Cardiometabolic risk factors as apolipoprotein B, triglyceride/HDL-cholesterol ratio and C-reactive protein, in adolescents with and without obesity: cross-sectional study in middle class suburban children

Musso, Carla; Graffigna, Mabel; Soutelo, Jimena; Honfi, Margarita; Ledesma, Laura; Miksztowicz, Verónica; Pazos, Mónica; Márta, Mészáros; Schreier, Laura; Berg, Gabriela

doi:10.1111/j.1399-5448.2010.00710.x

Cited by 65 publications

(38 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, some studies have reported that even in the pediatric population, the TG:HDL-C ratio is related to IR and chronic inflammation (10,12,23). Accordingly with these findings, our results confirm the already reported association between TG:HDL-C ratio, IR status, and chronic inflammation, and highlight the value of the TG:HDL-C Significant values by post-hoc analysis: *3rd tertile vs 1st tertile and † 3rd tertile vs 2nd tertile.…”

Section: Discussionsupporting

confidence: 91%

“…In this study, we showed that the TG:HDL-C ratio is an additional independent factor associated with cIMT, therefore providing a further line of evidence for a role of the TG:HDL-C ratio in the cardiovascular risk that was able to discriminate subjects with more marked signs of early atherosclerosis as indicated by higher values of cIMT. It needs to be acknowledged that in our study population, values of the TG:HDL-C ratio were not particularly high when compared with previous studies performed in obese youth (10,23). However, our study population was made only of prepubertal and Caucasian children, and this could explain differences in TG:HDL-C compared with other studies, where also adolescents and a mixture of ethnic groups were studied.…”

Section: Clinical Studymentioning

confidence: 65%

See 1 more Smart Citation

Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in obese prepubertal children

Giorgis

Marcovecchio

Giovanni

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To investigate whether there is an association of the triglyceride-to-HDL cholesterol (TG:HDL-C) ratio with cardiovascular risk factors and early signs of vascular damage in obese prepubertal children. Design and methods: In 50 obese (27 boys, 7.8G1.4 years) and 37 normal-weight (20 boys; 7.3G1.5 years) prepubertal children, anthropometric measurements, oxidative stress markers (urinary isoprostanes (PGF2a (prostaglandin F2a)), soluble receptor for advanced glycation end-products (sRAGE)) and insulin sensitivity (homeostasis model assessment of insulin resistance (HOMA-IR) and whole-body insulin sensitivity index (WBISI)) were evaluated. Lipids profile was assessed and the TG:HDL-C ratio was calculated. In addition, high-resolution ultrasound was performed to assess carotid intima-media thickness (cIMT). Results: Obese children showed significantly higher values of the TG:HDL-C ratio (1.9G1.1 vs 1.2G0.6, PZ0.002) compared with controls. After dividing the population in tertiles of the TG:HDL-C ratio (!1.04, 1.04-1.67, O1.67), cIMT (PZ0.0003), and HOMA-IR (PZ0.0001) progressively increased from the lower to the upper tertile, whereas WBISI (PZ0.0003) and sRAGE (PZ0.05) progressively decreased. In a regression model, the TG:HDL ratio was significantly and positively associated with cIMT (rZ0.493; PZ0.0005). A cutoff point for TG:HDL-C ratio of 1.12 had 81% sensitivity and 49% specificity in the identification of children with cIMT values in the upper quartile (Area under the curve values from receiver operating characteristic curvesZ0.633G0.065, PZ0.045). Conclusion: This study confirms the reliability of the TG:HDL-C ratio as a useful marker of cardiovascular risk. Interestingly, our results underline that the TG:HDL-C ratio is directly related with early signs of vascular damage already present in prepubertal children.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Clinical Studymentioning

confidence: 65%

Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in obese prepubertal children

Giorgis

Marcovecchio

Giovanni

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…In a large series of 26000 overweight children, concentrations of one or more of the lipids were abnormal in 32%: total cholesterol in 14.1%, LDL-C in 15.8%, HDL-C in 11.1%, and triglycerides in 14.3% of those in whom data were available. [53] In a series of 943 school-going adolescents, Musso et al [68] reported significant differences in the levels of triglycerides (73 mg/dl vs 90 mg/dl; P<0.001), and HDL-C (52 mg/dl vs 47 mg/dl; P<0.001) between non-overweight and overweight groups.…”

Section: Dyslipidemiamentioning

confidence: 99%

Rising Incidence of Overweight and Obesity among Children and Adolescents in India

