Cardiac Valve Involvement in Systemic Diseases: A Review

Grimaldi, Antonio; Vermi, Anna Chiara; Pappalardo, Federico; Brunetti, Natale Daniele; Canna, Giovanni La; Alfieri, Ottavio

doi:10.1002/clc.22099

Cited by 11 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A previous Danish nationwide cohort study reported a roughly three-fold increase in the risk of AS, a four-fold increase in the incidence of AR, and a higher risk of mitral increased relative risk of MR five times in patients with SSc compared to the healthy population [ 5 ]. Increased screening echocardiography might explain this increased prevalence, or it could be due to SSc-specific factors that may contribute to its development.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Systemic Sclerosis

Enabi,

Tahir,

Mukkera

et al. 2023

Cureus

View full text Add to dashboard Cite

Systemic sclerosis (SSc) is a persistent autoimmune disorder. While it commonly impacts the cardiac valves, particularly the mitral valve, involvement of the aortic valve has been seldom documented. We report a case of a 47-year-old male with a history of progressive SSc who displayed complications related to cardiac issues, which were verified through a left atrial appendage biopsy revealing thickening due to fibrosis. This cardiac involvement led to a condition necessitating the replacement of the aortic valve due to aortic regurgitation. This instance underscores the importance of identifying this uncommon association, enabling the delivery of appropriate patient treatment, and reducing complications linked to the underlying condition.

show abstract

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Systemic Sclerosis

Enabi,

Tahir,

Mukkera

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Overall, valvular heart diseases are more common in patients with RA, but they are often mild and asymptomatic [ 3 , 5 , 15 ]. In a follow-up study of patients with mild and moderate aortic valve stenosis, the progression rate to more severe stenosis was not increased in patients with RA when compared to general population [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes of Surgical Aortic Valve Replacement in Patients with Rheumatoid Arthritis

Malmberg

Palomäki

Sipilä

et al. 2021

JCM

View full text Add to dashboard Cite

Patients with rheumatoid arthritis (RA) have increased risk of developing cardiovascular disease and events. Little is, however, known about the influence of RA to the outcomes after surgical aortic valve replacement (SAVR). Methods: In a retrospective, nationwide, multicenter cohort study, RA patients (n = 109) were compared to patients without RA (n = 1090) treated with isolated SAVR for aortic valve stenosis. Propensity score-matching adjustment for baseline features was used to study the outcome differences in a median follow-up of 5.6 years. Results: Patients with RA had higher all-cause mortality (HR 1.76; CI 1.21–2.57; p = 0.003), higher incidence of major adverse cardiovascular events (HR 1.63; CI 1.06–2.49; p = 0.025), and they needed more often coronary artery revascularization for coronary artery disease (HR 3.96; CI 1.21–12.90; p = 0.027) in long-term follow-up after SAVR. As well, cardiovascular mortality rate was higher in patients with RA (35.7% vs. 23.4%, p = 0.023). There was no difference in 30-day mortality (2.8% vs. 1.8%, p = 0.518) or in the need for aortic valve reoperations (3.7% vs. 4.0%, p = 0.532). Conclusions: Patients with rheumatoid arthritis had impaired long-term results and increased cardiovascular mortality after SAVR for aortic valve stenosis. Special attention is needed to improve outcomes of aortic valve stenosis patients with RA after SAVR.

show abstract

“…NBTE depicts a spectrum of sterile lesions from microscopic aggregates of platelets to large vegetations on previously undamaged heart valves in the absence of bacteremia. The most commonly affected valves are the aortic and the mitral [1]. NBTE was previously referred to as marantic endocarditis; "marantic" stems from the Greek word marantikos for "wasting away", signifying the seriousness of conditions associated with NBTE.…”

Section: Diagnosismentioning

confidence: 99%

Non-Bacterial Thrombotic Endocarditis: A Manifestation of Lung Cancer

Venugopal¹

2020

Series Cardiol Res.

View full text Add to dashboard Cite

Non-bacterial thrombotic endocarditis (NBTE) is characterized by vegetations on cardiac valves consisting of fibrin and platelet aggregates that are devoid of inflammation or bacteria. Diagnosis is often challenging and is aided by a high index of suspicion. These factors are reflected by the case of a 53 year old woman with a history of recurrent idiopathic deep vein thrombosis (DVT) prior to presentation at our institution to which she was admitted because of right upper extremity numbness and weakness.

show abstract

Cardiac Valve Involvement in Systemic Diseases: A Review

Cited by 11 publications

References 37 publications

A Rare Presentation of Systemic Sclerosis

A Rare Presentation of Systemic Sclerosis

Long-Term Outcomes of Surgical Aortic Valve Replacement in Patients with Rheumatoid Arthritis

Non-Bacterial Thrombotic Endocarditis: A Manifestation of Lung Cancer

Contact Info

Product

Resources

About