Cardiac sympathetic imaging in the diagnosis of cardiac autonomic neuropathy in pre-diabetes

Waqar, Fahad; Gerson, Myron C.

doi:10.1007/s12350-015-0082-y

Cited by 3 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of the most dangerous and frequent complications is autonomic neuropathy. One facet of diabetic autonomic neuropathy is the cardiac autonomic neuropathy, as a result of profuse subclinical inflammatory processes that are also present in hyperglycemia [28]. Heart rate variability is a measure of sympathovagal imbalance, and it has been long used for the evaluation of the function of autonomic nervous system, either for research purposes or in the clinical setting [29].…”

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Stefanaki

Michos

Latsios

et al. 2020

IJERPH

View full text Add to dashboard Cite

Prediabetes in the form of impaired fasting glucose, impaired glucose tolerance, or both is considered as a preliminary stage for the onset of diabetes and diabetic complications. Hormonal fluctuations in adolescence are accompanied by body composition modifications, which are associated with insulin resistance and subclinical inflammation. Bioimpedance (BIA) accurately evaluates body composition, and heart rate variability (HRV) assesses cardiac autonomic function, which are frequently afflicted by insulin resistance. We aimed at evaluating the effect of glycemic status on mental stress, anxiety, and depression status in adolescents with impaired fasting glucose, body composition, and HRV parameters. This is a case-control study to evaluate the effect of the hyperglycemia on depression, anxiety, and stress levels (DASS21 questionnaire), body composition (BIA-ACC—BIOTEKNA©), and HRV (PPG Stress Flow—BIOTEKNA©), between euglycemic adolescents (euglycemic group) and adolescents with impaired fasting glucose (prediabetic group), aged 12–20 years. No differences were found between the prediabetic (n = 13) and the euglycemic (n = 16) groups in the outcome measures, possibly due to the number of participants. Interestingly, females, irrespective of their glycemic status, exhibited altered sympathovagal function as revealed by impaired HRV. In the euglycemic group, HRV parameters were significantly correlated and in line with the DASS21 scores, but in the prediabetic group, similarities to those of adults were observed. Impaired fasting glucose had no impact on mental health, body composition, or HRV parameters in adolescents. HRV parameters were impaired in females, irrespective of their glycemic status. This finding implies that females seem to be more prone to stress disorders, even from a young age. Future studies are needed to confirm these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Stefanaki

Michos

Latsios

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Diabetes has been shown to be associated with reduced cardiac MIBG uptake in a small proportion of patients with clinical autonomic neuropathy [23] but similar to healthy controls in another study of patients with impaired glucose tolerance [24]. In our clinical studies in Lewy body disease we aim to assess cardiac MIBG in a "real-world" setting, where diabetes and risk factors for cardiac disease are extremely common.…”

Section: Phantom Calibrationmentioning

confidence: 99%

Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age

Roberts

Lloyd

Kane

et al. 2021

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

Purpose Cardiac I 123-MIBG image interpretation is affected by population differences and technical factors. We recruited older adults without cognitive decline and compared their cardiac MIBG uptake with results from the literature. Methods Phantom calibration confirmed that cardiac uptake results from Japan could be applied to our centre. We recruited 31 controls, 17 individuals with dementia with Lewy bodies (DLB) and 15 with Alzheimer's disease (AD). Images were acquired 20 minutes and four hours after injection using Siemens cameras with medium energy low penetration (MELP) collimators. Local normal heart-tomediastinum (HMR) ratios were compared to Japanese results. Results Siemens gamma cameras with MELP collimators should give HMRs very close to the calibrated values used in Japan. However, our cutoffs with controls were lower at 2.07 for early and 1.86 for delayed images. Applying our lower cutoff to the dementia patients may increase the specificity of cardiac MIBG imaging for DLB diagnosis in a UK population without reducing sensitivity. Conclusions Our local HMR cutoff values are lower than in Japan, higher than in a large US study but similar to those found in another UK centre. UK centres using other cameras and collimators may need to use different cutoffs to apply our results.

show abstract

“…Щипергликемийа дюврц дедикдя глцкозанын сявиййясинин 10 ммол/л-дян чох олмасы баша дцшцлцр. Щипогликемийа дюврцндя ися глцкозанын сявиййясинин 3,9 ммол/л-дян аз олмасы баша дцшцлцр [4].…”

Section: ыыunclassified

II tip şəkərli diabet xəstələrində kardial avtonom neyropatiya diaqnostikasında innovasiya

2018

View full text Add to dashboard Cite

Diabetik neyropatiya çoxaspektli problemdir və zamanında aşkarlanması və ağırlaşmalarının müalicəsi üçün endokrinoloqların müştərək müşahidəsini tələb edir. Diabetik vegetativ kardial neyropatiya – şəkərli diabet zamanı sinir lifinin zədələnməsinin əlamətlərindən biridir. Kardial neyropatiya hiperqlikemiya zamanı ürəyin zədələnməsinin variantlarından biridir. Təqdim edilmiş məqalədə kardial avtonom neyropatiyanın diaqostikasına yeni baxış haqda məlumat verilir.

show abstract

Cardiac sympathetic imaging in the diagnosis of cardiac autonomic neuropathy in pre-diabetes

Cited by 3 publications

References 24 publications

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age

II tip şəkərli diabet xəstələrində kardial avtonom neyropatiya diaqnostikasında innovasiya

Contact Info

Product

Resources

About