Cardiac sympathetic hyperactivity in chronic kidney disease — a comparison between haemodialysis and peritoneal dialysis patients

Chrapko, Beata; Grzebalska, Agnieszka; Książek, Andrzej; Drop, Andrzej

doi:10.5603/nmr.2014.0021

Cited by 5 publications

(5 citation statements)

References 49 publications

(74 reference statements)

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“…These results concur with reports of SNS activity in subjects with hypertension [33], obesity [34] and diabetes [35]. In this regard, SNS hyperactivity has been described in patients with CKD [36,37] and it supports why CKD is considered a risk factor for CVD development [38].…”

Section: Sns Hyperactivity Has Important Effects On Several Diseasessupporting

confidence: 90%

“…Finally, we found that renalase and alpha amylase have influence on T2DM and ESRD groups, additionally, a positive correlation between alpha amylase, plasma concentrations of catecholamines and diabetes evolution were found. These results suggests that determination of salivary alpha amylaseas a marker of non-invasive sympathetic activity in T2DM and ESRD patients, results of clinical importance [36,37].…”

Section: Sns Hyperactivity Has Important Effects On Several Diseasesmentioning

confidence: 79%

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Sympathetic Nervous System Activity in Patients with Metabolic Syndrome, Type 2 Diabetes Mellitus and Chronic Kidney Disease. Role of Renalase and Alpha Amylase

LE¹,

Gp²,

Ca³

et al. 2021

jdismarkers

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Aim: To evaluate serum renalase and salivary alpha amylase concentrations and their relationship with plasma catecholamine levels in patients with Metabolic Syndrome (MS), Type 2 Diabetes Mellitus (T2DM), and End-Stage Renal Disease (ESRD). Method: In cross-sectional study 163 patients were enrolled; 43 patients with MS, 93 withT2DM, 13 with ESRD, and 14 healthy subjects (control group). All patients had their ascription to the UMAA/UMF No. 75, in Morelia, Michoacan, Mexico. Glucose, creatinine, cholesterol, triglycerides, HDL, and renalase were measurement in serum, and Dopamine (DA), Epinephrine (E) and Norepinephrine (NE) in plasma. An aliquot of saliva was collected for alpha amylase determination. Results: High plasma concentrations of DA, E and NE (p<0.0001) was founded in T2DM and ESRD patients. Renalase was lower in ESRD compared to MS and T2DM patients (p<0.0001). High concentrations of alpha amylase were found in MS, T2DM, and ESRD patients in comparison with control group (p<0.0001). Catecholamines correlated positively with alpha amylase and diabetes evolution. Conclusion: Sympathetic hyperactivity in MS, T2DM and ESRD patients was founded. Renalase could be proposed as biomarker of renal function and salivary alpha amylase as sympathetic hyperactivity. Additional studies are required to evaluate the pathophysiological mechanisms involved of SNS in CKD development.

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Section: Sns Hyperactivity Has Important Effects On Several Diseasessupporting

confidence: 90%

Section: Sns Hyperactivity Has Important Effects On Several Diseasesmentioning

confidence: 79%

Sympathetic Nervous System Activity in Patients with Metabolic Syndrome, Type 2 Diabetes Mellitus and Chronic Kidney Disease. Role of Renalase and Alpha Amylase

LE¹,

Gp²,

Ca³

et al. 2021

jdismarkers

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“…Two studies examining cardiac and skin SNS response showed no differences between the two dialysis modalities. 39,40 Short-term blood pressure variability (BPV), a parameter closely related with ANS function and sympathetic versus parasympathetic drive, 41,42 was also not different between HD and PD patients in a recent study. 34…”

Section: Discussionmentioning

confidence: 90%

“…Two studies examining cardiac and skin SNS response showed no differences between the two dialysis modalities. 39,40 Shortterm blood pressure variability (BPV), a parameter closely related with ANS function and sympathetic versus parasympathetic drive, 41,42 was also not different between HD and PD patients in a recent study. 34 An exception to our aforementioned findings is the different response in some HRV indices during the recovery period following the sit-to stand test between the HD and PD groups.…”

Section: Discussionmentioning

confidence: 92%

Heart rate variability at rest and in response to stress: Comparative study between hemodialysis and peritoneal dialysis patients

Faitatzidou,

Dipla,

Theodorakopoulou

et al. 2023

Exp Biol Med (Maywood)

