Cardiometabolic risk factors in primary centred and rotator cuff-related shoulder osteoarthritis: a comparative study

Abstract

BackgroundRisk factors for shoulder osteoarthritis (SOA) have been poorly studied. SOA has two anatomical subtypes: primary centred SOA (centred SOA) and rotator cuff-related OA (non-centred SOA). We examined whether cardiometabolic risk factors are preferentially associated with centred than mechanical-induced non-centred SOA.MethodsThis 2004–2012 retrospective multicentric study included patients with SOA. Data on clinical characteristics, especially cardiometabolic risk factors, were collected. We compared patients with radiographic-centred and non-centred SOA and tested the association between cardiometabolic risk factors and subtypes of SOA.ResultsWe included 147 patients (101 women (68.7%); mean age 75.8±10 years); 99 had centred SOA. As compared with patients with non-centred SOA, those with centred SOA were older (77.5±9 vs 72.4±11 years; p=0.004) with no difference in cardiometabolic disturbances or their accumulation. Multivariable analyses indicated that older age was independently associated with centred SOA (OR 1.06;95% CI 1.02 to 1.1; p=0.004), and cardiovascular diseases were less associated with this subtype (OR 0.27; 95% CI 0.089 to 0.824; p=0.02) than with the non-centred one.ConclusionCardiometabolic risk factors were not more prevalent with primary centred than rotator cuff-related SOA. They may participate in the pathophysiology of both SOA subtypes through cartilage and tendon disruption.

Is there an association between metabolic syndrome and rotator cuff-related shoulder pain? A systematic review

“…After exclusions, 36 studies required the full text to be assessed. Out of these, 30 studies were excluded (23 studies had incomplete cardiometabolic details available to establish a MetS definition, 5 studies had no shoulder pain data and 2 studies did not meet participant criteria), resulting in 6 studies42 43 55 66–68 for inclusion in this review.…”

“…The total number of individuals across the studies was 8259 (mean age 50.9 years), of which 1187 were people experiencing RCRSP. Five studies recruited participants from health centres or hospitals 42 43 55 67 68. Applegate et al 66 recruited participants from 17 diverse production facilities, including food processing, manufacturing, assembly lines and office jobs.…”

The effects of hyperlipidemia on rotator cuff diseases: a systematic review

“…Two studies were excluded because of review article or editorial article. Two studies were added after reviewing the reference and citation list of each included study [ 19 , 20 ]. Finally, 16 studies were included in this systematic review [ 8 , 12 , 17 , 19 – 31 ].…”

“…Six studies were conducted in European countries [ 12 , 19 , 20 , 22 , 23 , 28 ], six in North American countries [ 17 , 21 , 25 , 26 , 29 , 30 ], and four in Asian countries [ 8 , 24 , 27 , 31 ]. Three studies were prospective cohort study [ 21 , 23 , 25 ], seven were retrospective cohort study [ 8 , 17 , 20 , 24 , 26 , 27 , 29 ], two were case-control study [ 12 , 31 ], two were cross-sectional study [ 19 , 30 ], one was case series [ 28 ], and one was retrospective observational study [ 22 ]. Of the 16 studies analyzed, ten were comparative and analyzed using the 24-point scale; the remaining six non-comparative studies were analyzed on the 16-point scale.…”

The Role of Vascular Remodeling in the Formation of Structural Phenotypes of Osteoarthritis

“…С другой стороны, процесс ремоделирования сосу-дистой стенки связан с выработкой вазоактивных веществ таких как оксида азота, эндотелиально-го фактора роста сосудов, трансформирующего фактора роста, провоспалительных цитокинов, адипокинов. Указанные биологически активные вещества являются известными факторами пато-генеза остеоартрита [13], что также указывает на имеющиеся взаимосвязи между системным сосу-дистым ремоделированием и ОА.…”