Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults

Lin, Jin-Ching; Sung, Kuo‐Tzu; Su, Cheng‐Huang; Chou, Tzu-Hsun; Lo, Chi‐In; Tsai, Jui‐Peng; Chang, Shun-Chuan; Lai, Yau‐Huei; Hu, Kuang-Chun; Liu, Chia‐Yuan; Yun, Chun‐Ho; Hung, Chung‐Lieh; Yeh, Hung‐I; Lam, Carolyn S.P.

doi:10.1161/circimaging.117.007047

Cited by 30 publications

(36 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent meta‐analysis of 47 cohort studies, including 12 million individuals, found that the relative risks for heart failure associated with type 2 diabetes were 1.95 (95% CI 1.70–2.22) in women and 1.74 (95% CI 1.55–1.95) in men, with a pooled men‐to‐women ratio of the relative risks of 1.09 (95% CI 1.05–1.13), indicating a significant difference 59 . Women with type 2 diabetes show more pronounced adverse left ventricular remodelling (oriented toward concentric hypertrophy), and have a lower quality of life and worse outcomes compared with type 2 diabetic men, even when they have a normal body mass index (BMI) and glucose levels in the ‘pre‐diabetes’ range 60,61 …”

Section: Occurrence Of Heart Failurementioning

confidence: 99%

Epidemiology of heart failure

Groenewegen

Rutten

Mosterd

et al. 2020

European J of Heart Fail

1,319

937

View full text Add to dashboard Cite

The heart failure syndrome has first been described as an emerging epidemic about 25 years ago. Today, because of a growing and ageing population, the total number of heart failure patients still continues to rise. However, the case mix of heart failure seems to be evolving. Incidence has stabilized and may even be decreasing in some populations, but alarming opposite trends have been observed in the relatively young, possibly related to an increase in obesity. In addition, a clear transition towards heart failure with a preserved ejection fraction has occurred. Although this transition is partially artificial, due to improved recognition of heart failure as a disorder affecting the entire left ventricular ejection fraction spectrum, links can be made with the growing burden of obesity-related diseases and with the ageing of the population. Similarly, evidence suggests that the number of patients with heart failure may be on the rise in low-income countries struggling under the double burden of communicable diseases and conditions associated with a Western-type lifestyle. These findings, together with the observation that the mortality rate of heart failure is declining less rapidly than previously, indicate we have not reached the end of the epidemic yet. In this review, the evolving epidemiology of heart failure is put into perspective, to discern major trends and project future directions.

show abstract

Section: Occurrence Of Heart Failurementioning

confidence: 99%

Epidemiology of heart failure

Groenewegen

Rutten

Mosterd

et al. 2020

European J of Heart Fail

1,319

937

View full text Add to dashboard Cite

show abstract

“…Diabetes is pandemic and is a growing healthcare burden worldwide [1,2]. Recently, lean diabetes (people with diabetes and a low BMI [<25 kg/m 2 ]) has been highlighted as an emerging pathological condition [3,4] and has been reported to have a higher mortality than excessive weight or even grade I obese diabetes [4][5][6][7]. However, people with low BMI (lean/normal weight, particularly BMI <22-23 kg/m 2 ) also had higher mortality than overweight people in the general population [8,9].…”

Section: Introductionmentioning

confidence: 99%

Complex interaction of fasting glucose, body mass index, age and sex on all-cause mortality: a cohort study in 15 million Korean adults

Jung

et al. 2020

Diabetologia

View full text Add to dashboard Cite

Aims/hypothesis The aim of this work was to examine whether synergistic associations with mortality exist for BMI and fasting blood glucose (FBG) and to identify FBG-BMI combined subgroups with higher mortality according to sex and age. Methods A total of 15,149,275 Korean adults participated in health examinations during 2003-2006 and were followed up until December 2018. Mortality HRs of 40 FBG-BMI combined groups were assessed by Cox proportional hazards models. Results During a mean 13.7 years of follow-up, 1,213,401 individuals died. A J-shaped association was seen between FBG and all-cause mortality for all BMI categories. Those with BMI <20 kg/m 2 had the highest mortality for any given FBG level, followed by those with BMI 20-22.4 kg/m 2. The detrimental effect of elevated FBG was greater among leaner individuals than more corpulent individuals. Moreover, the synergistic adverse effects of hyperglycaemia and leanness was stronger in younger adults than in older adults. Compared with the reference group (overweight with normoglycaemia), age-and sex-adjusted HRs of the leanest with normoglycaemia (BMI <20 kg/m 2 and FBG 4.4-5.2 mmol/l), overweight with diabetes (BMI 25-27.4 kg/m 2 and FBG ≥10.0 mmol/l) and leanest with diabetes (BMI <20 kg/m 2 and FBG ≥10.0 mmol/l) were 1.29, 2.59 and 11.18, respectively, in those aged 18-44 years and 1.56, 1.72 and 2.87, respectively, in those aged 75-99 years. The identification of BMI-FBG subgroups associated with higher mortality was not straightforward, illustrated by the group with FBG 6.1-6.9 mmol/l and BMI 20-22.4 kg/m 2 having a similar or higher mortality compared with the group with FBG 7.0-9.9 mmol/l and BMI ≥22.5 kg/m 2. In women aged <45 years with FBG <6.9 mmol/l, those with BMI ≥27.5 kg/m 2 had the highest mortality, whereas individuals with BMI <20 kg/m 2 had the highest mortality for each given FBG level in other age and sex groups. Conclusions/interpretation Leanness and hyperglycaemia interact together to increase mortality in a supra-multiplicative manner, especially in younger adults; the interactions of BMI, FBG, sex and age with mortality are complex.

show abstract

“…The combination of elevated plasma glucose but with a maintained plasma insulin level in these HFD/STZ rats is consistent with insulin resistance ( Reed et al, 2000 ; Sharma et al, 2011 ; Guo et al, 2012 ). However, the lower body weight and fat mass at study endpoint compared to controls is not entirely reflective of obese T2DM ( Lin et al, 2018 ; Bai et al, 2019 ), but rather as a model of T2DM, an emerging clinical feature in many diabetic populations ( Balasubramanyam et al, 2011 ; Florez and Castillo-Florez, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Velagic

Qin

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Conclusion:Both NO• and HNO contribute to endothelium-dependent relaxation in carotid arteries. In diabetes, NO•-mediated relaxation is impaired, whereas HNO-mediated relaxation was preserved. The potential for preserved HNO activity under pathological conditions that are associated with oxidative stress indicates that HNO donors may represent a viable therapeutic approach to the treatment of vascular dysfunction.

show abstract

Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults

Abstract: These data demonstrate the presence of preclinical cardiac remodeling and systolic dysfunction in prediabetic and diabetic Chinese adults, occurring at lower thresholds of glycemic indices than defined by international standards, particularly in lean individuals.

Cited by 30 publications

References 48 publications

Epidemiology of heart failure

Epidemiology of heart failure

Complex interaction of fasting glucose, body mass index, age and sex on all-cause mortality: a cohort study in 15 million Korean adults

Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Contact Info

Product

Resources

About