Cardio-metabolic risk factors in Tunisia: state of the art

Kéchida, M.

doi:10.1007/s11739-019-02164-7

Cited by 2 publications

(2 citation statements)

References 51 publications

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“…The prevalence of cardio-metabolic diseases, including diabetes mellitus, dyslipidemia, and hypertension is currently increasing and represents a significant health problem in Tunisia [1][2][3][4]. It is well known that diabetes mellitus combined with the myriad of cardiovascular factors is responsible for the development of long-term microvascular and macrovascular complications, which contribute to the increased risk of morbidity and mortality [4,5].…”

Section: Introductionmentioning

confidence: 99%

Increased skin autofluorescence of advanced glycation end products (AGEs) in subjects with cardiovascular risk factors

Sakly

Wolffenbuttel

Khochtali

et al. 2022

Int J Diabetes Dev Ctries

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Background As a clinical and non-invasive tool, the AGE Reader measures skin autofluorescence (SAF) to estimate the accumulation of advanced glycation end products (AGEs) in the skin. Accumulation of AGEs has been implicated in several inflammation-associated diseases, including diabetes and cardio-metabolic diseases. This study aimed to assess SAF in subjects with and without cardiovascular risk (CVR) factors and examine the association between SAF and various bio-clinical parameters. Methods In a cross-sectional study, we included 250 participants between 19 and 86 years of age divided into two groups: a healthy group (n = 88) and subjects with CVR factors (n = 162 in total, diabetes n = 48, hypertension n = 62, and both n = 52). We assessed skin AGE measures and biological and clinical data.Results SAF was significantly higher in subjects with CVR factors than in healthy participants (2.42 ± 0.38 vs 1.90 ± 0.29 respectively; p < 0.001). SAF was associated with age, gender, BMI, duration of diabetes, HbA1c, triglyceride, and obesity. Multivariate analysis showed that age and duration of diabetes were the independent determinants of SAF. The ROC analysis indicated that a SAF > 2.25 AU was the optimal cut-off point to predict the presence of diabetes and/or hypertension and dyslipidemia (p < 0.001). Conclusion This Tunisian population-based study shows an increased SAF level in subjects with diabetes and/or hypertension and dyslipidemia compared to healthy subjects. The AGE Reader device is a rapid and non-invasive tool in clinical practice to evaluate and screen CVR factors in Tunisia with a North African phototype.

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Section: Introductionmentioning

confidence: 99%

Increased skin autofluorescence of advanced glycation end products (AGEs) in subjects with cardiovascular risk factors

Sakly

Wolffenbuttel

Khochtali

et al. 2022

Int J Diabetes Dev Ctries

View full text Add to dashboard Cite

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“…The numbers of subjects suffering for metabolic disorders are constantly increasing in Tunisia [3][4][5]. Type 2 diabetes, a silent disease, induces long-term vascular complications and is diagnosed too late [6,7]. Diabetic patients which are under treatment do not prevent to develop microvascular complications (retinopathy, nephropathy and neuropathy) and macrovascular complications (cerebrovascular disease, cardiovascular disease and peripheral vascular disease) which that contribute to the increased risk of morbidity and mortality [8].…”

Section: Introductionmentioning

confidence: 99%

Skin Autofluorescence Profile in Tunisian Subjects with and Without Metabolic Disorders

Khochtali

Bouida

Boubaker

et al. 2021

Preprint

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Background: The AGE Reader, as a clinical tool for non invasive assessment, measures the accumulation of advanced glycation end products (AGEs) in skin tissues shown as skin autofluorescence (SAF). AGEs Accumulation has been implicated in several diseases. There is no data about SAF profile in Tunisian population, this study aimed to assess firstly SAF profile in subjects with and without metabolic disorders and secondly to examine the association between SAF and various clinical parameters.Methods: In a cross-sectional study, we included 220 participants between 19 and 86 years of age who were subdivided in two groups: a healthy group (n=93) and patients group with metabolic disorders (n=127) contains three subgroups as following: diabetic patients (n=32), hypertensive patients (n=54) and patients with both diabetes and hypertension (n=41). Skin AGEs accumulation was measured by AGE Reader and clinical data was obtained.Results: SAF was significantly higher in patients group compared to healthy group [2.40 AU (2.10-2.60) vs. 2.00 AU (1.70-2.10) respectively; P <0.001]. Diabetic patients and hypertensive patients showed an increased level of SAF. The highest of SAF was observed in patient with both coexistence of diabetes, hypertension and dyslipidemia. SAF was associated with age, gender, BMI, duration of diabetes, HbA1c, triglyceride and obesity. Multivariate analysis showed that age and duration of diabetes were independent determinant of SAF. The ROC analysis indicated that an SAF > 2.25 AU was optimal cut-off point to predict the presence of metabolic disorders (P <0.001). Conclusion: SAF was increased in patients with diabetes and/or with hypertension and dyslipidemia. AGE Reader device is a rapid and helpful tool in clinical practice for evaluating and screening metabolic disorders in undiagnosed subjects.

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Cardio-metabolic risk factors in Tunisia: state of the art

Cited by 2 publications

References 51 publications

Increased skin autofluorescence of advanced glycation end products (AGEs) in subjects with cardiovascular risk factors

Increased skin autofluorescence of advanced glycation end products (AGEs) in subjects with cardiovascular risk factors

Skin Autofluorescence Profile in Tunisian Subjects with and Without Metabolic Disorders

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