Cardiac postacute sequelae symptoms of SARS-CoV-2 in community-dwelling adults: cross-sectional study

Ogungbe, Oluwabunmi; Gilotra, Nisha A.; Davidson, Patricia M.; Farley, Jason E.; Himmelfarb, Cheryl Dennison; Post, Wendy S.; Commodore-Mensah, Yvonne

doi:10.1136/openhrt-2022-002084

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…Indeed, in the article reviewed, the new-onset HT was identified using the relative ICD-10 codes. However, our findings are in accordance with those presented by Zhang et al [9] and Ogungbe et al [22], which demonstrated am increased risk for essential HT after COVID-19 infection.…”

Section: Discussionsupporting

confidence: 94%

Risk of Incident New-Onset Arterial Hypertension After COVID-19 Recovery: A Systematic Review and Meta-analysis

Zuin

Rigatelli

Bilato³

et al. 2023

High Blood Press Cardiovasc Prev

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Introduction Arterial Hypertension (HT) has been described as a common comorbidity and independent risk factor of short-term outcome in COVID-19 patients. However, data regarding the risk of new-onset HT during the post-acute phase of COVID-19 are scant. Aim We assess the risk of new-onset HT in COVID-19 survivors within one year from the index infection by a systematic review and meta-analysis of the available data. Methods Data were obtained searching MEDLINE and Scopus for all studies published at any time up to February 11, 2023, and reporting the long-term risk of new-onset HT in COVID-19 survivors. Risk data were pooled using the Mantel–Haenszel random effects models with Hazard ratio (HR) as the effect measure with 95% confidence interval (CI). Heterogeneity among studies was assessed using I 2 statistic. Results Overall, 19,293,346 patients (mean age 54.6 years, 54.6% males) were included in this analysis. Of them, 758,698 survived to COVID-19 infection. Over a mean follow-up of 6.8 months, new-onset HT occurred to 12.7 [95% CI 11.4–13.5] out of 1000 patients survived to COVID-19 infection compared to 8.17 [95% CI 7.34–8.53] out of 1000 control subjects. Pooled analysis revealed that recovered COVID-19 patients presented an increased risk of new-onset HT (HR 1.70, 95% CI 1.46–1.97, p < 0.0001, I 2 = 78.9%) within seven months. This risk was directly influenced by age (p = 0.001), female sex (p = 0.03) and cancer (p < 0.0001) while an indirect association was observed using the follow-up length as moderator (p < 0.0001). Conclusions Our findings suggest that new-onset HT represents an important post-acute COVID-19 sequelae. Supplementary Information The online version contains supplementary material available at 10.1007/s40292-023-00574-5.

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Section: Discussionsupporting

confidence: 94%

Risk of Incident New-Onset Arterial Hypertension After COVID-19 Recovery: A Systematic Review and Meta-analysis

Zuin

Rigatelli

Bilato³

et al. 2023

High Blood Press Cardiovasc Prev

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“…The included studies varied in their definition of “post-COVID-19 condition”: five studies referred to the NICE guidelines [ 47 , 50 , 55 , 57 , 58 ], four based their analyses on the WHO clinical case definition [ 44 , 53 , 56 ], two referred to a temporal definition of the Centers for Disease Control and Prevention (CDC), that cannot be found online any more [ 41 , 43 , 45 ] and eight studies did not use any standardized evidence-based definition to operationalize long-term health effects of COVID-19 [ 42 , 46 , 48 , 49 , 51 , 52 , 54 , 59 ]. Figure 2 shows observation periods of the included studies in relation to the acute COVID-19 infection.…”

Section: Resultsmentioning

confidence: 99%

“…Hirschtick et al also provided two analyses based on two different time measurements, which they labelled as “30+ day COVID-19” for symptoms persisting for 30 or more days and “60+ day COVID-19” for symptoms lasting for 30 or more or 60 or more days after acute SARS-CoV-2 infection [ 46 ]. Five studies measured symptoms earlier than 4 weeks after disease onset [ 41 , 48 , 49 , 51 , 54 ]. Fifteen included studies based their analyses on self-reported long-term health effects of COVID-19.…”

Section: Resultsmentioning

confidence: 99%

Social Inequalities in Long-Term Health Effects After COVID-19—A Scoping Review

Lammers,

Beese,

Hoebel

et al. 2024

Int J Public Health

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Objectives: We aimed to map and synthesize evidence about social inequalities in long-term health effects after COVID-19 (LTHE), often referred to as “long COVID” or “post-COVID-19 conditions.”Methods: We conducted a scoping review of peer-reviewed articles by searching the databases Embase and Scopus. According to predefined inclusion criteria, titles/abstracts and full texts were screened for eligibility. Additionally, reference lists of all included studies were hand-searched for eligible studies. This study followed the PRISMA guidelines for scoping reviews.Results: Nineteen articles were included. LTHE were analysed according to ethnicity, education, income, employment and deprivation indices. The studies varied significantly in their definitions of LTHE. Eighty-two analyses showed no statistically significant associations. At least 12 studies had a high risk of type II errors. Only studies associating deprivation indices and long COVID tended to show a higher prevalence of LTHE in deprived areas.Conclusion: Although some studies indicated social inequalities in LTHE, evidence was generally weak and inconclusive. Further studies with larger sample sizes specifically designed to detect social inequalities regarding LTHE are needed to inform future healthcare planning and public health policies.

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“…Other reported risk factors are poor pre-pandemic mental health, poor general health, and underlying asthma [ 13 ]. With respect to cardiovascular symptoms of PASC, patients with underlying cardiovascular disease (coronary artery disease, hypertension, atrial fibrillation), pre-existing diseases (asthma, diabetes, kidney disease, cancer), and prior hospitalization for COVID-19, have been associated with a higher risk [ 14 ]. The exact pathophysiology with respect to risk factors is yet to be understood fully and requires further research.…”

Section: Reviewmentioning

confidence: 99%

A Review of Long COVID With a Special Focus on Its Cardiovascular Manifestations

Yousif¹,

Premraj²

2022

Cureus

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has been the cause of the century's worst pandemic so far: coronavirus disease 2019 . It has led to unprecedented mortality and morbidity, resulting in devastating consequences worldwide. The acute manifestations of COVID-19 including respiratory as well as multisystem involvement have been causes of great concern among physicians. However, the long-term effects of the coronavirus have left many patients battling with chronic symptoms, ranging from extreme fatigue to cardiomyopathy. In this article, we review the chronic manifestations of COVID-19 with a focus on cardiovascular manifestations. We discuss the pathophysiology, post-acute sequelae, clinical manifestations, approach to the laboratory diagnosis of cardiovascular manifestations of long COVID, and a proposed multidisciplinary treatment method. We also explore the relationship between vaccination and the long COVID syndrome.

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Cardiac postacute sequelae symptoms of SARS-CoV-2 in community-dwelling adults: cross-sectional study

Cited by 18 publications

References 25 publications

Risk of Incident New-Onset Arterial Hypertension After COVID-19 Recovery: A Systematic Review and Meta-analysis

Risk of Incident New-Onset Arterial Hypertension After COVID-19 Recovery: A Systematic Review and Meta-analysis

Social Inequalities in Long-Term Health Effects After COVID-19—A Scoping Review

A Review of Long COVID With a Special Focus on Its Cardiovascular Manifestations

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