Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis

Geddes, Jacqueline; Deans, Kevin A.; Cormack, Alistair; Motherwell, D.W.; Paterson, Ken; O'Reilly, D.; Fisher, BM

doi:10.1258/000456307780945750

Cited by 16 publications

(4 citation statements)

References 7 publications

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“…In our study, we found that serum level of cTnT I was significantly higher in diabetic children than healthy control that presented an evidence of ongoing myocardial injury caused by uncontrolled DM in these children. Similar results were obtained by other investigators . Interestingly, there was no significant correlation between cTnT I levels and various echocardiographic parameters.…”

Section: Discussionsupporting

confidence: 91%

Three‐dimensional speckle tracking echocardiography: Is it the magic wand in the diagnosis of subclinical myocardial dysfunction in children with type 1 diabetes mellitus?

et al. 2018

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Section: Discussionsupporting

confidence: 91%

Three‐dimensional speckle tracking echocardiography: Is it the magic wand in the diagnosis of subclinical myocardial dysfunction in children with type 1 diabetes mellitus?

et al. 2018

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“…These clinical conditions usually cause myocardial necrosis owing to a supply–demand mismatch or direct myocardial toxicity. Diabetic ketoacidosis (DKA) is another condition that can lead to myocardial necrosis in the absence of coronary artery disease (CAD) and has been the subject of previous case reports [1, 2], case series [3], and retrospective reviews [4, 5]. The present case report contributes to the reported data regarding this finding, which has prognostic implications.…”

mentioning

confidence: 60%

Elevated Troponin I Levels in Diabetic Ketoacidosis Without Obstructive Coronary Artery Disease

Manikkan

2018

Journal of the Endocrine Society

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Elevated troponin levels have been observed in a wide spectrum of patients who do not have ischemic heart disease, including nonacute coronary syndrome and cardiovascular and noncardiovascular conditions. The cases of two patients with diabetic ketoacidosis who had elevated troponin levels in the absence of coronary artery disease are presented. This clinical scenario can pose a diagnostic dilemma for the physician. The objective of the present report is to highlight the mechanism of troponin elevation in patients with diabetic ketoacidosis, in addition to the clinical and prognostic significance of this finding.

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“…Our results suggest that a higher methylation level of the TNNT1 gene in high responders compared with low responders could lead to a lower gene transcription rate in those adolescents, allowing them to obtain greater benefits from the weight loss intervention. In regard to the TNNI3 gene, minor troponin I elevations appear to occur in a small number of subjects with type 1 diabetes presenting ketoacidosis (36), but its implication in obesity is still not clear.…”

Section: Discussionmentioning

confidence: 99%

Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study

et al. 2013

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In recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human's lifetime. The objective of this work was to explore baseline changes in DNA methylation that could be associated with a better weight loss response after a multidisciplinary intervention program in Spanish obese or overweight adolescents. Overweight or obese adolescents (n=107) undergoing 10 wk of a multidisciplinary intervention for weight loss were assigned as high or low responders to the treatment. A methylation microarray was performed to search for baseline epigenetic differences between the 2 groups (12 subjects/group), and MALDI‐TOF mass spectrometry was used to validate (n=107) relevant CpG sites and surrounding regions. After validation, 5 regions located in or near AQP9, DUSP22, HIPK3, TNNT1, and TNNI3 genes showed differential methylation levels between high and low responders to the multidisciplinary weight loss intervention. Moreover, a calculated methylation score was significantly associated with changes in weight, BMI‐SDS, and body fat mass loss after the treatment. In summary, we have identified 5 DNA regions that are differentially methylated depending on weight loss response. These methylation changes may help to better understand the weight loss response in obese adolescents.—Moleres, A., Campión, J., Milagro, F. I., Marcos, A., Campoy, C., Garagorri, J. M., Gómez‐Martínez, S., Martínez, J. A., Azcona‐Sanjulián, M. C., Martí, A. Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study. FASEB J. 27, 2504–2512 (2013). http://www.fasebj.org

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Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis

Abstract: Minor troponin elevations appear to occur in a small number of subjects with type 1 diabetes presenting with DKA. The clinical relevance of this at this stage remains unknown and further large-scale studies are suggested.

Cited by 16 publications

References 7 publications

Three‐dimensional speckle tracking echocardiography: Is it the magic wand in the diagnosis of subclinical myocardial dysfunction in children with type 1 diabetes mellitus?

Three‐dimensional speckle tracking echocardiography: Is it the magic wand in the diagnosis of subclinical myocardial dysfunction in children with type 1 diabetes mellitus?

Elevated Troponin I Levels in Diabetic Ketoacidosis Without Obstructive Coronary Artery Disease

Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study

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