Cardio-Ankle Vascular Index Is Superior to Brachial-Ankle Pulse Wave Velocity as an Index of Arterial Stiffness

Takaki, Akira; Ogawa, Hiroshi; Wakeyama, Takatoshi; Iwami, Takahiro; Kimura, Masayasu; Hadano, Yasuyuki; Matsuda, Susumu; Miyazaki, Yousuke; Hiratsuka, Atsushi; Matsuzaki, Masunori

doi:10.1291/hypres.31.1347

Cited by 156 publications

(145 citation statements)

References 23 publications

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“…However, that study was performed by measuring carotid-femoral pulse wave velocity, which though noninvasive requires a complicated technique. Our data demonstrated similar results using CAVI, which has been recently established as a marker of arterial stiffness and is widely used in clinical settings (Kubozono et al 2007;Takaki et al 2007;Kadota et al 2008;Takaki et al 2008). Mizuguchi et al (2007) demonstrated that CAVI was more closely related to the LV diastolic functional parameter (early diastolic strain rate) obtained from tissue Doppler echocardiography than that obtained from conventional Doppler echocardiography, and concluded that arterial stiffness was associated with LV relaxation during early diastole.…”

Section: Discussionsupporting

confidence: 82%

“…Previous studies (Masugata et al 2005;Mizuguchi et al 2007;Sakane et al 2008;Takaki et al 2008) have shown the association between LV diastolic function by echocardiography and arterial stiffness by CAVI or pulse wave velocity. A previous study by Tsioufis et al (2005) already proved the superiority of tissue Doppler echocardiography over the conventional Doppler echocardiography for assessing arterial mechanics.…”

Section: Discussionmentioning

confidence: 92%

“…First, we had no data regarding coronary atherosclerosis assessed by coronary angiography. Although it is well known that CAVI is influenced by aging (Nakamura et al 2008;Takaki et al 2008), normal values of CAVI in various age strata have not been fully established. Thus, in the present study, we used the cut-off level for the detection of coronary stenoses (CAVI ≥ 8.81) reported by Nakamura et al (2008) to discriminate patients with abnormal CAVI from those with normal CAVI.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it seems that LV diastolic function may be associated with arterial stiffness. Although several previous studies have shown an association between LV diastolic function and arterial stiffness (Masugata et al 2005;Takaki et al 2008), these studies were performed using conventional Doppler echocardiography, which measures blood flow velocities in cardiac cavity.…”

mentioning

confidence: 99%

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Tissue Doppler Echocardiography for Predicting Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Masugata

Senda

Goda

et al. 2009

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Tissue Doppler Echocardiography for Predicting Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Masugata

Senda

Goda

et al. 2009

Tohoku J. Exp. Med.

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“…We hypothesize that CBP may reflect cardiac structure and function better than peripheral blood pressure and that it may show a better correlation with cardiac function compared with the cardio-ankle vascular index (CAVI), which has been an established marker of arterial stiffness from the aortic valve to the ankle. [10][11][12] In this study, we examined the associations between CBP and cardiac structure and function by comparing them with those of arterial stiffness assessed by CAVI in treated hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients

et al. 2009

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Recent automated applanation tonometry can measure radial pulse wave-derived central blood pressure (CBP), which has shown a prognostic value independently of peripheral blood pressure. However, CBP's clinical significance has not been fully established. We examined the associations between CBP and cardiac structure and function by comparing them with those of arterial stiffness assessed by cardio-ankle vascular index (CAVI) in treated hypertensive patients. Enrolled in the study were 102 patients (71 ± 7 years) with treated hypertension. The transmitral early-to-atrial velocity ratio (E/A), peak systolic (S¢), early diastolic (E¢) mitral annular velocities and the Tei index were measured as indexes of cardiac function derived from conventional and tissue Doppler echocardiography. Left ventricular mass index (LVMI) was measured as an index of LV hypertrophy. CBP and CAVI were measured just after echocardiographic examination. CBP, but not CAVI, correlated with LVMI (r¼0.306, Po0.01). Although CBP correlated only with the Tei index (r¼0.201, Po0.05), CAVI correlated with E/A (r¼À0.387, Po0.001), S¢ (r¼À0.270, Po0.01), E¢ (r¼À0.362, Po0.01) and the Tei index (r¼0.339, Po0.01). Stepwise regression analysis revealed that neither CBP nor CAVI was independently associated with E/A, S¢ or E¢. However, CAVI, but not CBP, was independently associated with the Tei index (b coefficient¼0.311, Po0.001), reflecting both LV systolic and diastolic function. In conclusion, CBP may be suitable for detecting LV hypertrophy. In contrast, CAVI may be suitable for detecting LV dysfunction. This difference, suggesting the clinical value of each parameter, should be kept in mind when we use CBP and CAVI for assessing arteriosclerosis in treated hypertension.

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Tofacitinib improves atherosclerosis despite up-regulating serum cholesterol in patients with active rheumatoid arthritis: a cohort study

Kume¹,

Amano²,

Yamada³

et al. 2017

Rheumatol Int

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Patients with rheumatoid arthritis (RA) have an increased cardiovascular (CV) risk. This study aimed to analyze the effects of Tofacitinib treatment, a Janus kinase inhibitor, on atherosclerosis in patients with RA. Patients with an active RA (28-joint disease activity score-erythrocyte sedimentation rate > 3.2) despite methotrexate (MTX) treatment 12 mg/week were included in this open-label prospective study and started on Tofacitinib (10 mg/day, 5 mg twice/day). Japanese guideline does not allow high dose of MTX. All patients used a stable dosage of MTX, steroids, and statins or lipid-lowering drugs. The primary endpoint was the comparison of the carotid intima-media thickness (CIMT) at the baseline and 54 weeks after Tofa treatment. Clinical data were collected at regular visits. Forty-six patients completed this study. CIMT did not significantly change from baseline to 54 weeks (1.09 ± 0.69 and 1.08 ± 0.78 mm, p = 0.82). In 12 patients who had atherosclerosis at baseline (carotid intima-media thickness > 1.10 mm), there was a significant decrease in CIMT (0.05± 0.026 mm; p < 0.05). However, the decrease in CIMT was of limited clinical significance. Tofacitinib increased fasting total cholesterol levels from baseline to 54 weeks (216 ± 25.3 and 234 ± 28.8 mg/dL, p < 0.01). Tofacitinib affects atherosclerosis in patients with active RA The CIMT in RA patients was stable. Tofacitinib decreased the CIMT of patients who had increased CIMT at baseline. Tofacitinib reduced RA disease activity and limited vascular damage despite up-regulating cholesterol in patients with an active RA.

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Cardio-Ankle Vascular Index Is Superior to Brachial-Ankle Pulse Wave Velocity as an Index of Arterial Stiffness

Cited by 156 publications

References 23 publications

Tissue Doppler Echocardiography for Predicting Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Tissue Doppler Echocardiography for Predicting Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients

Tofacitinib improves atherosclerosis despite up-regulating serum cholesterol in patients with active rheumatoid arthritis: a cohort study

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