Cardiac telomere attrition following changes in the expression of shelterin genes in pulmonary hypertensive chickens

Hassanpour, Hossein; Farhadi, Navid; Bahadoran, Shahab; Akbari, Mohammad Reza

doi:10.1080/00071668.2022.2163877

Cited by 1 publication

(2 citation statements)

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“…Using LinRegPCR software, version 2012.0 (Amsterdam, Netherlands), the threshold cycle number (Ct) of PCR and mean efficiency values (E) for telomere and GAPDH were calculated. According to Hassanpour et al (2023) [5] and Pfaffl (2001) [13], the relative telomere length was computed. Using this technique, each sample's telomere length was measured for GAPDH.…”

Section: Genomic Dna Extraction and Telomere Length Analysis By Quant...mentioning

confidence: 99%

“…They consist of both proximal double-stranded and distal single-stranded portions. These areas, in conjunction with shelterin proteins, protect the ends of chromosomes, preserving the genome's integrity [5]. Telomeres experience age-related gradual attrition as a result of the intrinsic constraints of DNA replication and the inhibition of telomerase in the majority of somatic cells.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Licorice on Serum Lipid Peroxidation and Telomere Length of Immune Cells in Japanese Quail (as an Animal Model) Following Vaccination by Salmonella Bacterin

Tohidifar,

Tavakoli,

Hassanpour

et al. 2023

Immunoregulation

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Background: Bacterin-based vaccination may be a stressful condition, leading to harmful effects, such as high lipid peroxidation and telomere shortening. This study aimed to reduce these probable side effects via the administration of different concentrations of licorice (because of its anti-oxidative and anti-aging properties). Materials and Methods: Japanese quails as animal models were reared for 42 days under standard conditions. The birds were divided into eight groups, including a control group, licorice treatments (licorice 0.02%, Licorice 0.04%, and licorice 0.08% groups), and Salmonella bacterin treatments (bacterin, bacterin+licorice 0.02%, bacterin+licorice 0.04%, and bacterin+licorice 0.08% groups). The Salmonella enterica bacterin-based vaccine was injected twice on days 14 and 28. Serum lipid peroxidation and telomere length of immune cells in all experimental groups were measured. Results: Lipid peroxidation and telomere shortening enhanced following bacterin vaccination. Licorice at doses of 0.04%, 0.08%, or both reduced the lipid peroxidation and telomere shortening in non-vaccinated and vaccinated birds, while the dose of 0.02% was not effective. Conclusion: This study confirmed the side effects of high lipid peroxidation and telomere attrition for S. enterica bacterin-based vaccination. Also, the improving properties of licorice for these side effects were considered to be effective.

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Section: Genomic Dna Extraction and Telomere Length Analysis By Quant...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Licorice on Serum Lipid Peroxidation and Telomere Length of Immune Cells in Japanese Quail (as an Animal Model) Following Vaccination by Salmonella Bacterin

Tohidifar,

Tavakoli,

Hassanpour

et al. 2023

Immunoregulation

View full text Add to dashboard Cite

show abstract

Cardiac telomere attrition following changes in the expression of shelterin genes in pulmonary hypertensive chickens

Cited by 1 publication

References 46 publications

The Effect of Licorice on Serum Lipid Peroxidation and Telomere Length of Immune Cells in Japanese Quail (as an Animal Model) Following Vaccination by Salmonella Bacterin

The Effect of Licorice on Serum Lipid Peroxidation and Telomere Length of Immune Cells in Japanese Quail (as an Animal Model) Following Vaccination by Salmonella Bacterin

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