Cardiac Sarcoidosis Demonstrated by TI-201 and Ga-67 SPECT Imaging

Taki, Junichi; Nakajima, Kénichi; Bunko, Hisashi; Ohguchi, Manabu; Tonami, Norihisa; Hisada, Kinichi

doi:10.1097/00003072-199009000-00010

Cited by 32 publications

(17 citation statements)

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“…This diagnostic method is an important element in assessing the condition of the heart in sarcoidosis [138,[180][181][182][183][184][185][186][187][188][189][190][191][192][193][194][195][196][197][198]. Currently, thallium ( In our study in which we performed single photon emission computed tomography (SPECT), it was found that in cases of sarcoidosis with no apparent ECG abnormalities, the existence of slight radionuclide (RI) abnormalities of the heart muscle were detected.…”

Section: Radionuclide Studiesmentioning

confidence: 99%

Cardiac sarcoidosis: Diagnostic, prognostic, and therapeutic considerations

Sekiguchi

Yazaki

Isobe

et al. 1996

Cardiovasc Drug Ther

151

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Cardiac involvement in patients with sarcoidosis is an important consideration for those who are concerned with this strange disease. Sarcoidosis is not an acute malignant disease but may be noticed at the time of sudden, expected death as fatal myocardial sarcoidosis at autopsy. Even with modern advances in our ability to diagnose heart disease, cardiac sarcoidosis is still often overlooked because of its subclinical disease progression. In view of this, an extensive review of previously published literature and of our own case analyses has been carried out because of the authors' long-term experience with performing Konno's endomyocardial biopsy, which was originally developed in 1962 at the author's institution. However, the sensitivity of endomyocardial biopsy in detecting sarcoid granuloma is low (20-30%), and, instead, various kinds of nongranulomatous pathologies are often seen. During the course of our research it was found that there might exist a racial difference in cardiac sarcoidosis. Cardiac death was much more frequent in Japanese patients. The possibility that heart disease in sarcoidosis is caused by cor pulmonale due to advanced pulmonary fibrosis should be reevaluated because only a limited amount of background data is available. The author's review clarified the fact that cardiac sarcoidosis is caused by myocardial or pericardial involvement, resulting in various kinds of bradyarrhythmias or tachyarrhythmias and/or congestive heart failure. Electrocardiographic (ECG) and Holter monitor readings provide a simple and effective method for early detection of this disease. The incidence of ECG abnormalities in a total of 963 sarcoidosis patients was 22.1%, which was more frequent than that of the sex- and age-matched healthy control subjects (17.9%; p < 0.025). Echocardiography and radionuclide studies also provide useful clinical information. Careful follow-up and early corticosteroid administration followed by small maintenance doses may prevent the progression of the disease and improve prognosis. Owing to the progress in antiarrhythmic drugs and pacemaker implantation, the primary cause of death in cardiac sarcoidosis has changed from sudden death (1976 report) to congestive heart failure (1985 report).

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Section: Radionuclide Studiesmentioning

confidence: 99%

Cardiac sarcoidosis: Diagnostic, prognostic, and therapeutic considerations

Sekiguchi

Yazaki

Isobe

et al. 1996

Cardiovasc Drug Ther

151

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“…However, these modalities are not satisfactorily specifi c for cardiac sarcoidosis. Some investigators have suggested that comparing 201 Tl SPECT scanning with Ga SPECT scanning would increase the specifi city of SPECT scanning for cardiac sarcoidosis [20][21][22]. Other investigators have suggested that dual-SPECT scanning using Ga and 99m Tc-sestamibi represents a very useful diagnostic imaging technique because it improves the diagnostic capability of Ga SPECT and is useful regarding the diagnosis as well as the prediction of the effects of corticosteroids [23].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of 67Ga SPECT and integrated low-dose CT scanning (SPECT/CT) in the diagnosis of cardiac sarcoidosis

et al. 2007

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“…7 An abnormal 67 Ga uptake can localize the cardiac involvement and indicate the likely response to corticosteroid therapy. [8][9][10][11] The present case demonstrates the difficulty in establishing cardiac involvement in the early stage of sarcoidosis. There were not any symptoms of heart failure or ventricular arrhythmia and cardiac involvement was suspected on the basis of trivial ECG changes and LV functional abnormality on echocardiography.…”

Section: Discussionmentioning

confidence: 99%