Cardiometabolic risk factors in obese individuals and the risk of incident diabetes mellitus in 12-year prospective study

Мустафина, С. В.; Винтер, Д. А.; Рымар, О. Д.; Щербакова, Л. В.; Sazonova, Olga V.; Малютина, С. К.

doi:10.52727/2078-256x-2021-17-52-61

Cited by 3 publications

(3 citation statements)

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“…Нарушение липидного обмена и, в частности, гиперХС подтверждает АО как один из основных факторов риска формирования ишемической болезни сердца (ИБС) у молодых лиц. По данным статистики, ИБС до наступления менопаузы у женщин встречается реже в сравнении с мужчинами аналогичного возраста, тем не менее в более старшем возрасте заболеваемость ИБС и смертность от нее встречаются чаще в женской популяции [10]. Подобные статистические выводы могут иметь объяснение благодаря результатам данной работы: наличие соотносимой распространенности гиперХС среди мужчин и женщин с АО, но более высокие показатели уровня ХС у мужчин во многом объясняют более высокие риски формирования ИБС до 45 лет именно в мужской популяции.…”

Section: Discussionunclassified

“…Дополнительным фактором кардиометаболических рисков у пациентов с АО является наличие сопутствующей патологии, развитие которой в данной популяции было оценена в ряде работ [10][11][12]. С.В.…”

Section: Discussionunclassified

“…Мустафина и соавторы продемонстрировали влияние АО и гипергликемии натощак как одних из основных предикторов развития сахарного диабета 2 типа. Также авторы данного исследования показали отсутствие вероятности появления заболевания у лиц без АО даже при наличии других компонентов метаболического синдрома, в то время как АО повышает риск развития сахарного диабета 2 типа в 2 раза при каждом из компонентов [10]. Учитывая высокую распространенность АО как компонента метаболического синдрома у лиц в г. Новосибирске [1], можно прийти к выводу о более высоком сердечно-сосудистом риске пациентов данного региона и о необхо-димости проведения превентивных терапевтических мероприятий, включающих скрининги, диспансерные осмотры и назначение гиполипидемической терапии.…”

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Prevalence of hypercholesterolemia in young people under 45 years old with abdominal obesity in Novosibirsk

Spiridonov

Денисова

Ragino

2022

jour

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The study was devoted to the study of the prevalence of hypercholesterolemia (hyper-Chol) and hypercholesterolemia of low density lipoproteins (hyper-LDL-C) against the background of abdominal obesity (AO) in a population aged 25–44 years in Novosibirsk. Material and methods. A crosssectional survey of the population aged 25–44 years in Novosibirsk (Russia) was carried out. 1415 people were examined, including 670 men (47.3 %) and 745 women (52.7 %), pregnant women or being on maternity leave were not included in the study). All subjects were assessed for the presence of AO, hyper-Chol and hyper-LDL-C. Results. Individuals with AO had higher average values of total cholesterol and LDL cholesterol. The prevalence of hyper-Chol in individuals with AO was 1.3 times higher and hyper-LDL-C – 1.2 times higher than in individuals without AO. In women with AO, the prevalence of hyper-Chol was 1.2 times higher and hyper-LDL-C – 1.3 times higher than in women without AO. In men with AO, the prevalence of hyper-Chol was 1.4 times higher and hyper-LDL-C – 1.2 times higher than in men without AO. When conducting logistic regression analysis, it was found that in a young population under 45 years of age, abdominal obesity was significantly associated with the presence of atherogenic hypercholesterolemia in both sexes. In men, significant associations of AO with both hyper-Chol and hyper-LDL-C were noted, in women – only with hyper-LDL-C. Conclusions. A population study of young people (25–44 years old) revealed associations of atherogenic hypercholesterolemia with abdominal obesity.

