Cardiac sarcoidosis: Matching speckle tracking echocardiography to macroscopic Ventricular pathology (a case report)

Gesaro, Gabriele Di; Tortorici, Enza; Bellavia, Diego; Licata, Pamela; Chiarello, Gaia; Liotta, Rosa; Scardulla, Cesare; Clemenza, Francesco

doi:10.1016/j.ijcard.2015.11.044

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Segments in hearts from three cardiac transplantation patients was correlated with segmental STE LS; a total of 51 segments from three hearts were assessed, with the higher the degree of deposited amyloid in the cardiac tissue, the worse the segmental longitudinal strain. A single case report comparing an explanted heart in a patient with cardiac sarcoidosis noted a relationship between areas of impaired systolic strain in both ventricles and macro- and microscopic findings of granulomatous disease [35]. Although without histology correlation, in Fabry disease there is similarly a reduction in magnitude of segmental longitudinal strain in areas with disease involvement identified by cardiac MRI [30].…”

Section: Ste Deformation For Tissue Characterisationmentioning

confidence: 99%

Myocardial tissue characterisation using echocardiographic deformation imaging

Moharram

Lamberts

Whalley

et al. 2019

Cardiovasc Ultrasound

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Myocardial pathology results in significant morbidity and mortality, whether due to primary cardiomyopathic processes or secondary to other conditions such as ischemic heart disease. Cardiac imaging techniques characterise the underlying tissue directly, by assessing a signal from the tissue itself, or indirectly, by inferring tissue characteristics from global or regional function. Cardiac magnetic resonance imaging is currently the most investigated imaging modality for tissue characterisation, but, due to its accessibility, advanced echocardiography represents an attractive alternative. Speckle tracking echocardiography (STE) is a reproducible technique used to assess myocardial deformation at both segmental and global levels. Since distinct myocardial pathologies affect deformation differently, information about the underlying tissue can be inferred by STE. In this review, the current available studies correlating STE deformation parameters with underlying tissue characteristics in humans are examined, with separate emphasis on global and segmental analysis. The current knowledge is placed in the context of integrated backscatter and the future of echocardiographic based tissue characterisation is discussed. The use of these imaging techniques to more precisely phenotype myocardial pathology more precisely will allow the design of translational cardiac research studies and, potentially, tailored management strategies.

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Section: Ste Deformation For Tissue Characterisationmentioning

confidence: 99%

Myocardial tissue characterisation using echocardiographic deformation imaging

Moharram

Lamberts

Whalley

et al. 2019

Cardiovasc Ultrasound

View full text Add to dashboard Cite

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Myocardial Involvement in Patients With Histologically Diagnosed Cardiac Sarcoidosis: A Systematic Review and Meta‐Analysis of Gross Pathological Images From Autopsy or Cardiac Transplantation Cases

Okasha

Kazmirczak

Chen

et al. 2019

JAHA

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Background In patients with suspected cardiac sarcoidosis, late gadolinium enhancement on cardiovascular magnetic resonance imaging and/or 18 F‐fluorodeoxyglucose uptake on positron emission tomography are often used to reach a clinical diagnosis of cardiac sarcoidosis. On the basis of data from the imaging literature of clinical cardiac sarcoidosis, no specific features of myocardial involvement are regarded as pathognomonic for cardiac sarcoidosis. Thus, a diagnosis of cardiac sarcoidosis is challenging to make. There has been no systematic analysis of histologically diagnosed cardiac sarcoidosis for patterns of myocardial involvement. We hypothesized that certain patterns of myocardial involvement are more frequent in histologically diagnosed cardiac sarcoidosis. Methods and Results We performed a systematic review and meta‐analysis of gross pathological images from the published literature of patients with histologically diagnosed cardiac sarcoidosis who underwent autopsy or cardiac transplantation. Thirty‐three eligible articles provided images of 49 unique hearts. Analysis of these hearts revealed certain features of myocardial involvement in >90% of cases: left ventricular (LV) subepicardial, LV multifocal, septal, and right ventricular free wall involvement. In contrast, other patterns were seen in 0% to 6% of cases: absence of gross LV myocardial involvement, isolated LV midmyocardial involvement, isolated LV subendocardial involvement, isolated LV transmural involvement, absence of septal involvement, or isolated involvement of only one LV level. Conclusions In this systematic review and meta‐analysis of histologically diagnosed cardiac sarcoidosis, we identified certain features of myocardial involvement that occurred frequently and others that occurred rarely or never. These patterns could aid the interpretation of cardiovascular magnetic resonance imaging and positron emission tomography imaging and improve the diagnosis and the prognostication of patients with suspected cardiac sarcoidosis.

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Cardiac sarcoidosis: Matching speckle tracking echocardiography to macroscopic Ventricular pathology (a case report)

Cited by 2 publications

References 10 publications

Myocardial tissue characterisation using echocardiographic deformation imaging

Myocardial tissue characterisation using echocardiographic deformation imaging

Myocardial Involvement in Patients With Histologically Diagnosed Cardiac Sarcoidosis: A Systematic Review and Meta‐Analysis of Gross Pathological Images From Autopsy or Cardiac Transplantation Cases

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