Cardiac remodeling after substantial weight loss: a prospective cardiac magnetic resonance study after bariatric surgery

Jhaveri, Rahul R; Pond, Kyle K.; Hauser, Thomas H.; Kissinger, Kraig V.; Goepfert, Lois; Schneider, Benjamin E.; Jones, Daniel B.; Manning, Warren J.

doi:10.1016/j.soard.2009.01.011

Cited by 59 publications

(47 citation statements)

References 29 publications

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“…24 Interestingly, these changes in HR were accompanied by peripheral muscular metaboreflex responses, which are indicative of enhanced muscle profusion. Studies in adults 30,31 and adolescents 32,33 have shown beneficial adaptations in cardiac structure and function following bariatric surgery, which when coupled with improvements in systemic vascular function, 34,35 may play an important role in regulating HR responses during rest and post-exercise. Although physiologically plausible, this theory is somewhat speculative, and we observed no association between changes in HR response and changes in blood pressure at any time point.…”

Section: Discussionmentioning

confidence: 99%

Changes in Functional Mobility and Musculoskeletal Pain After Bariatric Surgery in Teens With Severe Obesity

et al. 2016

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IMPORTANCE Severe obesity is associated with mobility limitations and higher incidence of multijoint musculoskeletal pain. It is unknown whether substantial weight loss improves these important outcomes in adolescents with severe obesity.OBJECTIVE To examine the association of bariatric surgery with functional mobility and musculoskeletal pain in adolescents with severe obesity up to 2 years after surgery. DESIGN, SETTING, AND PARTICIPANTSThe Teen-Longitudinal Assessment of Bariatric Surgery Study is a prospective, multicenter, observational study, which enrolled 242 adolescents (Յ19 years of age) who were undergoing bariatric surgery from March 2007 through February 2012 at 5 US adolescent bariatric surgery centers. This analysis was conducted in November 2015.INTERVENTIONS Roux-en-Y gastric bypass (n = 161), sleeve gastrectomy (n = 67), or laparoscopic adjustable gastric band (n = 14). MAIN OUTCOMES AND MEASURESParticipants completed a 400-m walk test prior to bariatric surgery (n = 206) and at 6 months (n = 195), 12 months (n = 176), and 24 months (n = 149) after surgery. Time to completion, resting heart rate (HR), immediate posttest HR, and HR difference (resting HR minus posttest HR) were measured and musculoskeletal pain concerns, during and after the test, were documented. Data were adjusted for age, sex, race/ethnicity, baseline body mass index (calculated as weight in kilograms divided by height in meters squared), and surgical center (posttest HR and HR difference were further adjusted for changes in time to completion). RESULTSOf the 206 adolescents with severe obesity included in the study, 156 were female (75.7%), the mean (SD) age was 17.1 (1.6) years, and the mean (SD) body mass index was 51.7 (8.5). Compared with baseline, significant improvements were observed at 6 months for the walk test time to completion (mean, 376 seconds; 95% CI, 365-388 to 347 seconds; 95% CI, 340-358; P < .01), resting HR (mean, 84 beats per minute [bpm]; 95% CI, 82-86 to 74 bpm; 95% CI, 72-76), posttest HR (mean, 128 bpm; 95% CI, 125-131 to 113 bpm; 95% CI, 110-116), and HR difference (mean, 40 bpm; 95% CI, 36-42 to 34 bpm; 95% CI, 31-37). These changes in time to completion, resting HR, and HR difference persisted at 12 months and 24 months. Posttest HR further improved from 6 months to 12 months (mean, 113 bpm; 95% CI, 110-116 to 108 bpm; 95% CI, 105-111). There were statistically significant reductions in musculoskeletal pain concerns at all points.CONCLUSIONS AND RELEVANCE These data provide evidence that bariatric surgery in adolescents with severe obesity is associated with significant improvement in functional mobility and in the reduction of walking-related musculoskeletal pain up to 2 years after surgery.

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Section: Discussionmentioning

confidence: 99%

Changes in Functional Mobility and Musculoskeletal Pain After Bariatric Surgery in Teens With Severe Obesity

et al. 2016

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“…25 However, obesity is an independent risk factor for LV hypertrophy and dysfunction. [26][27][28][29] Left ventricular hypertrophy is related to the increased cardiac output associated with obesity as well as the effect of adipokines (leptin, adiponectin, cardiotrophin 1) on myocyte function. [29][30][31] .…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Patients With the “Malignant Obesity Hypoventilation Syndrome” Admitted to an ICU

Marik

Desai

2012

J Intensive Care Med

112

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“…Obesity is known to be associated with cardiac chamber dilation, with marked increases in wall thickness, a process that leads to eccentric LV hypertrophy [15,16]. With echocardiography, Hsuan et al [17] showed that surgical weight reduction significantly reduces relative wall thickness.…”

Section: Discussionmentioning

confidence: 99%

B-type natriuretic peptide increases after gastric bypass surgery and correlates with weight loss

et al. 2011

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Cardiac remodeling after substantial weight loss: a prospective cardiac magnetic resonance study after bariatric surgery

Cited by 59 publications

References 29 publications

Changes in Functional Mobility and Musculoskeletal Pain After Bariatric Surgery in Teens With Severe Obesity

Changes in Functional Mobility and Musculoskeletal Pain After Bariatric Surgery in Teens With Severe Obesity

Characteristics of Patients With the “Malignant Obesity Hypoventilation Syndrome” Admitted to an ICU

B-type natriuretic peptide increases after gastric bypass surgery and correlates with weight loss

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