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Prevalence of hypercholesterolemia in young people under 45 years old with abdominal obesity in Novosibirsk

Spiridonov

Денисова

Ragino

2022

jour

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Behavioral and social risk factors for metabolically unhealthy obesity: data form a 12-year prospective study in the Russian population

et al. 2022

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Aim. To study the contribution of behavioral and social risk factors to the development of metabolically unhealthy obesity (MUO) according to a prospective study in the Russian population.Material and methods. From the HAPPIE project, 3197 people aged 45-69 years with a body mass index ≥30 kg/m2 were selected, who had all the necessary parameters for obesity phenotype determination. The prospective analysis included the first (2003-2005) and third screenings (2015-2017). A subsample was formed (n=1275; 276 men — 22%, 999 women — 78%). The mean follow-up period was 12,4 years. IDF criteria (2005) were taken for analysis.Results. Men with a metabolically healthy obesity (MHO) phenotype most often have a secondary and higher education, while women with MHO — vocational and secondary education. In women, secondary education was most often noted. Among persons with obesity, both men and women are more often not single, while having MUO as follows: 56,8% and 34,2%, respectively. Men and women have a low-intensity activity, regardless of the obesity phenotype. The prevalence of smoking in the present time does not differ in the MHO and MUO groups. Metabolically healthy women consume more alcohol than those with MUO. In men with sedentary lifestyle and fasting hyperglycemia, the risk of MUO over a 12-year follow-up period was significantly higher. In women, the risk of conversion from MHO to MUO is increased when blood pressure (BP) is ≥130/85 mmHg.Conclusion. In the Russian population, the risk of MUO in men increases with a level of physical activity <3 h/week and a blood glucose level ≥6,1 mmol/l; in women, only BP ≥130/85 mm Hg contributes to the development of MUO.

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Prognostic Significance of Electrocardiographic Parameters Associated With Metabolic Changes in the Myocardium (Literature Review)

Kuzminykh,

Ragino

2024

Kompleks. probl. serdečno-sosud. zabol.

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Highlights The main ECG parameters associated with cardiovascular mortality in metabolic cardiomyopathy are P-wave changes, QT prolongation, ECG signs of left ventricular hypertrophy, depression and ST segment elevation, T-wave changes. These simple ECG markers are valuable signs of an unfavorable prognosis in patients with myocardial metabolic disorders. AbstractCardiovascular diseases (CVD) are the leading cause of death globally, one of the initial manifestations of these diseases are metabolic changes in the myocardium. Risk stratification in a young population makes would make it possible to timely identify such conditions and prevent their development, as well as their further progression. Electrocardiography is an effective, reliable, accessible and inexpensive method used in clinical practice and research. The aim of this article was to review electrocardiographic (ECG) features associated with manifestations of myocardial metabolic disorders, the mechanisms underlying these associations, and to briefly describe the main research findings in this area and consider the implications for clinical practice. The material and methods were literature sources analyzing metabolic changes in the myocardium and their electrophysiological manifestations, the following databases were used to search for relevant articles: elibrary.ru, pubmed.ncbi.nlm.nih.gov, researchgate.net. The results of the analysis showed that the main changes in ECG parameters associated with cardiovascular mortality in metabolic cardiomyopathy are P-wave changes, QT prolongation, ECG signs of left ventricular hypertrophy, depression and ST segment elevation, T-wave changes. Thus, simple ECGs-markers remain valuable indicators of an adverse prognosis for patients with metabolic disorders of the myocardium.

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Cardiometabolic risk factors in obese individuals and the risk of incident diabetes mellitus in 12-year prospective study

Cited by 3 publications

References 30 publications

Prevalence of hypercholesterolemia in young people under 45 years old with abdominal obesity in Novosibirsk

Prevalence of hypercholesterolemia in young people under 45 years old with abdominal obesity in Novosibirsk

Behavioral and social risk factors for metabolically unhealthy obesity: data form a 12-year prospective study in the Russian population

Prognostic Significance of Electrocardiographic Parameters Associated With Metabolic Changes in the Myocardium (Literature Review)

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