Cardiac ventricular performance in the appropriate‐ for‐gestational age and small‐for‐gestational age fetus: relation to regional cardiac non‐uniformity and peripheral resistance

Цывьян, П. Б.; Malkin, K.; Artemieva, O.; Blyakhman, F. A.; Wladimiroff, J. W.

doi:10.1046/j.1469-0705.2002.00734.x

Cited by 16 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9,21 These data support the hypothesis that in these fetuses, the EI is a more sensitive parameter for the evaluation of diastolic function than Doppler analysis of AV valves.…”

Section: Discussionsupporting

confidence: 71%

Dynamics of the septum primum in fetuses with intrauterine growth restriction

Zielinsky¹,

Beltrame²,

Mânica³

et al. 2009

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

“…9,21 These data support the hypothesis that in these fetuses, the EI is a more sensitive parameter for the evaluation of diastolic function than Doppler analysis of AV valves.…”

Section: Discussionsupporting

confidence: 71%

Dynamics of the septum primum in fetuses with intrauterine growth restriction

Zielinsky¹,

Beltrame²,

Mânica³

et al. 2009

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

“…The subsequent acceleration in cardiac volume and shape, preferencing width for length, has also been previously reported in small for gestation age infants and fetuses undergoing compensatory cardiac growth patterns (Veille et al, 1993;Tsyvian et al, 2002).…”

Section: Normal Versus Compensatory Growthmentioning

confidence: 83%

Growth patterns of the heart and kidney suggest inter-organ collaboration in facultative fetal growth

Lampl

Kuzawa

Jeanty³

2005

Am. J. Hum. Biol.

View full text Add to dashboard Cite

Maternal smoking during pregnancy has been associated with a number of negative sequelae among offspring, including elevated postnatal blood pressure. While animal studies have described organ level alterations with smoke exposure, human data have been more limited. Thirty-four healthy maternal/fetal pairs (24 nonsmokers, 10 smokers) participated in a longitudinal growth study from the thirteenth week of pregnancy to document fetal kidney and heart growth trajectories and morphology. Curve fitting followed by a mixed model for repeated measures identified significantly different growth patterns in kidney width, thickness, length, and volume growth with exposure: the smoke-exposed fetal kidney was wide and thick compared to the unexposed kidney during the second and early third trimester, declining to proportionately thin kidneys for length and width subsequently. Cardiac growth in width and volume followed a reverse pattern: a surge in cardiac volume occurred after 30 weeks with acceleration in cardiac width, resulting in a heart that was wide for length and for fetal weight. Smoke exposure altered fetal growth in size and timing of the heart and kidneys during midgestation, with changes in organ morphology suggesting compensatory growth. These are the first data providing anatomical evidence of altered renal/cardiac volume relationships that may provide a mechanism to previously reported sequelae of in utero smoke exposure. They suggest that cell-level adaptive responses to hypoxia and/or chemical insults are operative and illustrate the importance of longitudinal ultrasound to directly assess the organ-level growth response of the human fetus to a prenatal stress, in lieu of relying on birth outcome measures.

show abstract

“…This finding could be related to a successful fetal adaptive response to raised placental impedance (23) ("brain sparing effect") (24), which is associated with the presence of dramatically different hemodynamic conditions in the vascular regions, supplied by the two ventricles (reduced cerebral resistances for the left ventricle and increased splachnic and placental resistances for the right ventricle) (25). Eventually, this circulatory redistribution is known to lead to ventricular remodelling, due to pressure and volume overload (26) and expectedly to increased NT-proBNP production. However, the fetuses in our study, up to their delivery, did not deteriorate enough to show these cardiac modifications, thus reduction in ventricular wall stress, secondary to reduced cerebral resistances (23), may account for their lower NT-proBNP levels.…”

Section: Discussionmentioning

confidence: 94%