Cardiac troponin levels in pregnant women with severe pre-eclampsia

Abstract

Pre-eclampsia is a multisystem disorder that involves vascular endothelial dysfunction and diffuse inflammatory response. The cardiac troponin (cTn-I) levels in pre-eclampsia are controversial. The objective of this study was to compare the cTn-I levels between normal pregnant women and those with severe pre-eclampsia. A total of 78 patients who underwent caesarean section were included in the study. The patients were assigned into two groups as the severe pre-eclamptic pregnant group (study group, n = 36) and normotensive pregnant group (control group, n = 42).The cTn-I levels of all patients were measured preoperatively and postoperatively. A statistically significant difference was not determined between the preoperative and postoperative cTn-I levels (p > 0.05) between the two groups. In the present study, a relation was not determined between pre-eclampsia and increased cTn-I levels. If high cTn-I levels are determined in pre-eclamptic patients, other pathologies that may cause myocardial damage should be investigated.

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

“…Two studies on c‐Tn1 described elevated levels in pre‐eclampsia compared with controls,97, 98 of which only one with statistically significant result 97…”

High-sensitivity troponin T predicts worsening of albuminuria in hypertension; results of a nested case–control study with confirmation in diabetes

“…TnT has generally been considered a marker for cardiomyocyte necrosis. However, hs-TnT has also been detected in noncardiac conditions, including renal failure, pulmonary hypertension, pulmonary embolism, sepsis and dialysis, albeit in substantially lower concentrations [23][24][25][26][27]. The findings of hs-TnT levels in this low range in conditions other than cardiac ischemia indicate that even the low levels may confer prognostic information.…”

Troponina i en preeclampsia y eclampsia

“…De igual forma, Aydin et al 19 tampoco encontraron diferencias significativas en las concentraciones del marcado entre las preeclámpticas severas y los controles sanos. Las posibles causas de esta diferencia con los resultados de esta y otras investigaciones pueden ser por las diferentes características de las pacientes, como enfermedades sistémicas concomitantes o estado del volumen intravascular.…”