Cardio-Ankle Vascular Index and Ankle Pulse Wave Velocity as a Marker of Arterial Fibrosis in Kidney Failure Treated by Hemodialysis

Ichihara, Atsuhiro; Yamashita, Norimasa; Takemitsu, Tomoko; Kaneshiro, Yuki; Sakoda, Mariyo; Kurauchi-Mito, Asako; Itoh, Hiroshi

doi:10.1053/j.ajkd.2008.06.007

Cited by 38 publications

(46 citation statements)

References 14 publications

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“…Several reports have shown the usefulness of CAVI for the detection of atherosclerotic diseases 10,21) . Ichihara et al reported that CAVI reflects histological arterial fibrosis in hemodialysis patients and is a useful clinical marker for evaluating arterial stiffness in patients with kidney failure treated by hemodialysis 22) ; however, there are no reports on the correlation between CAVI and eGFR in community residents and, to the best of our knowledge, this is the first report demonstrating that CAVI negatively correlates independently with eGFR in the general population.…”

Section: Discussionmentioning

confidence: 86%

Association between Arterial Stiffness and Estimated Glomerular Filtration Rate in the Japanese General Population

Kubozono

Miyata

Ueyama

et al. 2009

JAT

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Aim: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, although it has yet to be established whether CKD is an independent risk factor for arterial stiffness in community residents. The purpose of this study was to determine the correlation between the cardio-ankle vascular index (CAVI) and estimated glomerular filtration rate (eGFR) in the general population. Methods: We studied 881 consecutively enrolled subjects undergoing health checkups. CAVI was calculated automatically from the pulse volume record, blood pressure and the vascular length from the heart to the ankle. CKD was evaluated by the eGFR. . It has been reported that microalbuminuria is a strong determinant of ischemic heart disease and death, independent of age, sex, hypertension, diabetes mellitus, renal function and the plasma lipid profile 6) . As a consequence, mild renal dysfunction has recently attracted increased attention, with a reduction in the estimated glomerular filtration rate (eGFR) being regarded as a useful index of kidney damage and also an effective strategy for detecting patients with CKD 7). Recently, an atherosclerotic index, the cardioankle vascular index (CAVI), has been developed that involves measuring pulse wave velocity (PWV) and blood pressure (BP). CAVI is adjusted for BP based on the stiffness parameter and is expressed as arterial stiffness independent of BP 8, 9) . We have reported previously that CAVI showed a weaker correlation IntroductionChronic kidney disease (CKD) is a worldwide public health problem 1) . Cardiovascular disease (CVD) is associated frequently with CKD, a relationship that is important given that individuals with CKD are more likely to die of CVD than to develop kidney failure 2) . Numerous studies have established that CKD is a major risk factor for CVD, not only in populations at high risk for CVD, but also in the general

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Section: Discussionmentioning

confidence: 86%

Association between Arterial Stiffness and Estimated Glomerular Filtration Rate in the Japanese General Population

Kubozono

Miyata

Ueyama

et al. 2009

JAT

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“…Here, is CAVI or PWV a good marker reflecting arteriosclerosis in CKD patients ? Recent reports showed that CAVI was loosely more cassociated with carotid and coronary atherosclerosis than brachial-ankle PWV (BaPWV), providing a more convenient method in Japan 32) , and that CAVI reflected histological arterial fibrosis better than PWV in patients with ESRD 33) . CAVI is independent of blood pressure, but PWV is affected by blood pressure 15) ; therefore, although both CAVI and PWV are parameters for evaluating arterial stiffness, CAVI may be superior to BaPWV as a parameter of arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

Association between Cardio-Ankle Vascular Index and Serum Cystatin C Levels in Patients with Cardiovascular Risk Factor

Nakamura

Iizuka

Takahashi

et al. 2009

JAT

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“…Ichihara et al 34) showed that CAVI was higher in patients with kidney failure and reported a correlation between the severity of arterial fibrosis and CAVI. Shen et al 35) used CAVI to predict the risk of de novo arterial stiffness in patients on chronic dialysis.…”

Section: B Chronic Kidney Disease and Hemodialysis Patientsmentioning

confidence: 99%

Cardio-Ankle Vascular Index (CAVI) as a Novel Indicator of Arterial Stiffness: Theory, Evidence and Perspectives

Shirai

Hiruta

Song

et al. 2011

J Atheroscler Thromb

404

426

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The cardio-ankle vascular index (CAVI) is a new index of the overall stiffness of the artery from the origin of the aorta to the ankle. The most conspicuous feature of CAVI is its independence of blood pressure at the time of measurement. CAVI increases with age and in many arteriosclerotic diseases, such as coronary artery disease, carotid arteriosclerosis, chronic kidney disease and cerebrovascular disease, and is related to many coronary risk factors, such as hypertension, diabetes mellitus, dyslipidemia and smoking. Furthermore, CAVI decreases by controlling diabetes mellitus and hypertension, and also by abstaining from smoking. This suggests that CAVI is a physiological surrogate marker of athero-or arteriosclerosis, and also might be an indicator of lifestyle modification. Recently, it has been reported that CAVI and several left ventricular functions are co-related, suggesting a connection between the heart muscle and vascular function. This review covers the principles of CAVI and our current knowledge about CAVI, focusing on its roles and future outlook. J Atheroscler Thromb, 2011; 18:924-938.

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Cardio-Ankle Vascular Index and Ankle Pulse Wave Velocity as a Marker of Arterial Fibrosis in Kidney Failure Treated by Hemodialysis

Cited by 38 publications

References 14 publications

Association between Arterial Stiffness and Estimated Glomerular Filtration Rate in the Japanese General Population

Association between Arterial Stiffness and Estimated Glomerular Filtration Rate in the Japanese General Population

Association between Cardio-Ankle Vascular Index and Serum Cystatin C Levels in Patients with Cardiovascular Risk Factor

Cardio-Ankle Vascular Index (CAVI) as a Novel Indicator of Arterial Stiffness: Theory, Evidence and Perspectives

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