Cardiac telerehabilitation with long-term follow-up reduces GlycA and improves lipoprotein particle profile: A randomised controlled trial

Dalli-Peydró, Ernesto; Gisbert-Criado, Rafael; Amigó, Núria; Sanz-Sevilla, Nuria; Cosı́n-Sales, Juan

doi:10.1016/j.ijcard.2022.08.017

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Similar to previous findings, such as in the randomized controlled trial of Pfaeffli et al [ 55 ], patients with CAD in the experimental group received 6 months of personalized telehealth intervention with online support and found that the LDL-C levels of the experimental group were lower than those in the control group. In the trial of Dalli-Peydró et al [ 56 ], who used a smartphone app to instruct participants through exercise schedules and communicate with patients via text message, the results showed that prevented deterioration of the TG/HDL ratio. And one study [ 57 ] has shown that if patients with acute myocardial infarction who received PCI and standard medical therapy after 1 year follow-up of LDL-C still ≥ 1.8 mmol/L, more than 65% of patients had an increased risk of long-term death by 42% ~ 45%.…”

Section: Discussionmentioning

confidence: 99%

Effects of home-based cardiac telerehabilitation programs in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Zhang

et al. 2023

BMC Cardiovasc Disord

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Background Recent advances in telecommunications technology have raised the possibility of telehealth intervention delivering cardiac telerehabilitation, which may provide the efficacy of health services in patients after percutaneous coronary intervention (PCI). This study aimed to investigate the effects of home-based cardiac telerehabilitation (HBCTR) in patients undergoing PCI. Methods We performed a comprehensive search of the following electronic databases: PubMed, Cochrane Central, Web of Science, Embase, CNKI, and WANFANG. For the prespecified outcomes, the primary outcomes were results of physical function (the six-minute walking test, 6MWT) and quality of life (QoL) of the participants. The secondary outcomes were results of (1) blood pressure; (2) full lipid profile (3) reliable assessment of anxiety and depression in patients. Results All studies were conducted between 2013 and 2022, and a total of 5 articles could be included in the quantitative meta-analysis. The results showed that there was a statistically significant difference between the HBCTR intervention group and the control group in 6WMT (MD 16.59, 95%CI 7.13 to 26.06, P = 0.0006), but there was no difference in QoL (SMD − 0.25, 95%CI − 1.63 to 1.13, P = 0.73). According to the fixed effects model, there was a statistically significant difference between the HBCTR group versus the control group (MD − 2.88, 95%CI − 5.19 to − 0.57, P = 0.01), but not in diastolic blood pressure. Likewise, significant improvements of triglycerides and in low-density lipoprotein cholesterol were observed in HBTCR groups, but no significant differences were observed regarding total cholesterol and high-density lipoprotein cholesterol. Conclusion This systematic review and meta-analysis have proven that the HBCTR is one of the promisingly effective cardiac rehabilitation strategies that improve cardiorespiratory fitness and reduce cardiovascular disease risk factors. With the continuous improvement of the telerehabilitation network, it is expected to serve in clinical.

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Section: Discussionmentioning

confidence: 99%

Effects of home-based cardiac telerehabilitation programs in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Zhang

et al. 2023

BMC Cardiovasc Disord

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“…Statin therapy has also been shown to lower GlycA levels in separate clinical studies but the magnitude of change was surprisingly modest [ 84 , 85 ]. A randomized controlled trial on 10-month cardiac telerehabilitation demonstrated improved GlycA (from 840.7 to 758.2 umol/L, p = 0.007), GlycB (from 406.5 to 369.9 umol/L, p = 0.002) and lipoprotein particle profile, [ 86 ] and superiority over center-based cardiac rehabilitation. Further evidence of an intervention having significant impact on GlycA lowering has come from a study of obese patients undergoing bariatric surgery that showed an average of 22% reduction, and a strong association with HDL particle size ( r = -0.49, p < 0.001) that explained 43% of body weight loss [ 87 ].…”

Section: Impact Of Interventions On Glyca and Glycb Levelsmentioning

confidence: 99%

Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates

Fung,

Chan,

et al. 2023

J Inflamm

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Summary Cardiometabolic diseases are associated with low-grade inflammation early in life and persists into old age. The long latency period presents opportunities for early detection, lifestyle modification and intervention. However, the performance of conventional biomarker assays to detect low-grade inflammation has been variable, particularly for early-stage cardiometabolic disorder including prediabetes and subclinical atherosclerotic vascular inflammation. During the last decade, the application of nuclear magnetic resonance (NMR) spectroscopy for metabolic profiling of biofluids in translational and epidemiological research has advanced to a stage approaching clinical application. Proton (1H)-NMR profiling induces no destructible physical changes to specimens, and generates quantitative signals from deconvoluted spectra that are highly repeatable and reproducible. Apart from quantitative analysis of amino acids, lipids/lipoproteins, metabolic intermediates and small proteins, 1H-NMR technology is unique in being able to detect composite signals of acute-phase and low-grade inflammation indicated by glycosylated acetyls (GlycA) and N-acetylneuraminic acid (sialic acid) moieties (GlycB). Different from conventional immunoassays that target epitopes and are susceptible to conformational variation in protein structure and binding, GlycA and GlycB signals are stable over time, and maybe complementary as well as superior to high-sensitivity C-reactive protein and other inflammatory cytokines. Here we review the physicochemical principles behind 1H-NMR profiling of GlycA and GlycB, and the available evidence supporting their potential clinical application for the prediction of incident (pre)diabetes, cardiovascular disease, and adverse outcomes.

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“…They focus on an integrated approach to individualised lifestyle interventions including systematic use of a ‘FITT’ prescription for exercise training referring guidance on the frequency, intensity, time and type of exercise performed, and use of personalised exercise goals. Many patients, especially those who are high-risk, will benefit from supervised in-hospital programmes however home-based and remote cardiac rehabilitation programmes have been shown to be effective and safe, with minimal adverse events [ 135 , 136 ].…”

Section: Exercise In Patients With Cardiovascular Diseasementioning

confidence: 99%

Exercise and the Heart: Benefits, Risks and Adverse Effects of Exercise Training

Mannakkara¹,

Finocchiaro²

2023

Rev. Cardiovasc. Med.

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Exercise has multiple health benefits and reduces cardiovascular morbidity and mortality. Regular exercise decreases the burden of cardiovascular risk factors and improves prognosis in several cardiac conditions. Despite these premises, sudden cardiac death (SCD) during sports may occur in apparently healthy athletes who perform at the highest levels. Accurate identification and prompt treatment of individuals at risk may reduce the burden of SCD. A possible cardiotoxic effect of intense exercise has been recently postulated, however this is still matter of controversy as causal relationships are often difficult to establish taking into account multiple confounders. Exercise is safe for the majority, even with cardiovascular disease. In this review, we focus on exercise and sports, discussing their benefits and risks and exercise recommendations for healthy individuals and those with cardiovascular disease.

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Cardiac telerehabilitation with long-term follow-up reduces GlycA and improves lipoprotein particle profile: A randomised controlled trial

Cited by 8 publications

References 18 publications

Effects of home-based cardiac telerehabilitation programs in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Effects of home-based cardiac telerehabilitation programs in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates

Exercise and the Heart: Benefits, Risks and Adverse Effects of Exercise Training

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