Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -

Mizuno, Yuji; Harada, Eisaku; Katoh, Daisuke; Kashiwagi, Yusuke; Morikawa, Yoshinobu; Nakagawa, Hitoshi; Yoshimura, Michihiro; Saito, Yoshihiko; Yasue, Hirofumi

doi:10.1507/endocrj.ej12-0239

Cited by 28 publications

(19 citation statements)

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“…This association matches the findings of pioneering work showing that obese individuals in the cohort of the Framingham Heart Study had considerably lower plasma NP levels than those with a normal weight (20). We also previously reported that the secretion of NP from the heart is reduced and that the circulating NP levels are decreased in obese patients compared with non-obese patients (21,22). It is important to discuss the pathophysiological function of adipocytes and their relationship to NP.…”

Section: Discussionsupporting

confidence: 87%

“…Insulin induces the HIF-1α level (31,32) and it is therefore conceivable that BNP production is reduced under conditions of insulin resistance via HIF-1α suppression in obese patients. (21) Adiponectin may play an important role in the link between a low BNP level and insulin resistance. The production of adiponectin is reduced in relation to the severity of obesity (33) and increased by successful therapy for obesity (34).…”

Section: Discussionmentioning

confidence: 99%

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The impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure

et al. 2016

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

The impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure

et al. 2016

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“…In keeping with this hypothesis, cardiac mRNA expression of both ANP and BNP is reduced in obese Zucker fatty rats and db/db mice (50,55). Data in humans are limited; however, a study in subjects who underwent cardiac catheterization has shown that cardiac BNP release is inversely and independently related to BMI (56). Obese individuals may be prone to a relative NP deficiency, stemming from suppressive effects of circulating androgens on ANP and BNP synthesis (57) and possibly from the deleterious systemic and local effects of cardiac ectopic fat on NP synthesis and release (58,59).…”

Section: Nps and Obesity Diabetes And Diabetes Complications Obesitymentioning

confidence: 87%

Natriuretic Peptides, Heart, and Adipose Tissue: New Findings and Future Developments for Diabetes Research

2014

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Natriuretic peptides (NPs) play a key role in cardiovascular homeostasis, counteracting the deleterious effects of volume and pressure overload and activating antibrotic and antihypertrophic pathways in the heart. N-terminal B-type NP (NT-proBNP) also is a promising biomarker of global cardiovascular risk in the general population, and there is increasing interest on its potential use in diabetic patients for screening of silent cardiovascular abnormalities, cardiovascular risk stratification, and guided intervention. Recently, both atrial NP (ANP) and B-type NP (BNP) have emerged as key mediators in the control of metabolic processes including the heart in the network of organs that regulate energy usage and metabolism. Epidemiological studies have shown that ANP and BNP are reduced in people with obesity, insulin resistance, and diabetes, and this deficiency may contribute to enhance their global cardiovascular risk. Moreover, ANP and BNP have receptors in the adipose tissue, enhance lipolysis and energy expenditure, and modulate adipokine release and food intake. Therefore, low ANP and BNP levels may be not only a consequence but also a cause of obesity, and recent prospective studies have shown that low levels of NT-proBNP and midregional proANP (MR-proANP) are a strong predictor of type 2 diabetes onset. Whether ANP and BNP supplementation may result in either cardiovascular or metabolic benefits in humans remains, however, to be established.Natriuretic peptides (NPs) have gained great interest as indicators of the state of cardiovascular health across the spectrum of cardiovascular diseases (CVD) in diabetic subjects (1-4). Recently, NPs also have emerged as key mediators in the control of metabolic processes (5) and have been implicated in the development of diabetes (6,7), shifting current paradigms and opening novel avenues in diabetes research. This review will summarize new findings in the field and discuss their potential clinical relevance. NPS AND THEIR RECEPTORSNPs are a family of genetically distinct and structurally related peptides, including atrial NP (ANP), B-type NP (BNP), and C-type NP (CNP). They share a similar structural conformation, characterized by a peptide ring with a cysteine bridge, which is well preserved throughout evolution, being the portion of the chain that binds to the receptor. ANP and BNP are predominantly secreted by cardiomyocytes, whereas CNP is mainly produced by the central nervous system, the endothelium, the bone, and the reproductive system (8-11).

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“…The production of BNP is decreased in obese patients with heart failure, which was documented in our previous report involving blood sampling from the coronary sinus and aortic root during cardiac catheterization [25]. The molecular mechanisms are still not clear, but some studies have demonstrated roles of peroxisome proliferator-activated receptor (PPAR)-α and HIF-1α in BNP production.…”

Section: Discussionmentioning

confidence: 98%

Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor

et al. 2017

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Background/ObjectivesObesity is believed to be one of the major risk factors for cardiovascular disease in Western countries. However, the effects of obesity should be continuously examined in the Japanese population because the average bodily habitus differs among countries. In this study, we collectively examined the significance of obesity and obesity-triggered risk factors including the low reactivity of B-type natriuretic peptide (BNP), for ischemic heart disease (IHD) in Japanese patients.Methods and resultsThe study patients consisted of 1252 subjects (IHD: n = 970; non-IHD: n = 282). Multiple logistic regression analysis revealed that dyslipidemia, hypertension, diabetes, and the low reactivity of BNP were significant risk factors for IHD, but body mass index (BMI) was not. A theoretical path model was proposed by positioning BMI at the top of the hierarchical model. Exploratory factor analysis revealed that BMI did not play a causative role in IHD (P = NS). BMI was causatively linked to other risk factors (P<0.001 for hypertension; P<0.001 for dyslipidemia; P<0.001 for HbA1c; P<0.001 for LogBNP), and these factors played a causative role in IHD (P<0.001 for hypertension; P<0.001 for dyslipidemia; P<0.001 for HbA1c; P<0.001 for LogBNP). The intrinsic power of the low reactivity of BNP induced by high BMI on the promotion of IHD was fairly potent.ConclusionThis study demonstrated that obesity per se is not a strong risk factor for IHD in Japanese patients. However, several important risk factors triggered by obesity exhibited a causative role for IHD. The low reactivity of BNP is a substantial risk factor for IHD.

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Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -

Cited by 28 publications

References 46 publications

The impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure

The impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure

Natriuretic Peptides, Heart, and Adipose Tissue: New Findings and Future Developments for Diabetes Research

Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor

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