). Recent phytochemical research by LC/MS/MS showed that A. judaica possessed a plethora of flavonoids, phenolic acids, and terpenoids ( Goda et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-Cryptosporidium parvum activity of Artemisia judaica L. and its fractions: in vitro and in vivo assays

et al. 2023

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BackgroundThis study investigates the toxic activity of Artemisia judaica ethanolic extract (ArEx) as well as its phenolic fraction (ArPh), and terpenoid fraction (ArT) against Cryptosporidium parvum (C. parvum) oocysts.MethodsOver a 4 months period, estimation of the total phenolic (TPC), total flavonoids (TFC), and total terpenoids contents (TTC) in ArEx; investigation of the in vitro antioxidant activity of ArEx, ArPh, and ArT; evaluation of ArEx, ArPh, and ArT toxic activity against C. parvum oocysts using MTT assay; parasitological analysis on ArPh-treated C. parvum oocysts and comet assay were performed both in vitro and in vivo (infectivity).ResultsThe ArEx TPC, TFC, and TTC was 52.6 ± 3.1 mgGAE/g, 64.5 ± 3.1 mg QE/g, and 9.5 ± 1.1 mg Linol/g, respectively. Regarding the phytochemical in vitro antioxidant activity, the ArPh exhibited the highest antioxidant activity compared to the ArEx and ArT. The ArPh showed promising free radical scavenging activity of DPPH and ABTS•+ with IC50 values of 47.27 ± 1.86 μg/mL and 66.89 ± 1.94 μg/mL, respectively. Moreover, the FRAP of ArPh was 2.97 ± 0.65 mMol Fe+2/g while its TAC was 46.23 ± 3.15 mg GAE/g. The ArPh demonstrated toxic activity against C. parvum oocysts with a potent IC50 value of 31.6 μg/mL compared to ArT (promising) and ArEx (non-effective). ArPh parasitological analysis demonstrated MIC90 at 1000 μg/ml and effective oocysts destruction on count and morphology. ArPh fragmented oocysts nuclear DNA in comet assay. Beginning at 200 μg/mL, ArPh-treated oocysts did not infect mice.ConclusionTo combat C. parvum infection, the phenolic fraction of A. judaica L. shows promise as an adjuvant therapy or as a source of potentially useful lead structures for drug discovery.

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Cardiac Pharmaco–toxicological Studies of Judaicin, Isolated From Artemisia Judaica

Cited by 10 publications

References 0 publications

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

Studies on the Antiinflammatory, Antipyretic and Analgesic Activities of Santonin

Anti-Cryptosporidium parvum activity of Artemisia judaica L. and its fractions: in vitro and in vivo assays

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