Cardiac structure and function and quality of life associations in HFpEF: An analysis from TOPCAT-Americas

A retrospective study on the clinical significance of cardiac computed tomography in heart failure patients with preserved ejection fraction

“…Further univariate Cox regression analysis revealed that the LVEDVI, LVESVI, LAEDVI, LAESVI, LVM, LVTEF, and LATEF were factors associated with clinical outcomes in HFpEF patients, while multivariate Cox regression analysis identified the E/e’, LAEDVI, LVM, LVTEF, and LATEF as influencing factors. A previous study by Ferreira et al ( 9 ) showed that health-related quality of life was negatively correlated with LVEDD; combined with these previous results, we suggest that elevated LVEDVI and LVESVI are related to poor prognosis and quality of life in HFpEF patients. Additionally, we observed that several blood parameters showed a downward trend in the event group.…”

“…CT can not only observe the cardiac structure but also accurately report on the vascular condition. A previous study has pointed out that cardiac structure and function are somewhat correlated with quality of life in HFpEF patients ( 9 ). However, there is no evidence-based medical research on the correlation between cardiac function indicators detected by CT and the clinical outcomes of HFpEF patients.…”