Cardiac Rhabdomyoma in a Neonate With Supraventricular Tachycardia

Sadoh, Wilson E.; Obaseki, Darlington Ewaen; Amuabunos, Emmanuel A.; Eregie, Charles Osayande; Isah, Isoken A; Idemudia, Ebenovbe; Vhriterhire, Clement O.

doi:10.1177/2150135113501899

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…Recent reports describe mostly fetuses and newborns with rhabdomyomas and associated SVT with different outcomes. The diagnosis of rhabdomyoma was confirmed either after surgical tumor removal or by autopsy [2,4,9]. Other authors had similar experiences to the one we describe: tumor regressed spontaneously, and the patient had no further episodes of SVT [5].…”

Section: Disscusionsupporting

confidence: 66%

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Echogenic cardiac mass in the left atrium and associated supraventricular tachycardia in a neonate

Pejcic¹,

Mileusnić-Milenović²,

Ratkovic-Jankovic³

2017

Srp Arh Celok Lek

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Introduction Primary cardiac tumors in children are rare and the majority of them are diagnosed before the age of one year. They are mainly rhabdomyomas and have a tendency to regress. The incidence of arrhythmias is not well-defined, depending on the size and location of tumors. Case outline The authors report a female neonate with ongoing fetal supraventricular tachycardia (SVT). Delivery by urgent cesarean section was performed with neither fetal echocardiography nor fetal antiarrhythmic drug intervention. Electrocardiogram confirmed tachycardia with narrow QRS complex at a rate of 260 beats/min. converting to sinus rhythm after a third dose of intravenous bolus injection of adenosine-5'-triphosphate. But the rhythm reverted to SVT showing refractory supraventricular reentrant tachycardia. Echocardiography performed after conversion to sinus rhythm showed an echogenic, well circumscribed mass in the left atrium, fixed to the primum atrial septum without other structural defects. SVT was treated by a bolus of amiodarone followed by an intravenous infusion. Long-term management with oral amiodarone and beta blocker had a good response. During the one-year follow-up echocardiograms were performed every month showing complete regression of cardiac mass, and there has been no recurrence of tachycardia since neonatal period. Conclusion Tumor regression and a good long-term outcome in our patient suggest that it was probably a small but unfavorably positioned rhabdomyoma, associated with fetal and perinatal SVT. Prognosis and outcome of the disease depends on timely diagnosis and prompt and adequate treatment of associated life-threatening arrhythmias.

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Section: Disscusionsupporting

confidence: 66%

“…Others, in the absence of hemodynamic changes, remain undiagnosed and spontaneously regress with time [3]. Histologically, the most common tumor in the neonatal age is rhabdomyoma [4]. If tumors are multiple, associated eventual tuberous sclerosis should be considered [5].…”

Section: Introductionmentioning

confidence: 99%

Echogenic cardiac mass in the left atrium and associated supraventricular tachycardia in a neonate

Pejcic¹,

Mileusnić-Milenović²,

Ratkovic-Jankovic³

2017

Srp Arh Celok Lek

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“…It has been reported that most of the adverse effects caused by mTOR inhibitors did not prevent continued therapy as well as it is a safe and efficacious therapy in patients under 2 years old (Krueger et al, 2018; Saffari et al, 2019). Patients in therapy with everolimus require ongoing evaluation of laboratories including serum electrolytes, complete blood count, blood urea nitrogen, creatinine, urine protein test, glucose, transaminases, and triglyceride levels (Sadoh et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Everolimus for severe arrhythmias in tuberous sclerosis complex related cardiac rhabdomyomas

Sánchez

Alvarado-Socarrás

Castro

et al. 2021

American J of Med Genetics Pt A

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Intracardiac rhabdomyoma is the most common primary cardiac tumor in children. Most cases are associated with tuberous sclerosis complex (TSC). Most of them are asymptomatic in the neonate and do not require treatment. However, some develop cardiovascular symptoms such as arrhythmias, heart failure, and ventricular inflow/outflow tract obstruction in the neonatal period with early death. Many of these tumors are not candidates for surgical resection and medical management is limited. Treatment with mammalian target of rapamycin (mTOR) inhibitor is currently approved for the management of central nervous tumors and angiomyolipoma in TSC. Two patients with malignant arrhythmias related to nonsurgical multiple rhabdomyomas associated with TSC who were successfully treated with an mTOR inhibitor were described. Everolimus therapy showed significant regression of rhabdomyomas with rapid improvement of arrhythmias and heart failure prior to tumor shrinkage.

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“…[6][7][8][9][10][11] A few studies have also reported cases of fatal cardiac arrhythmias in Nigerian subjects. [12,13] However, cases of drug-refractory and life-threatening arrhythmias are probably underreported because of the lack of diagnostic facilities and incompetence at cardiac resuscitation in most centers.…”

Section: Discussionmentioning

confidence: 99%

Review of outcome of radiofrequency cardiac catheter ablations carried out at Madras Medical Mission, India

Uwanuruochi

Saravanan²,

Ganasekar

et al. 2014

Ann Nigerian Med

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A B S T R A C TContext: Radiofrequency ablation (RFA) is a recognised mode of therapy for cardiac arrhythmias. The procedure is carried our regularly at the Cardiac Catheterization Laboratory of Madras Medical Mission, India. Aim: To evaluate the intermediate term follow-up results of radiofrequency catheter ablations. Subjects and Methods: This was a retrospective study carried out in the Cardiac Electrophysiology Department of the Institute of Cardiovascular Diseases, Madras Medical Mission (MMM), India.Records of consecutive cardiac electrophysiologic studies carried out between January and October 2009, together with records of follow-up to March 2014 for those that underwent RFAs were reviewed. In total, the records of 139 cases that had RFAs were analysed. Results: The 139 patients comprised of 65 males and 74 females. The indication for RFA was drug refractory arrhythmias in the vast majority (137 patients). There was a very high success rate (97.1%), following cardiac ablations. Early complications were observed in only 3 (2.2%) patients. Recurrence rate of the indication for RFA was very low (1.43%), and there was no mortality associated with the procedure. Conclusions: The treatment of patients with cardiac arrhythmias using RFA, was associated with a high rate of success, and low rate of complications.

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Cardiac Rhabdomyoma in a Neonate With Supraventricular Tachycardia

Cited by 6 publications

References 9 publications

Echogenic cardiac mass in the left atrium and associated supraventricular tachycardia in a neonate

Echogenic cardiac mass in the left atrium and associated supraventricular tachycardia in a neonate

Everolimus for severe arrhythmias in tuberous sclerosis complex related cardiac rhabdomyomas

Review of outcome of radiofrequency cardiac catheter ablations carried out at Madras Medical Mission, India

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