Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction

Abstract

Objective To investigate changes in serum cardiac troponin I (cTnI) concentrations in dogs in which medetomidine was used for sedation or for premedication prior to anaesthesia with propofol and sevoflurane. Study design Prospective clinical study.Animals A total of 66 client-owned dogs. MethodsThe dogs were sedated with medetomidine (0.04 mg kg -1 ) intravenously (IV) (group M; n = 20) and left to breath room air or anaesthetized with propofol (6.5 ± 0.76 mg kg -1 IV) and sevoflurane (4.5% vaporizer setting) in oxygen (group P+S; n = 20) or with medetomidine (0.04 mg kg -1 IV), propofol (1.92 ± 0.63 mg kg -1 ) and sevoflurane (3% vaporizer setting) in oxygen (group M+P+S; n = 26), respectively. After 35 minutes, medetomidine was antagonized with atipamezole (0.1 mg kg -1 intramuscularly). Blood samples for serum cTnI determination were taken before sedation or anaesthesia, 6 and 12 hours and 4 days thereafter. Serum cTnI concentrations were measured with the Architect STAT Troponin-I assay.Results Before sedation or anaesthesia, cTnI concentrations were above the detection limit in 22 out of 66 (33%) of dogs. Compared to basal values, cTnI concentrations significantly increased at 6 and 12 hours in all groups and at day 4 in group M. There were no differences in cTnI concentration between groups at baseline, at 6 hours and at 4 days. At 12 hours, cTnI concentrations were significantly higher in groups M and P+S, respectively, compared to group M+P+S. Conclusions and clinical relevanceOxygenation during anaesthesia and reduction of propofol and sevoflurane dose due to the sparing effects of medetomidine might have

Systemic Effects and Clinical Application of Medetomidine in Animals: A Review

“…Rioja et al (2013) reported that the low dose CRI of medetomidine (1 µgm/kg bodyweight/ hour) during ovariohysterectomy in healthy dog induced minimum and acceptable change in CO and allow 17% less MAC recommended for isoflurane in dogs. Premedication with medetomidine during propofol or sevoflurane cause less subclinical myocardial damage which was evidenced by short-lived increased serum troponin1 (cTnI) concentrations in dog with comparison to without premedication (Vasiljevic et al, 2018).…”

The Effect of a Subsequent Dose of Dexmedetomidine or Other Sedatives following an Initial Dose of Dexmedetomidine on Electrolytes, Acid–Base Balance, Creatinine, Glucose, and Cardiac Troponin I in Cats: Part II

“…Cardiac troponin I (cTnI) is responsible for actin-myosin inhibition during calcium shortage; troponin T (cTnT) binds to tropomyosin and binds it, whereas troponin C (cTnC) binds calcium to inhibit contraction [27][28][29]. It has been reported that the administration of a 2 -agonists does not alter [30] or increase the concentration of cTnI [31,32] in small animals. Hence, the effect of dexmedetomidine and other commonly administered sedative drugs on myocardial function can be easily and non-invasively assessed by measuring specific cardiac biomarkers such as cTnI in cats [27,31].…”

Orşiektomi Yapılan Sedasyonlu Köpeklerde Epidural Deksmedetomidinin Fizibilite, Reverzibilite ve Kardiyorespiratuvar Etkilerinin Değerlendirilmesi

“…Dexmedetomidine is used as a sedative and an analgesic in small animals [12] . When used as a premedication in dogs, intravenous administration and/or infusion of DEX decreased propofol and inhalation anesthetic requirement in a dose-dependent manner [13][14][15][16] . Epidural administration of DEX in isoflurane-anesthetized dogs has also had a dose-related MAC-sparing effect [17] .…”