Cardiac Potassium Channel hERG Is Regulated by Ubiquitin Ligase Nedd4l

Cell Surface Expression of Human Ether-a-go-go-related Gene (hERG) Channels Is Regulated by Caveolin-3 Protein via the Ubiquitin Ligase Nedd4-2

“…Two previous studies have reported that hERG does not interact with Nedd4-2 (39,40). However, consistent with our previous observations (26) and the present study, a recent study also showed that Nedd4-2 overexpression down-regulates mature hERG channels expressed in HEK 293 cells (27). Thus, the hERG channel could be regulated at the cell surface via a mechanism involving Nedd4-2 alone.…”

“…2D). Indeed, we have reported previously that Nedd4-2 ubiquitinates and eliminates mature hERG channels (26). This observation was subsequently confirmed in a study reported by Albesa et al (27).…”

The Serum- and Glucocorticoid-inducible Kinases SGK1 and SGK3 Regulate hERG Channel Expression via Ubiquitin Ligase Nedd4-2 and GTPase Rab11

“…The PY motif exists in the hERG channel but not in Kv1.5 or EAG (10). Recent works by us and Albesa et al have demonstrated that Nedd4-2 ubiquitinates and subsequently internalizes mature hERG channels from the plasma membrane (10,24,25). SGK is a serine/threonine kinase (26).…”