Cardiac troponin T and NT-proBNP for detecting myocardial ischemia in suspected chronic coronary syndrome

Myhre, Peder L.; Røsjø, Helge; Sarvari, Sebastian Imre; Ukkonen, Heikki; Rademakers, Frank; Engvall, Jan; Hagve, Tor-Arne; Nagel, Eike; Sicari, Rosa; Zamorano, José Luís; Monaghan, Mark; D'hooge, Jan; Edvardsen, Thor; Omland, Torbjørn

doi:10.1016/j.ijcard.2022.05.027

International Journal of Cardiology

2022

DOI: 10.1016/j.ijcard.2022.05.027

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Cardiac troponin T and NT-proBNP for detecting myocardial ischemia in suspected chronic coronary syndrome

Peder L. Myhre¹,

Helge Røsjø²,

Sebastian Imre Sarvari³

et al.

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2023

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L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy

Doss¹,

Nagarajan²

2023

Asian Pacific Journal of Tropical Biomedicine

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Objective: To explore the therapeutic efficacy of L-carvone from Mentha spicataL. leaf extracts against isoproterenol-induced cardiac hypertrophy in rats. Methods: Isoproterenol (5 mg/kg) was injected intraperitoneally into rats for one month to induce cardiac hypertrophy. L-carvone (25 and 100 mg/kg) was administered orally to treat cardiac hypertrophy. The cardioprotective activity of L-carvone was evaluated by electrocardiogram, histopathological analysis as well as determination of biochemical parameters and enzymatic markers. Results: L-carvone from Mentha spicata L. at 25 and 100 mg/kg ameliorated isoproterenol-induced cardiac hypertrophy, as evidenced by reduced QRS interval on electrocardiogram, and decreased heart weight and heart index. In addition, both doses of L-carvone markedly lowered the levels of glucose, total protein, low-density lipoprotein cholesterol, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatine kinase MB, troponin-I, N-terminal pro-B type natriuretic peptide and triglycerides while increasing high-density lipoprotein cholesterol and lipase level (P<0.05). Moreover, L-carvone alleviated contraction band necrosis, and reorganized the myofibrils with normal striations and myocytes as well as normal nuclei in cardiac histoarchitecture of rats with isoproterenol-induced cardiac hypertrophy. Conclusions: L-carvone from Mentha spicata L. leaf extract can restore abnormal cardiac function and may be further explored as a therapeutic agent against the deleterious effects of cardiac hypertrophy after further evaluation.

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L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy

Doss¹,

Nagarajan²

2023

Asian Pacific Journal of Tropical Biomedicine

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Cardiac troponin T and NT-proBNP for detecting myocardial ischemia in suspected chronic coronary syndrome

Cited by 1 publication

References 16 publications

L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy

L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy

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