Cardio-pulmonary MRI for detection of treatment response after a single BPA treatment session in CTEPH patients

Schoenfeld, Christian; Hinrichs, Jan B.; Olsson, Karen M.; Kuettner, Martin-Alexander; Renne, Julius; Kaireit, Till F.; Czerner, Christoph; Wacker, Frank; Hoeper, Marius M.; Meyer, Bernhard; Vogel‐Claussen, Jens

doi:10.1007/s00330-018-5696-4

Cited by 31 publications

(24 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MRI has been proposed and continuously validated as perioperative monitoring tool for CTEPH [ 7 , 8 , 10 , 18 , 22 ]. Inter- and intraobserver variance has been reported previously [ 10 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Perioperative CTEPH patient monitoring with 2D phase-contrast MRI reflects clinical, cardiac and pulmonary perfusion changes after pulmonary endarterectomy

et al. 2020

Self Cite

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is an emerging tool for diagnosis and treatment monitoring of chronic thromboembolic pulmonary hypertension (CTEPH). The current study aims to identify central pulmonary arterial hemodynamic parameters that reflect clinical, cardiac and pulmonary changes after PEA. 31 CTEPH patients, who underwent PEA and received pre- and postoperative MRI, were analyzed retrospectively. Central pulmonary arterial blood flow, lung perfusion and right heart function data were derived from MRI. Mean pulmonary arterial pressure (mPAP) and 5-month follow-up six-minute walk-distance (6MWD) were assessed. After PEA, mPAP decreased significantly and patients achieved a higher 6MWD. Central pulmonary arterial blood flow velocities, pulmonary blood flow (PBF) and right ventricular function increased significantly. Two-dimensional (2D) phase-contrast (PC) MRI-derived average mean velocity, maximum mean velocity and deceleration volume changes after PEA correlated with changes of 6MWD and right heart ejection fraction (RVEF). Deceleration volume is a novel 2D PC MRI parameter showing further correlation with PBF changes. In conclusion, 2D PC MRI-derived main pulmonary hemodynamic changes reflect changes of RVEF, PBF and 5-month follow-up 6MWD and may be used for future CTEPH patient monitoring after PEA.

show abstract

Section: Discussionmentioning

confidence: 99%

Perioperative CTEPH patient monitoring with 2D phase-contrast MRI reflects clinical, cardiac and pulmonary perfusion changes after pulmonary endarterectomy

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Combined cardiac MRI and time-resolved MRA exam is suitable for detailed treatment response evaluation before and after pulmonary endarterectomy as well as BPA in CTEPH patients. 205,206…”

Section: Section 2: Imaging Adults With Pulmonary Hypertensionmentioning

confidence: 99%

Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI)

Kiely¹,

Levin²,

et al. 2019

View full text Add to dashboard Cite

Pulmonary hypertension (PH) is highly heterogeneous and despite treatment advances it remains a life-shortening condition. There have been significant advances in imaging technologies, but despite evidence of their potential clinical utility, practice remains variable, dependent in part on imaging availability and expertise. This statement summarizes current and emerging imaging modalities and their potential role in the diagnosis and assessment of suspected PH. It also includes a review of commonly encountered clinical and radiological scenarios, and imaging and modeling-based biomarkers. An expert panel was formed including clinicians, radiologists, imaging scientists, and computational modelers. Section editors generated a series of summary statements based on a review of the literature and professional experience and, following consensus review, a diagnostic algorithm and 55 statements were agreed. The diagnostic algorithm and summary statements emphasize the key role and added value of imaging in the diagnosis and assessment of PH and highlight areas requiring further research.

show abstract

“…CMR also plays a role in CTEPH treatment response assessment [69,70]. Septal myocardial T 1 mapping is elevated in CTEPH patients [63] and reduces after treatment with balloon pulmonary angioplasty [63,71].…”

Section: Myocardial T 1 and Extracellular Volume Mappingmentioning

confidence: 99%

Cardiac Magnetic Resonance in Pulmonary Hypertension—an Update

Alabed

Garg

Johns

et al. 2020

Curr Cardiovasc Imaging Rep

View full text Add to dashboard Cite

Purpose of Review This article reviews advances over the past 3 years in cardiac magnetic resonance (CMR) imaging in pulmonary hypertension (PH). We aim to bring the reader up-to-date with CMR applications in diagnosis, prognosis, 4D flow, strain analysis, T1 mapping, machine learning and ongoing research. Recent Findings CMR volumetric and functional metrics are now established as valuable prognostic markers in PH. This imaging modality is increasingly used to assess treatment response and improves risk stratification when incorporated into PH risk scores. Emerging techniques such as myocardial T1 mapping may play a role in the follow-up of selected patients. Myocardial strain may be used as an early marker for right and left ventricular dysfunction and a predictor for mortality. Machine learning has offered a glimpse into future possibilities. Ongoing research of new PH therapies is increasingly using CMR as a clinical endpoint. Summary The last 3 years have seen several large studies establishing CMR as a valuable diagnostic and prognostic tool in patients with PH, with CMR increasingly considered as an endpoint in clinical trials of PH therapies. Machine learning approaches to improve automation and accuracy of CMR metrics and identify imaging features of PH is an area of active research interest with promising clinical utility.

show abstract

Cardio-pulmonary MRI for detection of treatment response after a single BPA treatment session in CTEPH patients

Cited by 31 publications

References 40 publications

Perioperative CTEPH patient monitoring with 2D phase-contrast MRI reflects clinical, cardiac and pulmonary perfusion changes after pulmonary endarterectomy

Perioperative CTEPH patient monitoring with 2D phase-contrast MRI reflects clinical, cardiac and pulmonary perfusion changes after pulmonary endarterectomy

Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI)

Cardiac Magnetic Resonance in Pulmonary Hypertension—an Update

Contact Info

Product

Resources

About