Cardiogenic shock: The main cause of mortality in acute aluminum phosphide poisoning

Mehrpour, Omid; Gurjar, Mohan

doi:10.4103/ijccm.ijccm_97_17

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…3 Cardiovascular toxicity, which can lead to cardiogenic shock and severe acidosis, is responsible for the majority of clinical symptoms. 27 According to previous reports, the lethal dose for a 70 kg subject is between 150 and 500 mg. 28 All acutely AlP-poisoned patients admitted to the ICU of the Poison Control Center of Ain-shams University Hospitals who met the inclusion criteria were included in the current study. Patients were randomly divided into three groups to determine the efficacy of adding any additional treatment to the poison center's supportive care.…”

Section: Discussionmentioning

confidence: 99%

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Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial

et al. 2023

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Aluminum phosphide (AlP) poisoning is a serious medical emergency with a high mortality rate. The absence of an exact antidote for AlP poisoning necessitates the quest for alternative treatment options. The study sought to assess the efficacy of adding L-carnitine or medicated paraffin oil to the conventional approach of treatment employed in cases of acute AlP poisoning. We conducted a 1 year, randomized, controlled, parallel-group, single-blind clinical study. 96 individuals with acute AlP poisoning were randomly assigned to one of three groups. The standard AlP therapy was administered to all groups according to the Poison Control Center guidelines at the Ain-Shams University hospitals. All patients underwent a medical history review, clinical examination, and laboratory tests. The outcomes were assessed. The participants in the study groups had mean ages ranging from 25.6 to 26.3 years. The cases analyzed were evenly distributed between genders, with the majority originating from rural areas. The average delay time varied from 2.9 to 4.2 h. All patients in the study reported ingesting AlP during suicide attempts. 12 hours after admission, many clinical and biochemical data improved in both intervention groups including cytochrome c oxidase, caspase-3, caspase-9, catalase, and superoxide dismutase. The intervention groups required significantly less mechanical ventilation and had a lower mortality rate than the control group. Decontamination with paraffin oil could be advantageous for reducing the severity of AlP poisoning, improving prognosis, and lowering the mortality rate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial

et al. 2023

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“…Furthermore, it does not involve a single organ, leading to multiple organ failure [16]. The effects of poisoning include damages to the heart, lungs, kidneys, and liver, as well as symptoms, such as cardiac arrhythmias, acidosis, and pulmonary edema [17,18]. Heart failure, arrhythmia, seizures, coma, and the delayed onset of liver and kidney toxicity may also occur [18].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Acute Aluminum Phosphide Poisoning by Aloe Vera Syrup: A Case Report

Shakeri

Soroosh

Shakeri

et al. 2021

IJMTFM

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Background: Aluminum phosphide, known as rice pill in Iran, is a very effective pesticide for commercial and industrial ‎use. The high lethality of Aluminum phosphide is due to Phosphine gas (PH3) which is released by its ‎reaction with water. One of the most important properties of aluminum phosphide, which despite being ‎very lethal to almost all living creatures, still makes it one of the most widely used pesticides, is its very ‎high yield, ease of use, and, most importantly, the absence of residues in products after application; while ‎its exposure to the human body is associated with high mortality.‎ Case Presentation: In this article, we reported the successful treatment of rice pill-induced poisoning in a 30-year-old man using a novel approach. Accordingly, we used sodium bicarbonate (50 ccs) and aloe vera syrup (1-2 L), followed by olive oil (150 cc olive oil was given every 2 hours). Conclusion: While numerous studies recommend observing patient conditions as the treatment approach, our presented case was a successful experience of treating acute aluminum phosphide poisoning.

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A study of the predictive factors of mortality in acute poisoning with aluminum phosphide with special reference to echocardiography and SOFA score

Sheta

El-Banna

Elmeguid

et al. 2019

Environ Sci Pollut Res

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Cardiogenic shock: The main cause of mortality in acute aluminum phosphide poisoning

Cited by 8 publications

References 8 publications

Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial

Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial

Successful Treatment of Acute Aluminum Phosphide Poisoning by Aloe Vera Syrup: A Case Report

A study of the predictive factors of mortality in acute poisoning with aluminum phosphide with special reference to echocardiography and SOFA score

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