Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty

Saunders, Ashley B.; Smith, Brooke E.; Fosgate, Geoffrey T.; Suchodolski, Jan S.; Steiner, Jörg M.

doi:10.1016/j.jvc.2009.04.002

Cited by 22 publications

(26 citation statements)

References 31 publications

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“…The pulmonic PG, which indicates hemodynamic severity of stenosis [23], was not correlated with vertebral heart score and PA/Ao ratio. In contrast, the pulmonic PG was positively correlated with cardiothoracic ratio ( r =0.46, P <0.013; Table 3…”

Section: Resultsmentioning

confidence: 99%

“…These results suggest that ventricular pressure overload stimulate the synthesis and secretion of BNP and NT-proBNP into circulation [5, 13, 27]. Although Saunders et al reported that serum concentration of cardiac troponin I increased in 7 of 23 dogs with severe PS [23], however, no information has previously been reported regarding plasma NT-proBNP concentrations in dogs with PS. In the present study, we firstly demonstrated that plasma NT-proBNP concentration in dogs with symptomatic PS was significantly higher than those of healthy controls and dogs with asymptomatic PS.…”

Section: Discussionmentioning

confidence: 99%

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Plasma N-Terminal Pro B-Type Natriuretic Peptide Concentrations in Dogs with Pulmonic Stenosis

Kobayashi

Hori

Chimura

2014

The Journal of Veterinary Medical Science

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The detailed information between plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations and dogs with pulmonic stenosis (PS) is still unknown. The aim of the present study was to investigate the clinical utility of measuring plasma NT-proBNP concentrations in dogs with PS and to determine whether plasma NT-proBNP concentration could be used to assess disease severity. This retrospective study enrolled 30 client-owned, untreated dogs with PS (asymptomatic [n=23] and symptomatic [n=7]) and 11 healthy laboratory beagles. Results of physical examination, thoracic radiography and echocardiography were recorded. Plasma NT-proBNP concentrations were measured using commercial laboratories. Compared to the healthy control dogs, cardiothoracic ratio was significantly increased in dogs with both asymptomatic and symptomatic PS. Similarly, the ratio of the main pulmonary artery to aorta was significantly decreased in dogs with both asymptomatic and symptomatic PS. The pulmonic pressure gradient in the symptomatic PS dogs was significantly higher than that in the asymptomatic PS dogs. Plasma NT-proBNP concentration was significantly elevated in the symptomatic PS dogs compared to the healthy control dogs and the asymptomatic PS dogs. Furthermore, the Doppler-derived pulmonic pressure gradient was significantly correlated with the plasma NT-proBNP concentration (r=0.78, r2=0.61, P<0.0001). Plasma NT-proBNP concentration >764 pmol/l to identify severe PS had a sensitivity of 76.2% and specificity of 81.8%. The plasma NT-proBNP concentration increased by spontaneous PS, i.e. right-sided pressure overload and can be used as an additional method to assess the severity of PS in dogs.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma N-Terminal Pro B-Type Natriuretic Peptide Concentrations in Dogs with Pulmonic Stenosis

Kobayashi

Hori

Chimura

2014

The Journal of Veterinary Medical Science

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“…31e42 Use of cTnI concentration to specifically assess the right heart in PH and pulmonic stenosis has been described. 43,44 To our knowledge, there have been no veterinary studies systematically evaluating cardiac biomarkers in dogs solely with pre-capillary PH.…”

Section: Bnpmentioning

confidence: 99%

NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension

Kellihan

MacKie²,

Stepien

2011

Journal of Veterinary Cardiology

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“…La proteína c reactiva (pcr), que evalúa inflamación del sistema cardiovascular, usada en el diagnóstico y pronóstico del infarto agudo de miocardio en humanos [13].…”

Section: Tipos De Biomarcadores Cardiacosunclassified

Biomarcadores cardiacos como ayuda diagnóstica en las cardiopatías

Salgado

Arango

2014

Spei Domus

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En la clínica diaria de pequeños animales, es común encontrarse con patologías cardiacas, para cuyo diagnóstico se utilizan técnicas imagenológicas como la radiografía, el electrocardiograma y la ecocardiografía. Sin embargo, a pesar de la amplia investigación sobre estas técnicas, todavía es difícil establecer con claridad el pronóstico de estos pacientes y evaluar objetivamente la evolución de dichas patologías; incluso, existen pacientes con cardiopatías ocultas que pueden pasar inadvertidas al examen clínico y a las ayudas imagenológicas. Es por este motivo que en los últimos años se vienen estudiando nuevos métodos para diagnosticar cardiopatías de forma rápida y eficaz; es el caso de los biomarcadores cardiacos, como las troponinas y los péptidos natriuréticos, que en medicina humana y animal se usan cada vez más para ayudar a establecer el diagnóstico, el pronóstico y la evolución de problemas cardiacos, con alta especificidad y sensibilidad. El presente artículo pretende actualizar los conceptos sobre el manejo de biomarcadores cardiacos en el diagnóstico cardiológico de perros y gatos.

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Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty

Cited by 22 publications

References 31 publications

Plasma N-Terminal Pro B-Type Natriuretic Peptide Concentrations in Dogs with Pulmonic Stenosis

Plasma N-Terminal Pro B-Type Natriuretic Peptide Concentrations in Dogs with Pulmonic Stenosis

NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension

Biomarcadores cardiacos como ayuda diagnóstica en las cardiopatías

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