2012
DOI: 10.1152/ajpheart.01069.2011
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Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training

Abstract: Calvé A, Haddad R, Barama SN, Meilleur M, Sebag IA, Chalifour LE. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol 302: H2048 -H2057, 2012. First published March 23, 2012; doi:10.1152/ajpheart.01069.2011The impact of cancer therapies on adult cardiac function is becoming a concern as more children survive their initial cancer. Cardiovascular disease is now a significant problem to adult survivors of c… Show more

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Cited by 18 publications
(20 citation statements)
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“…Physical training was observed to promote the attenuation of the decrease in the cardiac index, although this result was not significant. These absolute values differ from those reported by a previous study that also evaluated morphofunctional parameters in trained ovariectomized young rats, showing increases in LV mass and RWT but no change in FS (10). However, considering the normalized values, the majority of cardiac morphological parameters assessed in our study corroborate with the findings of a previous study that did not observe morphological changes in female rats subjected to aerobic exercise training (37).…”
Section: Cardiac Morphological and Functional Parameterscontrasting
confidence: 83%
“…Physical training was observed to promote the attenuation of the decrease in the cardiac index, although this result was not significant. These absolute values differ from those reported by a previous study that also evaluated morphofunctional parameters in trained ovariectomized young rats, showing increases in LV mass and RWT but no change in FS (10). However, considering the normalized values, the majority of cardiac morphological parameters assessed in our study corroborate with the findings of a previous study that did not observe morphological changes in female rats subjected to aerobic exercise training (37).…”
Section: Cardiac Morphological and Functional Parameterscontrasting
confidence: 83%
“…Fifteen publications [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] were included in quality overview, and only 14 [17][18][19][20][21][22][23][24][25][27][28][29][30][31] were included in the quantitative synthesis (meta-analysis); from one study [26] it was not possible to contact the authors or obtaining the FS data from the graphs (Figure 1).…”
Section: Search and Study Selection Processesmentioning
confidence: 99%
“…With regard to the experimental groups in the meta-analysis, 477 animals (50.8%) were allocated into the sedentary group and 462 (49.2%) to the trained group. Of the studies involving rats, six [17,19,23,24,27,28] used females (n=395, 46.4%) and six [20][21][22]25,26,29] used male animals (n=384, 53.6%). Of the studies involving mice, only one [18] used female (n=22, 25%) and two [30,31] used male (n=50, 56.8%) animals.…”
Section: Description Of the Included Studiesmentioning
confidence: 99%
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