Cardiac Tumors

Rassl, Doris M.; Davies, S. J.

doi:10.1007/978-1-4471-2407-8_12

Cited by 2 publications

(2 citation statements)

References 66 publications

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“…von Willebrand factor is expressed, but is considered the least sensitive marker for angiosarcoma, especially when the tumor is inadequately differentiated [ 17 , 19 , 20 ]. Meis-Kindblom’s [ 22 ] study found factor VIII monoclonal antibody to be the most sensitive endothelial marker, but Suvarna [ 23 ] states that factor VIII lacks sensitivity and does not stain positive in most cases. Cytokeratin is positive in approximately one-third of angiosarcomas, although most of these cases are epithelial cell type-dominant tumors [ 19 , 22 ].…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Cytokeratin is positive in approximately one-third of angiosarcomas, although most of these cases are epithelial cell type-dominant tumors [ 19 , 22 ]. Cytokeratin shows weak focal staining in angiosarcomas; strongly diffuse staining suggests an alternative diagnosis of mesothelioma or carcinoma [ 23 ]. Vimentin is positive in most endothelial angiosarcomas, but is also positive in other cellular lineages [ 17 , 22 ].…”

Section: Immunohistochemistrymentioning

confidence: 99%

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Primary cardiac angiosarcoma – a review

et al. 2014

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Primary cardiac neoplasms are extremely rare. Angiosarcoma is the most commonly seen histological subtype and is characterized by its permeating and destructive nature. Unfortunately, primary cardiac angiosarcoma is often overlooked as an initial diagnosis because of its rarity. Since the time it was first identified in 1934, little progress has been made in improving survival outcome. Complete or partial surgical resection is still the best option for palliation, with little hope for cure. Improvements have been made in the ability to view and distinguish tumors. Echocardiography is one of the most useful diagnostic tools because of its high sensitivity; therefore, CT and MR images are often used to detect sites of metastatic disease. Immunohistochemistry staining can also be employed as an adjunctive diagnostic tool. CD31, CD34, FLI-1, and von Willebrand factor are the most commonly used markers in detecting tumors of endothelial origin. However, due to the vast heterogeneity within a tumor, immunohistochemistry staining can be quite variable. Surgical resection remains the standard modality of treatment. Primary cardiac angiosarcoma is largely resistant to chemotherapy and/or radiation. However, the exact benefit and its place in a multimodality treatment regimen are still under investigation.

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