Cardiac sympathetic denervation and anxiety in Parkinson disease

Carli, G.; Kanel, P.; Michalakis, F.; Roytman, S.; Bohnen, J.L.B.; Wigstrom, T.P.; Scott, P.; Albin, R.L.; Wong, K.K.; Raffel, D.; Bohnen, N.I.

doi:10.1016/j.parkreldis.2024.106997

Cited by 3 publications

References 12 publications

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The Effect of Dysautonomia on Motor, Behavioral, and Cognitive Fluctuations in Parkinson's Disease

Mahajan,

Morrow,

Seemiller

et al. 2024

Movement Disorders

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BackgroundMotor and nonmotor fluctuations adversely impact the quality of life in Parkinson's disease (PD). Dysautonomia, a feature frequently associated with PD and a possible adverse effect of dopaminergic therapy, may be comorbid with fluctuations.ObjectiveWe sought to evaluate the effect of dysautonomia on motor and nonmotor fluctuations in PD.MethodsTwo hundred subjects with PD were evaluated in both on and off dopamine states to assess changes in symptoms related to dopaminergic fluctuations. Multivariable logistic regression was performed to assess the association of dysautonomia with motor, cognitive, and psychiatric worsening from on to off states with adjustment for disease duration, levodopa equivalent daily dosage (LEDD), and dopamine‐agonist LEDD.ResultsSubjects with dysautonomia had greater odds of clinically meaningful change in motor features (odds ratio [OR]: 3.0), cognition (OR: 3.4), and anxiety (OR: 4.3) compared to those without dysautonomia.ConclusionsDysautonomia may be a contributory mechanism behind fluctuations in PD. The exact nature of this relationship deserves further evaluation. © 2024 International Parkinson and Movement Disorder Society.

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The Effect of Dysautonomia on Motor, Behavioral, and Cognitive Fluctuations in Parkinson's Disease

Mahajan,

Morrow,

Seemiller

et al. 2024

Movement Disorders

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Behavioral disorders in Parkinson disease: current view

Jellinger

2024

J Neural Transm

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The effect of dysautonomia on motor, behavioral and cognitive fluctuations in Parkinson’s disease

Mahajan,

Morrow,

Seemiller

et al. 2024

Preprint

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BackgroundMotor and non-motor fluctuations adversely impact quality of life in Parkinson’s disease (PD). Dysautonomia, a feature frequently associated with PD and a possible adverse effect of dopaminergic therapy, may be comorbid with fluctuations.ObjectivesWe sought to evaluate the effect of dysautonomia on motor and non-motor fluctuations in PDMethodsTwo hundred subjects with PD were evaluated in both “on” and “off” dopamine states to assess changes in symptoms related to dopaminergic fluctuations. Multivariable logistic regression was performed to assess the association of dysautonomia with motor, cognitive, and psychiatric worsening from ON to OFF states with adjustment for disease duration, levodopa equivalent daily dosage (LEDD), and dopamine agonist LEDD.ResultsSubjects with dysautonomia had greater odds of clinically meaningful change in motor features (OR 3.0), cognition (OR 3.4) and anxiety (OR 4.3) compared to those without dysautonomia.ConclusionsDysautonomia may be a contributory mechanism behind fluctuations in PD. The exact nature of this relationship deserves further evaluation.

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Cardiac sympathetic denervation and anxiety in Parkinson disease

Cited by 3 publications

References 12 publications

The Effect of Dysautonomia on Motor, Behavioral, and Cognitive Fluctuations in Parkinson's Disease

The Effect of Dysautonomia on Motor, Behavioral, and Cognitive Fluctuations in Parkinson's Disease

Behavioral disorders in Parkinson disease: current view

The effect of dysautonomia on motor, behavioral and cognitive fluctuations in Parkinson’s disease

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