Cardio-protective role of terazosin is possibly mediated through alteration in thyroid function

Jatwa, Rameshwar; Kar, Anand

doi:10.1016/j.ejphar.2006.08.074

Cited by 16 publications

(30 citation statements)

References 23 publications

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“…Radioimmunoassay of insulin and thyroid hormones. Total circulating insulin, T 3 and T 4 were estimated by radioimmunoassay in serum samples following the specific protocols provided in the kits as routinely done in our laboratory [6–9].…”

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confidence: 99%

“…[10] using bovine serum albumin as standard. Serum glucose concentration was measured by glucose oxidase method of Trinder [11], where 4‐aminoantipyrine and phenol react with glucose to yield a red coloured complex, as done previously in our laboratory [4,6–8]. Lipid peroxidation was evaluated in kidney and heart tissues by the reaction of thiobarbituiric acid with malondialdehyde [4,6–9,12].…”

mentioning

confidence: 99%

“…Serum glucose concentration was measured by glucose oxidase method of Trinder [11], where 4‐aminoantipyrine and phenol react with glucose to yield a red coloured complex, as done previously in our laboratory [4,6–8]. Lipid peroxidation was evaluated in kidney and heart tissues by the reaction of thiobarbituiric acid with malondialdehyde [4,6–9,12]. Tissue GSH content and activity of superoxide dismutase were determined using Ellman's reagent [13] and pyrogallol autoxidation inhibition assay [14], respectively.…”

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confidence: 99%

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Amelioration of Corticosteroid‐Induced Type 2 Diabetes Mellitus by Rosiglitazone Is Possibly Mediated through Stimulation of Thyroid Function and Inhibition of Tissue Lipid Peroxidation in Mice

Jatwa

Parmar

Panda

et al. 2007

Basic Clin Pharma Tox

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Abstract:We investigated the possible involvement of thyroid hormones and lipid peroxidation in the antidiabetic potential of rosiglitazone (a peroxisome proliferator-activated receptors γ -agonist) on corticosteroid-induced type 2 diabetes mellitus. Rosiglitazone was administered to dexamethasone-induced hyperglycaemic male mice and the alterations in serum concentrations of thyroid hormones insulin, total cholesterol, triglycerides and fasting glucose were studied. Simultaneously changes in lipid peroxidation, reduced glutathione (GSH) content, superoxide dismutase and catalase activities in renal and cardiac tissues (which are commonly affected in diabetes mellitus), were also investigated. Administration of dexamethasone (1.0 mg /kg /day intramuscularly for 28 days) caused hyperglycaemia with a parallel increase in serum insulin, total cholesterol, triglycerides and tissue lipid peroxidation with a decrease in serum levels of both the thyroid hormones (triiodothyronine, T 3 and thyroxine, T 4 ) and in the activity of associated tissue antioxidants such as superoxide, catalase and glutathione. However, rosiglitazone administration (3.2 mg /kg /day orally for 21 days) along with an equivalent amount of dexamethasone reverted most of these changes, including a marked inhibition of tissue lipid peroxidation and an increase in the serum levels of both thyroid hormones. The present findings reveal that the test drug ameliorates corticosteroid-induced type 2 diabetes mellitus through an increase in serum thyroid hormone concentrations and inhibition in tissue lipid peroxidation.

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Amelioration of Corticosteroid‐Induced Type 2 Diabetes Mellitus by Rosiglitazone Is Possibly Mediated through Stimulation of Thyroid Function and Inhibition of Tissue Lipid Peroxidation in Mice

Jatwa

Parmar

Panda

et al. 2007

Basic Clin Pharma Tox

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“…For the estimation of fasting serum glucose concentration, glucose oxidase/peroxidase method of Trinder [29] was followed, where 4‐aminoantipyrine and phenol react with glucose to yield a red colored complex as routinely performed in our laboratory [14–18]. While for the estimation of serum TC and HDL‐C, spectrometric method of Allain et al.…”

Section: Methodsmentioning

confidence: 99%

Anti‐inflammatory and anti‐peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation

Jatwa

Kar

2009

Fundamemntal Clinical Pharma

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This study was designed to reveal the possible involvement of thyroid hormones, if any, in diacerein induced alterations in glucose metabolism and tissue lipid peroxidation (LPO) in the animal model of carrageenan-induced inflammation. We studied the influence of diacerein administration on the changes in carrageenan-induced thyroid dysfunction; hepatic, renal and cardiac LPO as well as serum glucose, thyroid hormones and insulin concentrations in Wistar rats. Alterations in paw volume, serum levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol and triglycerides as well as hepatic, renal and cardiac reduced glutathione (GSH) contents were also studied as supporting parameters. While a decrease in the level of serum thyroid hormones and HDL-C and in tissue GSH content was observed in carrageenan-treated animals, it increased paw volume, the concentration of other serum lipids, glucose and insulin as well as tissue LPO. However, following diacerein administration for 21 days to carrageenan-treated animals, level of thyroid hormones and all other thyroid dependent parameters were reversed suggesting that the drug might be acting through stimulation in the thyroid functions.

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“…Total circulating T 3 , T 4 and insulin were estimated by radioimmunoassay in serum samples following the protocols provided in the kits, as routinely done in our laboratory (Jatwa & Kar, 2006b; Panda & Kar, 2007a, 2007b. In brief, RIA was performed using trishydroxy methyl amino methane buffer (0.14 M, containing 0.1% gelatin; pH 8.6).…”

Section: Estimation Of Serum T 3 T 4 and Insulin Levelsmentioning

confidence: 99%

Soy sterols in the regulation of thyroid functions, glucose homeostasis and hepatic lipid peroxidation in mice

Panda¹,

Kar²,

Patil³

2009

Food Research International

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Cardio-protective role of terazosin is possibly mediated through alteration in thyroid function

Cited by 16 publications

References 23 publications

Amelioration of Corticosteroid‐Induced Type 2 Diabetes Mellitus by Rosiglitazone Is Possibly Mediated through Stimulation of Thyroid Function and Inhibition of Tissue Lipid Peroxidation in Mice

Amelioration of Corticosteroid‐Induced Type 2 Diabetes Mellitus by Rosiglitazone Is Possibly Mediated through Stimulation of Thyroid Function and Inhibition of Tissue Lipid Peroxidation in Mice

Anti‐inflammatory and anti‐peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation

Soy sterols in the regulation of thyroid functions, glucose homeostasis and hepatic lipid peroxidation in mice

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