Shokeen¹,

Aeri²

2017

IJLSSR

View full text Add to dashboard Cite

ABSTRACT-The rising incidence of overweight and obesity among children and adolescents has become a cause of concern for India. Overweight/Obesity is an independent risk factor of cardiovascular diseases (CVDs) but it needs to be addressed seriously. Research has shown that modifiable and environmental factors along with genetics triggers the risk of cardiovascular diseases quite early in childhood threatening the health prospects of adults. It is crucial to address the causes of overweight/obesity like physical inactivity, unhealthy eating, lack of knowledge and awareness and impact of media and advertising. Clustering of cardiovascular risk factors like high blood pressure, hyperglycemia, abdominal obesity, high triglycerides in children and adolescents is an alarming sign. In order to dodge this serious public health crisis in near future we need to curb the prevailing risk factors of overweight/obesity. A holistic approach to tackle the obesity epidemic with an array of activities from policy making to program implementation, community education to individual knowledge and skill development is required. We need to promote healthy eating and lifestyle modifications in childhood and adolescents to prevent CVD risk in adulthood.

show abstract

“…Previous research has demonstrated its positive associations with adverse cardiometabolic risk factor profiles, metabolic syndrome and prediction of incident T2DM or its complications (Di Bonito et al, 2012;He et al, 2012;Cordero et al, 2008;Musso et al, 2011;Zoppini et al, 2011;Gaziano et al, 1997;Giannini et al, 2011;Bittner et al, 2009;Li et al, 2008;Quijada et al, 2008;McLaughlin et al, 2003;Fan et al, 2007). This may occur as the triglyceride-to-HDL cholesterol ratio demonstrates an association with insulin resistance (Giannini et al, 2011;Li et al, 2008;Quijada et al, 2008;McLaughlin et al, 2003;Fan et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…The triglyceride-to-HDL cholesterol ratio has been investigated recently for various potential clinical uses in adult and paediatric populations (Di Bonito et al, 2012;He et al, 2012;Cordero et al, 2008;Musso et al, 2011;Zoppini et al, 2011;Gaziano et al, 1997;Giannini et al, 2011;Bittner et al, 2009;Li et al, 2008;Quijada et al, 2008;McLaughlin et al, 2003;Fan et al, 2007). Previous research has demonstrated its positive associations with adverse cardiometabolic risk factor profiles, metabolic syndrome and prediction of incident T2DM or its complications (Di Bonito et al, 2012;He et al, 2012;Cordero et al, 2008;Musso et al, 2011;Zoppini et al, 2011;Gaziano et al, 1997;Giannini et al, 2011;Bittner et al, 2009;Li et al, 2008;Quijada et al, 2008;McLaughlin et al, 2003;Fan et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Can vitamin D replacement reduce insulin resistance in South Asians with vitamin D deficiency?

Davies¹

2012

http://isrctn.org/>

View full text Add to dashboard Cite

BackgroundThe incidence of Type 2 Diabetes Mellitus (T2DM) is increasing rapidly, therefore there is a need to detect this disease earlier and more efficiently, and also to identify novel risk factors that may aid both its detection and prevention.Aims: 1) To discuss the benefits and disadvantages of using HbA1c for diagnosis of T2DM and impaired glucose regulation (IGR).2) To explore the impact on prevalence of using HbA1c to detect T2DM and IGR in global and local populations.3) To determine if diagnostic cut-points are equivalent in different ethnic groups 4) To determine the use of the triglyceride-to-HDL ratio and its association with insulin resistance and whether statins and liver enzymes predict T2DM. 5) To investigate if Vitamin D deficiency has a role in the prevention of T2DM by designing a 6 month randomised controlled trial on vitamin D replacement.Key findings: 1) Using HbA1c for diagnosis has some logistical advantages over glucose testing, but may not detect the same people as having T2DM or IGR.2) In Leicestershire, using HbA1c will increase numbers of people with T2DM and IGR. On global level, there will be regional variation on the effect on prevalence.3) HbA1c, fasting and two hour plasma glucose are independently higher in South Asians (SA). Complications of T2DM may begin earlier in SA.4) The triglyceride-to-HDL ratio associates with insulin resistance in Europeans and SA men but not women. Statin therapy reduces the risk of incident T2DM.Liver enzymes predict T2DM in Europeans but not SA.

show abstract

Cardiometabolic risk factors as apolipoprotein B, triglyceride/HDL-cholesterol ratio and C-reactive protein, in adolescents with and without obesity: cross-sectional study in middle class suburban children

Abstract: Even when the frequency of OB, OW, and MS in adolescents was low, those subjects presented an atherogenic lipoprotein. These findings emphasize the importance to evaluate cardiovascular risk factors in adolescents to assess strategies to prevent future disease.

Cited by 65 publications

References 25 publications

Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in obese prepubertal children

Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in obese prepubertal children

Rising Incidence of Overweight and Obesity among Children and Adolescents in India

Can vitamin D replacement reduce insulin resistance in South Asians with vitamin D deficiency?

Contact Info

Product

Resources

About