Cardiac troponin I in sickle cell crisis

Aslam, Ahmad Kamal; Rodríguez, Carlos J.; Aslam, Ahmed F.; Vasavada, Balendu C.; Khan, Ijaz A.

doi:10.1016/j.ijcard.2007.08.135

Cited by 16 publications

(16 citation statements)

References 3 publications

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“…In patients with transfusion-dependent diseases such as major thalassemia, troponin I has not been identified as predictive of progressive iron overload or echocardiographic abnormalities (286). Troponin elevations appear infrequent in patients with sickle cell crisis (287,288) and may represent consequences of pulmonary hypertension associated with acute chest syndrome (289), though frank MI has been reported (290).…”

Section: Appendix 1 Relevant Author Relationships With Industry and mentioning

confidence: 99%

ACCF 2012 Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations

Newby

Jesse²,

Babb³

et al. 2012

Journal of the American College of Cardiology

347

134

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Section: Appendix 1 Relevant Author Relationships With Industry and mentioning

confidence: 99%

ACCF 2012 Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations

Newby

Jesse²,

Babb³

et al. 2012

Journal of the American College of Cardiology

347

134

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“…measured troponin-I levels at baseline, 6 and 12-hours post-admission. (45) Only 2 of the 32 patients had a positive test indicating myocardial injury (with echocardiographic evidence of LV dysfunction in 1 patient) suspected to be due to microvascular obstruction and both the patients exhibited features of acute chest syndrome. In a subsequent report, Lippi et al observed elevation of the MB isoform of creatine kinase but no troponin-T elevation during sickle cell crisis (without acute chest syndrome) in comparison to levels during stable disease state.…”

Section: Diagnostic Techniques To Detect Myocardial Ischemia or Infarmentioning

confidence: 99%

Myocardial Infarction in Sickle Cell Disease: Use of Translational Imaging to Diagnose an Under-Recognized Problem

Chacko

Kraut

Zweíer

et al. 2012

J. of Cardiovasc. Trans. Res.

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Sickle cell disease (SCD) is an inherited disorder in which microvascular occlusion causes complications across multiple organ systems. The precise incidence of myocardial ischemia and infarction (MI), potentially under-recognized microvascular disease-related complications, remains unknown. The absence of typical atherosclerotic lesions seen in other patients with MI suggests a microvascular mechanism of myocardial injury. Cardiac magnetic resonance (CMR) can demonstrate microvascular disease, making it an appealing modality to assess symptomatic SCD patients. We demonstrate in several dramatic instances how CMR uniquely able to depict cardiac microvascular obstruction in patients with SCD and chest pain, without which the possibility of myocardial injury would almost certainly be otherwise neglected. Much remains unknown regarding ischemic heart disease in patients with SCD including prevalence, detection and management. Further work to define evaluation and management algorithms for chest pain in SCD and to develop risk assessment tools may reduce sudden cardiac death in this population.

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“…, Aslam et al . ). Further evidence of the relationship between anaemia and cardiac damage comes from studies that demonstrate a correlation between serum cTnI concentration and the severity of the anaemic state (Diniz et al .…”

Section: Discussionmentioning

confidence: 97%

Serum cardiac troponin I concentrations decrease following treatment of primary immune‐mediated haemolytic anaemia

Cartwright

Gow

et al. 2015

J of Small Animal Practice

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Cardiac troponin I in sickle cell crisis

Cited by 16 publications

References 3 publications

ACCF 2012 Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations

ACCF 2012 Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations

Myocardial Infarction in Sickle Cell Disease: Use of Translational Imaging to Diagnose an Under-Recognized Problem

Serum cardiac troponin I concentrations decrease following treatment of primary immune‐mediated haemolytic anaemia

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