Cardiac Tissue Engineering

Hirt, Marc N.; Hansen, Arne; Eschenhagen, Thomas

doi:10.1161/circresaha.114.300522

Cited by 364 publications

(307 citation statements)

References 97 publications

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“…[4][5][6][7] In addition to its direct therapeutic value to patients, cord blood is used for basic research on blood, blood stem cells, and immune cells. There are several advantages and disadvantages to different HSC sources, and no single source is "best" in all circumstances for all patients.…”

Section: Discussionmentioning

confidence: 99%

Challenges to the Sustainability of the U.S. Public Cord Blood System

Kapinos¹,

Briscombe²,

Gračner³

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Challenges to the Sustainability of the U.S. Public Cord Blood System

Kapinos¹,

Briscombe²,

Gračner³

et al. 2017

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“…The regeneration ability of the myocardium tissue is limited as the myocytes cease proliferation when they are mature and differentiated. [86] Tissue engineering approaches have aimed to fabricate this structurally complicated and functionally important tissue, and beating patches of heart tissue can already be produced in the lab. [87] Extrusion bioprinting to coprint human vascular endothelial cells (HUVECs) and cardiac cells has been used to form tissue spheroids.…”

Section: Cardiac Tissuesmentioning

confidence: 99%

Organ Bioprinting: Are We There Yet?

Gao

Huang

Schilling

et al. 2017

Adv Healthcare Materials

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About 15 years ago, bioprinting was coined as one of the ultimate solutions to engineer vascularized tissues, which was impossible to accomplish using the conventional tissue fabrication approaches. With the advances of 3D‐printing technology during the past decades, one may expect 3D bioprinting being developed as much as 3D printing. Unfortunately, this is not the case. The printing principles of bioprinting are dramatically different from those applied in industrialized 3D printing, as they have to take the living components into account. While the conventional 3D‐printing technologies are actually applied for biological or biomedical applications, true 3D bioprinting involving direct printing of cells and other biological substances for tissue reconstruction is still in its infancy. In this progress report, the current status of bioprinting in academia and industry is subjectively evaluated. The progress made is acknowledged, and the existing bottlenecks in bioprinting are discussed. Recent breakthroughs from a variety of associated fields, including mechanical engineering, robotic engineering, computing engineering, chemistry, material science, cellular biology, molecular biology, system control, and medicine may overcome some of these current bottlenecks. For this to happen, a convergence of these areas into a systemic research area “3D bioprinting” is needed to develop bioprinting as a viable approach for creating fully functional organs for standard clinical diagnosis and treatment including transplantation.

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“…For example, several approaches for engineering cardiac cell "sheets" or "patches" that can be implanted onto hearts in vivo have been demonstrated and shown to mitigate damage induced by myocardial infarction and ischemia. [82][83][84][85] Approaches for engineering other types of vascularized tissue, such as bone, kidney, and pancreas, have also met with significant success. [86][87][88] Many others have cataloged the progress of tissue engineering and the advances in manufacturing technologies and novel materials that have rendered possible medical applications of biofabrication.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Raman

Bashir

2017

Adv Healthcare Materials

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how the concept of bioinspiration, or imitating biological design and functionality in synthetic materials, created a new class of "smart" biomimetic materials. Then, we shall discuss how the continuing development of enabling manufacturing technologies, such as 3D printing and microfluidics, has established the separate subdiscipline of biofabrication for tissue engineering, or "building with biology." Finally, we shall investigate the convergence of these two fields into the emerging discipline of biohybrid design, the use of biological materials to power non-natural functional behaviors in synthetic machines. Throughout this report, we will revisit a single class of materials, hydrogels, as a case study of biological design in the context of each subfield, and discuss how the constraints, underlying principles, and end-use applications differ in each case. We will also discuss ethical considerations of biological design, with a special focus on forward engineering non-natural or hypernatural functional behaviors in biohybrid systems. We will conclude with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practices for the next generation of engineers and scientists. Biomimicry and Bioinspired DesignA deeper understanding of the underlying design principles that govern biological systems has inspired the field of biomimicry. [1,2] Observing adaptive phenomena in nature, scientists and engineers have sought to extract the components of biological design responsible for this behavior and replicate the behavior in synthetic materials. Fundamentally, this involves understanding the building blocks or base units from which a biological material is built, the hierarchical assembly of these building blocks, and the interactions and interfaces between them.In this section, we will discuss strategies that engineers and scientists have employed to engineer bioinspired hierarchy, from bottom-up self-assembly and top-down engineered assembly. We will present several key demonstrations of stimulus-responsive hydrogels ranging from the micro-to the macroscale, and investigate novel demonstrations in biomimetic actuation and movement. We will conclude with the remaining challenges in the field of biomimicry and discuss the potential future impact of bioinspired design.The discipline of biological design has a relatively short history, but has undergone very rapid expansion and development over that time. This Progress Report outlines the evolution of this field from biomimicry to biofabrication to biohybrid systems' design, showcasing how each subfield incorporates bioinspired dynamic adaptation into engineered systems. Ethical implications of biological design are discussed, with an emphasis on establishing responsible practices for engineering non-natural or hypernatural functional behaviors in biohybrid systems. This report concludes with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practice...

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Cardiac Tissue Engineering

Cited by 364 publications

References 97 publications

Challenges to the Sustainability of the U.S. Public Cord Blood System

Challenges to the Sustainability of the U.S. Public Cord Blood System

Organ Bioprinting: Are We There Yet?

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

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