Cardiac stem cells for myocardial regeneration: promising but not ready for prime time

Lader, Joshua M.; Stachel, Maxine W.; Bu, Lei

doi:10.1016/j.copbio.2017.05.009

Cited by 15 publications

(11 citation statements)

References 65 publications

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“…Whether the EC lineage is analogous to the haematopoietic lineage that gives rise to all blood cells or follows distinct pathways requires further research. {For ongoing research in cardiac stem cells and myocardial regeneration, which is beyond the scope of this review, readers can consider reviewing articles [111, 112]. }…”

Section: Types Of Epcsmentioning

confidence: 99%

Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects

Chopra

Hung

Kwong

et al. 2018

Stem Cells International

161

149

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With the discovery of endothelial progenitor cells (EPCs) in the late 1990s, a paradigm shift in the concept of neoangiogenesis occurred. The identification of circulating EPCs in peripheral blood marked the beginning of a new era with enormous potential in the rapidly transforming regenerative field. Overwhelmed with the revelation, researchers across the globe focused on isolating, defining, and interpreting the role of EPCs in various physiological and pathological conditions. Consequently, controversies emerged regarding the isolation techniques and classification of EPCs. Nevertheless, the potential of using EPCs in tissue engineering as an angiogenic source has been extensively explored. Concomitantly, the impact of EPCs on various diseases, such as diabetes, cancer, and cardiovascular diseases, has been studied. Within the limitations of the current knowledge, this review attempts to delineate the concept of EPCs in a sequential manner from the speculative history to a definitive presence (origin, sources of EPCs, isolation, and identification) and significance of these EPCs. Additionally, this review is aimed at serving as a guide for investigators, identifying potential research gaps, and summarizing our current and future prospects regarding EPCs.

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Section: Types Of Epcsmentioning

confidence: 99%

Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects

Chopra

Hung

Kwong

et al. 2018

Stem Cells International

161

149

View full text Add to dashboard Cite

show abstract

“…Infusion of autologous/allogeneic MSCs in heart failure patients not only prevented ventricular remodeling but also improved the functional capacity, 6-minute walk test, exercise peak VO 2 , Minnesota Living with Heart Failure Questionnaire, and New York Heart Association classification (10). Finally, BMMNCs and CSCs were consistently suggested to curtail LV dysfunction and vascular remodeling while promoting cardiac tissue regeneration (43–45).…”

Section: Stem Cell Therapy For Ischemic Cardiomyopathymentioning

confidence: 99%

Regenerative Therapy for Cardiomyopathies

Wang

Ashraf

et al. 2018

J. of Cardiovasc. Trans. Res.

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Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases. We emphasize the clinical utility of stem cells to improve myocardial structural and function, promote microvascular angiogenesis, and diminish scar size and major adverse cardiovascular events. We also discuss the therapeutic potential of microvesicles, such as exosomes, in the treatment of CVDs, which may open novel avenues for further clinical studies.

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“…Stem cells, defined as immature cells capable of self-renewal and differentiation into a range of mature cell types, play fundamental roles in tissue formation and maintenance, and have broad applications for in vitro disease modeling, drug screening, and in vivo tissue regeneration. (Avior, Sagi, & Benvenisty, 2016; Lader, Stachel, & Bu, 2017; Pelttari, Mumme, Barbero, & Martin, 2017; Rodrigues, Gomes, & Reis, 2011; Rossi & Keirstead, 2009) Neural stem cells (NSCs) in the hippocampus of the adult brain are of particular interest because of their potential to proliferate and differentiate into new neurons and glia throughout adulthood. (Gage, Kempermann, Palmer, Peterson, & Ray, 1998) These tightly regulated NSC processes have impact on learning and memory, as well as implications for the treatment of neurodegenerative disorders such as Alzheimer’s disease.…”

Section: Introductionmentioning

confidence: 99%

High‐throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate

Muckom

McFarland

Yang

et al. 2018

Biotech & Bioengineering

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Advancing our knowledge of how neural stem cell (NSC) behavior in the adult hippocampus is regulated has implications for elucidating basic mechanisms of learning and memory as well as for neurodegenerative disease therapy. To date, numerous biochemical cues from the endogenous hippocampal NSC niche have been identified as modulators of NSC quiescence, proliferation, and differentiation; however, the complex repertoire of signaling factors within stem cell niches raises the question of how cues act in combination with one another to influence NSC physiology. To help overcome experimental bottlenecks in studying this question, we adapted a high-throughput microculture system, with over 500 distinct microenvironments, to conduct a systematic combinatorial screen of key signaling cues and collect high-content phenotype data on endpoint NSC populations. This novel application of the platform consumed only 0.2% of reagent volumes used in conventional 96-well plates, and resulted in the discovery of numerous statistically significant interactions among key endogenous signals. Antagonistic relationships between fibroblast growth factor 2, transforming growth factor β (TGF-β), and Wnt-3a were found to impact NSC proliferation and differentiation, whereas a synergistic relationship between Wnt-3a and Ephrin-B2 on neuronal differentiation and maturation was found. Furthermore, TGF-β and bone morphogenetic protein 4 combined with Wnt-3a and Ephrin-B2 resulted in a coordinated effect on neuronal differentiation and maturation. Overall, this study offers candidates for further elucidation of significant mechanisms guiding NSC fate choice and contributes strategies for enhancing control over stem cell-based therapies for neurodegenerative diseases.

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Cardiac stem cells for myocardial regeneration: promising but not ready for prime time

Cited by 15 publications

References 65 publications

Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects

Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects

Regenerative Therapy for Cardiomyopathies

High‐throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate

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