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Cardiac arrhythmias and sudden death are the leading causes of mortality in end-stage kidney disease (ESKD). Autonomic nervous system (ANS) dysfunction contributes to this arrhythmogenic background. This study compared heart rate variability (HRV) indices between hemodialysis (HD) and peritoneal dialysis (PD) patients, both at rest and in response to mental and physical stimulation maneuvers. Thirty-four HD and 34 PD patients matched for age, sex, and dialysis vintage, and 17 age- and sex-matched controls were studied. ANS function was examined by linear and non-linear HRV indices. Heart rate was recorded continuously (Finometer-PRO) at rest and during ANS maneuvers (orthostatic, mental-arithmetic, sit-to-stand, handgrip exercise tests). At rest, no significant differences between HD and PD were observed in HRV (root mean square of successive differences [RMSSD]: HD = 57.1 ± 81.1 vs PD = 69.6 ± 113.4 ms; P = 0.792), except for detrended fluctuation analysis (DFA-α1) (HD = 0.87 ± 0.40 vs PD = 0.70 ± 0.20; P = 0.047). DFA-α1 was significantly lower in PD than controls (1.00 ± 0.33; P < 0.05). All HRV indices during the mental-arithmetic test (RMSSD: HD = 128.2 ± 346.0 vs PD = 87.5 ± 150.0 ms; P = 0.893) and the physical stress tests were similar between HD and PD. The standard deviation along the line-of-identity (SD2)/the standard deviation perpendicular to the line-of-identity (SD1) ratio during mental-arithmetic was marginally lower in HD and significantly lower in PD than controls (PD = 1.31 ± 0.47 vs controls = 1.79 ± 0.64; P < 0.05). Both dialysis groups presented similar patterns in HRV responses during orthostatic and handgrip exercise tests. After the sit-to-stand, RMSSD, SD1, SD2, and DFA-α2 were higher compared to rest only in HD (RMSSD = 57.1 ± 81.1 vs 126.7 ± 185.7 ms; P = 0.028), suggesting a greater difficulty of HD patients in recovering normal ANS function in response to physical stress. In conclusion, HRV indices at rest and after mental and physical stimulation did not differ between HD and PD; however, the ANS responses following the sit-to-stand test were more impaired in HD. These findings suggest that ANS dysfunction is not largely affected by dialysis modality, but small differences in normal ANS recovery may exist.

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“…Both PD and HD patients exhibited diminished HR responses after the above cardiac ANS tests compared to controls, but no differences between the two dialysis groups were displayed [90]. Another study in 14 PD and 20 HD patients measured functional indices of global cardiac SNS activity (eHMR, dHMR, WR) through 123 I-mIBG myocardial scintigraphy and showed that functional cardiac SNS indices were similar between the two groups [91]. In a study applying nerve conduction methods and SSR in 24 PD and 20 HD patients, sensory and motor nerve conduction velocities and SSR parameters (latency, amplitude) were examined.…”

Section: Studies Evaluating Ans Dysfunction In Pd Patientsmentioning

confidence: 99%

Autonomic Nervous System Dysfunction in Peritoneal Dialysis Patients: An Underrecognized Cardiovascular Risk Factor?

Faitatzidou,

Karagiannidis,

Theodorakopoulou

et al. 2023

Am J Nephrol

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Background: In patients with end-stage kidney disease (ESKD) receiving peritoneal dialysis (PD) cardiovascular events represent the predominant cause of morbidity and mortality, with cardiac arrhythmias and sudden death being the leading causes of death in this population. Autonomic nervous system (ANS) dysfunction is listed among the non-traditional risk factors accounting for the observed high cardiovascular burden, with a plethora of complex and not yet fully understood pathophysiologic mechanisms being involved. Summary: In recent years, preliminary studies have investigated and confirmed the presence of ANS dysfunction in PD patients, while relevant results from cohort studies have linked ANS dysfunction with adverse clinical outcomes in these patients. In light of these findings, ANS dysfunction has been recently receiving wider consideration as an independent cardiovascular risk factor in PD patients. The aim of this review is to describe the mechanisms involved in the pathogenesis of ANS dysfunction in ESKD and particularly PD patients and to summarize the existing studies evaluating ANS dysfunction in PD patients. Key messages: ANS dysfunction in PD patients is related to multiple complex mechanisms that impair the balance between SNS/PNS and this disruption represents a crucial intermediator of cardiovascular morbidity and mortality in this population.

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Cardiac sympathetic hyperactivity in chronic kidney disease — a comparison between haemodialysis and peritoneal dialysis patients

Abstract: These results suggest that the applied method of renal replacement therapy has no significant influence on global activity of cardiac sympathetic nervous system.

Cited by 5 publications

References 49 publications

Sympathetic Nervous System Activity in Patients with Metabolic Syndrome, Type 2 Diabetes Mellitus and Chronic Kidney Disease. Role of Renalase and Alpha Amylase

Sympathetic Nervous System Activity in Patients with Metabolic Syndrome, Type 2 Diabetes Mellitus and Chronic Kidney Disease. Role of Renalase and Alpha Amylase

Heart rate variability at rest and in response to stress: Comparative study between hemodialysis and peritoneal dialysis patients

Autonomic Nervous System Dysfunction in Peritoneal Dialysis Patients: An Underrecognized Cardiovascular Risk Factor?

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