Cardiological Syndrome X: Diagnosis and Intensive Care

Широких, Ю. В.; Кузнецов, С. И.; Шаповалова, Н. В.

doi:10.15360/1813-9779-2007-4-83-87

Cited by 1 publication

(1 citation statement)

References 6 publications

(6 reference statements)

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“…According to Tagliavini et al (1992) specific dopamine antagonists (I-sulpiride) was able to limit ischemia- and reperfusion-induced myocardial damage [ 91 ]. Later clinical works showed the beneficial effects of sulpiride on the patients with MI which manifested itself in the decrease in the number of anginal attacks and their severity [ 92 ]. Thus, based on the data of the above studies and the similarity of the sulpiride and the L-17 compound according to the analysis of the affinity spectra, the authors were able to assume that the administration of L-17 compound will reduce the stress response and improve the course of stress-related coronary heart diseases and MI [ 88 ].…”

Section: Methodsmentioning

confidence: 99%

Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction

et al. 2018

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This review focuses on the biological action of the compounds from the group of substituted 1,3,4-thiadiazines on stress response and myocardial infarction. The aim of this review is to propose the possible mechanisms of action of 1,3,4-thiadiazines and offer prospectives in the development of new derivatives as therapeutic agents. It is known, that compounds that have biological effects similar to those used as antidepressants can down-regulate the secretion of proinflammatory cytokines, up-regulate the release of anti-inflammatory ones and affect cell recruitment, which allows them to be considered immunomodulators as well. The results of pharmacological evaluation, in silico studies, and in vivo experiments of several compounds from the group of substituted 1,3,4-thiadiazines with antidepressant properties are presented. It is proposed that the cardioprotective effects of substituted 1,3,4-thiadiazines might be explained by the peculiarities of their multi-target action: the ability of the compounds to interact with various types of receptors and transporters of dopaminergic, serotonergic and acetylcholinergic systems and to block the kinase signal pathway PI3K-AKT. The described effects of substituted 1,3,4-thiadiazines suggest that it is necessary to search for a new agents for limiting the peripheral inflammatory/ischemic damage through the entral mechanisms of stress reaction and modifying pro-inflammatory cytokine signaling pathways in the brain.

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Section: Methodsmentioning

confidence: 99%