Cardiac Sources of Cerebral Embolism

Rey, R.; Monteverde, David A.; Sica, R. E. P.

doi:10.1001/archneur.1991.00530160019006

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, some investigations have demonstrated not only autonomic nervous system abnormalities but also peripheral and central nervous system involvement [3]. In the latter case, cerebrovascular disease (CVD) is a recognized cardioembolic complication in patients with Chagas' disease [4] supported by clinical, epidemiological and pathological investigations [5][6][7][8][9][10][11][12]. In Colombia, the prevalence of T. cruzi infection is considered to be 3.3% in the general population [13]; however, studies on neurological complications other than the autonomic one [14] in patients infected by T. cruzi were almost nonexistent until recent times [5][6][7]15].…”

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi-associated cerebrovascular disease: a case-control study in Eastern Colombia

León-Sarmiento

Mendoza

Torres-Hillera

et al. 2004

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi-associated cerebrovascular disease: a case-control study in Eastern Colombia

León-Sarmiento

Mendoza

Torres-Hillera

et al. 2004

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…A clinical study with a cohort of mild cardiac Chagas disease patients reported a stroke frequency of 1.2% during the first year of follow-up [18]. However, chagasic embolic stroke is clinically indistinguishable from other causes of cardioembolic stroke [60]. Common clinical features in patients with brain embolism includes initially decreased level of consciousness, hemiparesis, cortical deficits (such as aphasia, hemineglect, visual field deficits, parietal syndrome), headache and seizures at stroke onset.…”

Section: Findings From Clinical Studies Of Stroke In Chagas Diseasementioning

confidence: 99%

Chagas cardiomyopathy and ischemic stroke

Carod-Artal¹

2006

Expert Review of Cardiovascular Therapy

View full text Add to dashboard Cite

American trypanosomiasis, known as Chagas disease is a major cause of cardiomyopathy in South America. Irreversible damage to the heart can appear 10-20 years after chagasic infection. The relationship between Chagas cardiomyopathy and ischemic stroke has been reviewed. Significant variables that predict ischemic stroke in chagasic patients have been identified: apical aneurysm, cardiac insufficiency, electrocardiogram arrhythmia and female gender. Chagasic cardiomyopathy should be included in the differential diagnosis of the etiology of stroke, being a potential source of cardioembolic stroke.

show abstract

American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke

Carod-Artal

2003

Journal of Neurology, Neurosurgery &Amp; Psychiatry

View full text Add to dashboard Cite

Background: American trypanosomiasis, known as Chagas' disease (CD) is a major cause of cardiomyopathy in South America. Irreversible damage to the heart can appear 10 to 20 years after chagasic infection. The frequency of cerebrovascular complications in chronic CD is unknown. Objectives: To describe a group of patients with chronic or latent CD affected by ischaemic stroke and identify predictive variables for stroke in CD patients. Patients and methods: Retrospective case series of stroke patients with CD was studied using a cross sectional, descriptive design. CD was confirmed by positive immunofluorescence and haemaglutination serology. Data were collected on age, sex, vascular risk factors, previous history of CD, diagnostic stroke subtype, electrocardiograph and echocardiography findings. Frequency of vascular risk factors were compared with a control group of 239 non-chagasic stroke patients. Results: 136 consecutive CD stroke patients, mean age 56 years, 72 women and 64 men were identified. Vascular risk factors were observed in 81.6% of CD patients. Hypertension (70.29% versus 51.47%; p=0.0004), diabetes mellitus (15.9% versus 6.61%; p=0.0143), and tobacco use (53.98% versus 30.88%; p=0.00002) were significantly less frequent in the CD stroke group. Cardiomyopathy was significantly higher in CD stroke patients (45.58% versus 24.69%; p=0.00005). Abnormal electrocardiograms was observed in 82% of chagasic patients (right bundle branch block 39.5%, left anterior fascicular block 35.8%). Left ventricle (LV) diastolic dysfunction (61.47%), LV systolic dysfunction (51.18%), congestive cardiomyopathy (29.92%), and apical aneurysm (15.74%) were the most frequent echocardiographic findings. Aetiologies were cardioembolism (52.2%), undetermined (36.76%), atherothrombotic (8.82%), and small vessel stroke (2.2%). A diagnosis of CD was established after presentation with stroke in 38.23% of the patients. Conclusions: CD should be included in the differential diagnosis of stroke in patients of South American origin.

show abstract

Cardiac Sources of Cerebral Embolism

Cited by 4 publications

References 2 publications

Trypanosoma cruzi-associated cerebrovascular disease: a case-control study in Eastern Colombia

Trypanosoma cruzi-associated cerebrovascular disease: a case-control study in Eastern Colombia

Chagas cardiomyopathy and ischemic stroke

American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke

Contact Info

Product

Resources

About