Cardio-metabolic disease in India—the up-coming tsunami

Jadhav, Uday

doi:10.21037/atm.2018.06.47

Cited by 9 publications

(3 citation statements)

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“…Cardiovascular diseases (CVD) are the leading cause of death and disability in the world. 1 , 2 It was responsible for 31.8% of all deaths and 14.7% of Disability Adjusted Life Years (DALYs) globally in the year 2017. 2 According to the findings of the Global Burden of Disease (GBD) study group, globally, there were an estimated 422 million prevalent cases of CVD in 2015, the largest contributor being the South Asian region.…”

Section: Introductionmentioning

confidence: 99%

The burgeoning cardiovascular disease epidemic in Indians – perspectives on contextual factors and potential solutions

Kalra¹,

Jose²,

Prabhakaran³

et al. 2023

The Lancet Regional Health - Southeast Asia

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Section: Introductionmentioning

confidence: 99%

The burgeoning cardiovascular disease epidemic in Indians – perspectives on contextual factors and potential solutions

Kalra¹,

Jose²,

Prabhakaran³

et al. 2023

The Lancet Regional Health - Southeast Asia

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“…Indians appear to have a unique "South Asian phenotype" with high propensity for metabolic syndrome, insulin resistance, greater degree of central obesity as well as a high prevalence of hypertension at relatively young ages. 6 In addition, there appears to be suboptimal management of cardio-This article is protected by copyright. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Function and Cardiometabolic‐Inflammatory Risk Factors Among Older Indians and Americans

Lee

Beaumaster

et al. 2020

J American Geriatrics Society

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OBJECTIVES: To investigate how cardio-metabolic-inflammatory risk factors are related to cognition among older adults in India and the United States. DESIGN: The Longitudinal Aging Study in India -Diagnostic Assessment of Dementia (LASI-DAD) and the Harmonized Cognitive Assessment Protocol of the Health and Retirement Study (HRS-HCAP) in the United States conducted an in-depth assessment of cognition, using protocols designed for international comparison. SETTING: Cognitive tests were conducted in hospital or household settings in India and in household settings in the United States. PARTICIPANTS: Respondents aged 60 and older from LASI-DAD (N=1,865) and respondents aged 65 and older from HRS-HCAP (N=2,111) who provided venous blood specimen. MEASUREMENTS:We used total composite scores from the common cognitive tests administered. Cardiovascular risk was indicated by systolic and diastolic blood pressure, pulse rate, pro-B-type-natriuretic-peptide (proBNP), and homocysteine. Metabolic risk was measured by body mass index, glycosylated hemoglobin (HbA1c), HDL-cholesterol, and lipoprotein (a) (only in India). Inflammatory risk was indicted by white blood cell count, C-reactive protein, albumin, and uric acid (only in India). RESULTS:The distribution of both total cognition scores and of cardio-metabolic risk factors differed significantly between India and the United States. In both countries, lower cognition was associated with older age, lower education, elevated homocysteine, elevated proBNP, and lower This article is protected by copyright. All rights reserved. albumin levels. The associations between HbA1c levels and cognitive measures were statistically significant in both countries, but in the opposite direction, with a coefficient of 1.5 (p<0.001) in India and -2.4 (p<0.001) in the United States for one percentage increase in absolute HbA1c value.CONCLUSION: Cardio-metabolic-inflammatory biomarkers are associated with cognitive functional levels in each country, but the relationships may vary across countries.

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“…Unfortunately, CVD has now become the leading cause of death in India and the global burden of cardiometabolic diseases is expected to increase, with individuals of lower socioeconomic backgrounds often having less than optimal therapy and consequently, poorer outcomes. Uday M. Jadhav describes an upcoming tsunami, not dissimilar to the disaster after the Indian Ocean earthquake in 2004 (7). In a country of 1.3 billion people, he describes a unique "atherogenic dyslipidemic profile" and a "South Asian phenotype", with high propensity for metabolic syndrome.…”

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confidence: 99%

Global perspectives on cardiometabolic risk and cardiovascular disease: from basic science to bedside

Ferdinand¹

2018

Ann. Transl. Med.

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As guest editor of this special issue of the Annals of Translational Medicine (ATM), I am pleased to present the work from invited authors who offer international perspectives on critically important topics related to cardiometabolic risk and cardiovascular disease (CVD). The World Health Organization (WHO) has estimated that CVD is the number one cause of mortality globally, with more people dying annually from CVD than from any other cause (1). With as many as 17.7 million people dying from CVD in 2015, CVD represents 31% of all deaths worldwide (1). Moreover, over three quarters CVD deaths occur in low and middle-income countries, highlighting that this problem is not unique to industrialized nations (1). Accordingly, this special issue of the ATM provides perspectives on CVD not only in the United States (US), but also worldwide. We present a global, comprehensive view of innovative research, reviews, editorials and perspectives from basic science at the bench level to clinic interventions and public health considerations. While this edition of ATM builds on much of the research and clinical care conducted at

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Cardio-metabolic disease in India—the up-coming tsunami

Cited by 9 publications

References 10 publications

The burgeoning cardiovascular disease epidemic in Indians – perspectives on contextual factors and potential solutions

The burgeoning cardiovascular disease epidemic in Indians – perspectives on contextual factors and potential solutions

Cognitive Function and Cardiometabolic‐Inflammatory Risk Factors Among Older Indians and Americans

Global perspectives on cardiometabolic risk and cardiovascular disease: from basic science to bedside

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