Cardio-oncology: Implications for Clinical Practice for Women

Kassaian, Seyed Ebrahim; Gandhi, Bhumika; Barac, Ana

doi:10.1007/s11886-022-01779-1

Cited by 3 publications

(1 citation statement)

References 96 publications

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“…I believe a holistic, longitudinal approach to women’s health is needed—one that considers the sex- and gender-specific risk factors and the biological changes throughout their lives. This approach has been shown to improve the quality of care for women and their overall experience and outcomes in cancer, primary, and cardiac care ( 1 , 10 , 11 ).…”

mentioning

confidence: 99%

Multidisciplinary care for women with aortic disease: the way to improve disparities

Afifi

2023

Ann Cardiothorac Surg

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mentioning

confidence: 99%

Multidisciplinary care for women with aortic disease: the way to improve disparities

Afifi

2023

Ann Cardiothorac Surg

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Women’s cardiovascular health – the cardio-oncologic jigsaw

Ray,

Butel-Simoes,

Lombard

et al. 2023

Climacteric

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Cardiovascular Mortality in Patients with Gynecological Cancers: A Population-based Cohort Study

Yang,

et al. 2024

Preprint

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Objective The survival rate of gynecological cancers (GCs) has improved significantly in recent decades. Patients with GCs did not necessarily succumb to the primary cancer. Cardiovascular health might be a critical determinant of long-term survival. This study aimed to investigate the mortality rate and risk factors associated with cardiovascular disease (CVD) death in patients with GCs. Methods A total of 399,399 cases of GCs diagnosed between 2000 and 2020 from the Surveillance, Epidemiology, and End Results (SEER) database were included in this study. The standardized mortality ratio (SMR) for CVD mortality was estimated. Prognostic factors for CVD death were assessed using cause-specific hazard ratios with 95% confidence intervals within a competing risk model, considering non-cardiovascular death as a competing risk. Results Of the 399,399 patients with GCs, 117,551 (29%) died from GCs, and 16,371 (4.1%) died from CVD. Of the CVD deaths, 73.2% were attributed to heart disease. The SMR of CVD mortality was highest in survivors diagnosed before age 45 years, and the risk of CVD mortality remained elevated throughout the follow-up period compared to the general United States (US) population. In recent years, the SMRs for CVD mortality risk increased steadily in all subtypes of GCs, except for vulvar cancer. Older age, black race, localized stage, unmarried/single/divorced, vaginal and vulvar cancers, and radiation therapy were associated with a higher risk of CVD mortality. A nomogram was developed and validated using these variables to predict CVD death risk in patients with GCs. Conclusions The risk of CVD mortality in patients with GCs was increased and was significantly higher compared with the general US population. A nomogram was constructed and validated to forecast the risk of CVD mortality in individuals with GCs. More attention should be paid to cardiovascular health during diagnosis to improve survival rates.

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Cardio-oncology: Implications for Clinical Practice for Women

Cited by 3 publications

References 96 publications

Multidisciplinary care for women with aortic disease: the way to improve disparities

Multidisciplinary care for women with aortic disease: the way to improve disparities

Women’s cardiovascular health – the cardio-oncologic jigsaw

Cardiovascular Mortality in Patients with Gynecological Cancers: A Population-based Cohort Study

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