Cardiac Troponins in Pediatrics

Kanaan, Usama; Chiang, Vincent W.

doi:10.1097/01.pec.0000125664.35690.51

Cited by 28 publications

(16 citation statements)

References 47 publications

(100 reference statements)

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“…These ranges appear to require at least one standard deviation above the normal reference range, depending on specific assay characteristics. Additionally, troponin measurements in the perinatal period and in premature infants may be limited by these issues (92)(93)(94)(95)(96)(97). These factors reinforce the recommendation for serial measurements in the neonatal period.…”

Section: Troponin In Pediatricsmentioning

confidence: 82%

Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance

Domico¹,

Checchia²

2011

Pediatric Critical Care Medicine

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Section: Troponin In Pediatricsmentioning

confidence: 82%

Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance

Domico¹,

Checchia²

2011

Pediatric Critical Care Medicine

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“…In a pediatric HTx population (n ϭ 9), the predictive power of a single cTnT measurement was not sufficient to replace biopsy (92 ). cTn measurement has not shown utility in assessing CAV in pediatric HTx recipients (93 ).…”

Section: Iatrogenic Conditions Invasive Proceduresmentioning

confidence: 99%

“…In an investigation of a series of 73 elective corrections of cardiac defects, the prediction of severe postoperative complications during the first 24 h in the ICU showed a positive predictive value of 100% and a negative predictive value of 93% with the use of a cTnI threshold of 35 g/L (96 ). Systematic review of data suggests that preoperative increases in cTn preceding congenital heart defect repair are a poor prognostic sign (93 ).…”

Section: Iatrogenic Conditions Invasive Proceduresmentioning

confidence: 99%

Increases of Cardiac Troponin in Conditions other than Acute Coronary Syndrome and Heart Failure

2009

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Background: Although cardiac troponin (cTn) is a cornerstone marker in the assessment and management of patients with acute coronary syndrome (ACS) and heart failure (HF), cTn is not diagnostically specific for any single myocardial disease process. This narrative review discusses increases in cTn that result from acute and chronic diseases, iatrogenic causes, and myocardial injury other than ACS and HF.Content: Increased cTn concentrations have been reported in cardiac, vascular, and respiratory disease and in association with infectious processes. In cases involving acute aortic dissection, cerebrovascular accident, treatment in an intensive care unit, and upper gastrointestinal bleeding, increased cTn predicts a longer time to diagnosis and treatment, increased length of hospital stay, and increased mortality. cTn increases are diagnostically and prognostically useful in patients with cardiac inflammatory diseases and in patients with respiratory disease; in respiratory disease cTn can help identify patients who would benefit from aggressive management. In chronic renal failure patients the diagnostic sensitivity of cTn for ACS is decreased, but cTn is prognostic for the development of cardiovascular disease. cTn also provides useful information when increases are attributable to various iatrogenic causes and blunt chest trauma.Summary: Information on the diagnostic and prognostic uses of cTn in conditions other than ACS and heart failure is accumulating. Although increased cTn in settings other than ACS or heart failure is frequently considered a clinical confounder, the astute physician must be able to interpret cTn as a dynamic marker of myocardial damage, using clinical acumen to determine the source and significance of any reported cTn increase.

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“…Following operative repair of congenital heart disease [15] , and possibly cardiotoxic chemotherapy [16] , troponins can be used as predictors of subsequent cardiac recovery and mortality. Gene mutations in cardiac troponin I (cTnI) account for up to 5% of genotyped families with familial hypertrophic cardiomyopathy (FHC).…”

Section: Paediatric Application Of Troponinmentioning

confidence: 99%

Serum Troponin in Neonatal Intensive Care

El-Khuffash

Molloy

2007

Neonatology

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Cardiac troponins have a major role in screening and diagnosis of myocardial ischaemia in adults and children. Their introduction has redefined the diagnosis of myocardial infarction in adults and provided valuable prognostic information. In the paediatric population, troponins show a good correlation with the extent of myocardial damage following cardiac surgery and cardiotoxic medication, and can be used as predictors of subsequent cardiac recovery and mortality. This review discusses the current established reference values in term and preterm infants and demonstrates their potential use in neonatology. They may serve as a useful adjunct in the assessment of the magnitude of myocardial injury in respiratory distress syndrome and asphyxia. They may also benefit centres without on-site echocardiography with some evidence showing good correlation with echo-derived markers of myocardial function. The use of troponins in the neonatal unit remains a research tool. More work is needed to explore their prognostic role and monitoring response to treatment following cardioprotective strategies. In preterm infants the effect of inotropes on myocardial function needs further study and troponin may form an integral part of this research.

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Cardiac Troponins in Pediatrics

Cited by 28 publications

References 47 publications

Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance

Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance

Increases of Cardiac Troponin in Conditions other than Acute Coronary Syndrome and Heart Failure

Serum Troponin in Neonatal Intensive Care

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