Cardio-oncology: Understanding the different mechanisms of cardiovascular toxicity

Toste, Júlia

doi:10.1016/j.repc.2021.04.011

Cited by 1 publication

(2 citation statements)

References 21 publications

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“…Interstitial fibrosis cause subsequent diastolic dysfunction left ventricular dysfunction, or left ventricular remodeling, and fibrosis of the conduction system may provoke arrhythmias or conduction defects. Pericardial fibrosis is important for many pericardial syndromes [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

“…There are many risk factors deteriorating cardiotoxic effects of radiotherapy, such as cumulative radiation dose, irradiated heart volume, young age at the time of radiation exposure (especially doses >30–50 Gy), fractional dosage (>2 Gy), heart volume irradiated, young patient age at the time of radiation exposure, the time elapsed since exposure, concomitant use of other chemotherapeutic agents and classical cardiovascular risk factors presentation [ 11 ]. Multiple factors, including cellular composition, differentiation, cell replication capacity, and cellular radiation sensitivity, determine the extent of possible toxicities [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Siaravas

Katsouras

Sioka

2023

IJMS

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Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment. There are many mechanisms of radiation treatment exposure to toxicities. Our aim was to summarize the literature about known mechanisms of radiation-induced cardiac toxicities. We performed a systematic review of the literature on the PubMed database until October 2022 about cardiovascular toxicities and radiation therapy exposure. Only systematic reviews, meta-analyses, and reviews were selected. Out of 1429 publications screened, 43 papers met inclusion criteria and were selected for the umbrella review process. Microvascular and macrovascular complications could lead to adverse cardiac effects. Many radiotherapy-associated risk factors were responsible, such as the site of radiation treatment, beam proximity to heart tissues, total dosage, the number of radiotherapy sessions, adjuvant chemotherapeutic agents used, and patient traditional cardiovascular risk factors, patient age, and gender. Moreover, important dosage cutoff values could increase the incidence of cardiac toxicities. Finally, the time from radiation exposure to cardiac side effects was assessed. Our report highlighted mechanisms, radiation dosage values, and the timeline of cardiovascular toxicities after radiation therapy. All of the above may be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%