Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice

Jung, Christian; Wernly, Bernhard; Bjursell, Mikael; Wiseman, John; Admyre, Therése; Wikström, Johannes; Palmer, M Dean; Seeliger, Frank; Lichtenauer, Michael; Franz, Marcus; Frick, Charlotte; Andersson, Ann-Katrin; Elg, Margareta; Pernow, John; Sjöquist, Per-Ove; Bohlooly‐Y, Mohammad

doi:10.1016/j.cardfail.2018.05.004

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…This led the authors to infer that post infarct heart failure is associated with an increased activity of the intracardiac OT system. The results of this study were substantiated by a recent study by Jung et al 20 in which a mice model of cardiac-specific overexpression of OTR exhibited compromised left ventricular function and increased mouse mortality. Although the molecular mechanisms explaining these results were not explored, the main findings of this study provide further evidence of the importance of the cardiac OT system in ischemic conditions.…”

supporting

confidence: 76%

Commentary to an Article: "Molecular Mechanisms Underlying Oxytocin-Induced Cardiomyocyte Protection From Simulated Ischemia-Reperfusion"

Jankowski¹

2018

J Cardiol and Cardiovasc Sciences

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supporting

confidence: 76%

Commentary to an Article: "Molecular Mechanisms Underlying Oxytocin-Induced Cardiomyocyte Protection From Simulated Ischemia-Reperfusion"

Jankowski¹

2018

J Cardiol and Cardiovasc Sciences

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“…It has been shown that 14-week-old transgenic α-MHC-Oxtr mice overexpressing oxytocin receptors manifest significantly greater left ventricle end-diastolic volume, prominent cardiac fibrosis, and enhanced expression of pro-fibrogenic genes. There is also a higher mortality rate among transgenic α-MHC-Oxtr mice than among the wild-type control strain [ 225 ].…”

Section: Cardiovascular Effects Of Vasopressin and Oxytocinmentioning

confidence: 99%

Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation

Szczepañska‐Sadowska

Wsol

Cudnoch-Jędrzejewska

et al. 2021

IJMS

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The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.

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“…It should be noted, however, that excessive stimulation of the cardiac cells by OT may have deleterious consequences, as shown by studies on transgenic mice, in which overexpression of a cardiac-specific OTR gene (driven by the ␣-MHC promoter) resulted in the deterioration of left ventricle function and development of cardiomyopathy with poor survival (92). In pregnant women, intravenous administration of OT during cesarean section resulted in stenocardia, transient profound tachycardia, hypotension, and electrocardiographic signs of myocardial ischemia (180).…”

Section: The Role Of Oxytocin and Vasopressin In Heart Failurementioning

confidence: 99%

The role of oxytocin and vasopressin in the pathophysiology of heart failure in pregnancy and in fetal and neonatal life

Szczepañska‐Sadowska

Cudnoch-Jędrzejewska

Wsol

2020

American Journal of Physiology-Heart and Circulatory Physiology

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Pregnancy and early life create specific psychosomatic challenges for the mother and child, such as changes in hemodynamics, resetting of the water-electrolyte balance, hypoxia, pain, and stress, that all play an important role in the regulation of the release of oxytocin and vasopressin. Both of these hormones regulate the water-electrolyte balance and cardiovascular functions, maturation of the cardiovascular system, and cardiovascular responses to stress. These aspects may be of particular importance in a state of emergency, such as hypertension in the mother or severe heart failure in the child. In this review, we draw attention to a broad spectrum of actions exerted by oxytocin and vasopressin in the pregnant mother and the offspring during early life. To this end, we discuss the following topics: 1) regulation of the secretion of oxytocin and vasopressin and expression of their receptors in the pregnant mother and child, 2) direct and indirect effects of oxytocin and vasopressin on the cardiovascular system in the healthy mother and fetus, and 3) positive and negative consequences of altered secretion of oxytocin and vasopressin in the mother with cardiovascular pathology and in the progeny with heart failure. The present survey provides evidence that moderate stimulation of the oxytocin and vasopressin receptors plays a beneficial role in the healthy pregnant mother and fetus; however, under pathophysiological conditions the inappropriate action of these hormones exerts several negative effects on the cardiovascular system of the mother and progeny and may potentially contribute to the pathophysiology of heart failure in early life.

show abstract

Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice

Cited by 9 publications

References 36 publications

Commentary to an Article: "Molecular Mechanisms Underlying Oxytocin-Induced Cardiomyocyte Protection From Simulated Ischemia-Reperfusion"

Commentary to an Article: "Molecular Mechanisms Underlying Oxytocin-Induced Cardiomyocyte Protection From Simulated Ischemia-Reperfusion"

Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation

The role of oxytocin and vasopressin in the pathophysiology of heart failure in pregnancy and in fetal and neonatal life

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