Cardiolipin in myocardial ischaemia-reperfusion injury: From molecular mechanisms to clinical strategies

Xing, Yun; Xie, Sai-Yang; Deng, Wei; Tang, Qi-Zhu

doi:10.1016/j.biopha.2024.116936

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116936

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Cardiolipin in myocardial ischaemia-reperfusion injury: From molecular mechanisms to clinical strategies

Yun Xing,

Sai-Yang Xie,

Wei Deng

et al.

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2024

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Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury

Ding,

Su,

Shan

et al. 2024

Sci Rep

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Brown adipose tissue (BAT) plays a critical role in regulating cardiovascular homeostasis through the secretion of adipokines, such as fibroblast growth factor 21 (FGF21). Dexmedetomidine (DEX) is a selective α2-adrenergic receptor agonist with a protection against myocardial ischemia/reperfusion injury (MI/RI). It remains largely unknown whether or not BAT-derived FGF21 is involved in DEX-induced cardioprotection in the context of MI/RI. Herein, we demonstrated that DEX alleviated MI/RI and improved heart function through promoting the release of FGF21 from interscapular BAT (iBAT). Surgical iBAT depletion or supplementation with a FGF21 neutralizing antibody attenuated the beneficial effects of DEX. AMPK/PGC1α signaling-induced fibroblast growth factor 21 (FGF21) release in brown adipocytes is required for DEX-mediated cardioprotection since blockade of the AMPK/PGC1α axis weakened the salutary effects of DEX. Co-culture experiments showed that DEX-induced FGF21 from brown adipocytes increased the resistance of cardiomyocytes to hypoxia/reoxygenation (H/R) injury via modulating the Keap1/Nrf2 pathway. Our results provided robust evidence that the BAT-cardiomyocyte interaction is required for DEX cardioprotection, and revealed an endocrine role of BAT in DEX-mediating protection of hearts against MIRI.

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Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury

Ding,

Su,

Shan

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

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Cardiolipin in myocardial ischaemia-reperfusion injury: From molecular mechanisms to clinical strategies

Cited by 1 publication

References 154 publications

Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury

Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury

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