1998
DOI: 10.1016/s1010-7940(97)00304-7
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Cardiac troponin I plasma levels for diagnosis and quantitation of perioperative myocardial damage in patients undergoing coronary artery bypass surgery

Abstract: cTnI qualifies as a marker for diagnosis of PMI and quantitation of the amount of myocardial damage, because of the availability of a quick diagnostic test with high specificity, the high diagnostic efficiency, and especially the sufficient information gained by a single determination 24 h after aortic unclamping.

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Cited by 92 publications
(52 citation statements)
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“…That the between-group difference failed to achieve statistical significance can be explained by (1) the small sample size and (2) the already low levels of troponin I yielded by our control patients, which makes more difficult the demonstration of a further significant improvement. Thus, in this group, the 24-hour postoperative value averaged 4.4 g/L, which compares favorably with the value of 5.2 g/L reported at the same time point by Sadony and coworkers 30 in patients classified as having minor myocardial damage. Likewise, the peak value observed (at 6 hours postoperatively) in our series (5.8 g/L) is much lower than the cutoff value (13.4 g/L) shown by Jacquet and associates 31 to significantly separate those patients with an uneventful recovery from those with ischemia/infarction.…”
Section: Ii-342supporting
confidence: 88%
“…That the between-group difference failed to achieve statistical significance can be explained by (1) the small sample size and (2) the already low levels of troponin I yielded by our control patients, which makes more difficult the demonstration of a further significant improvement. Thus, in this group, the 24-hour postoperative value averaged 4.4 g/L, which compares favorably with the value of 5.2 g/L reported at the same time point by Sadony and coworkers 30 in patients classified as having minor myocardial damage. Likewise, the peak value observed (at 6 hours postoperatively) in our series (5.8 g/L) is much lower than the cutoff value (13.4 g/L) shown by Jacquet and associates 31 to significantly separate those patients with an uneventful recovery from those with ischemia/infarction.…”
Section: Ii-342supporting
confidence: 88%
“…The diagnostic threshold values and the validity of biochemical markers in this setting have been debated [27][28][29][30] . In several recent trials, the outcome was mainly dependent on the biochemical markers (Impact II, PURSUIT, Epistent [31,32] ).…”
Section: Discussionmentioning
confidence: 99%
“…[2][3][4][5] Repetitive measurements of cardiac markers may probably allow a better assessment of their postoperative release. Sadony et al [6] reported that a cardiac troponin I value at 24 th hour had a sensitivity of 100% and a specificity of 97% for the discrimination of patients with and without perioperative myocardial infarction. Thus, we evaluated troponin levels at 24 hours following the intervention.…”
Section: Author Replymentioning
confidence: 99%