Cardiometabolic risk factors in women experienced thrombosis at a young age

Abstract

Objective: to assess the presence of cardiometabolic risk factors in women who have suffered arterial or venous thrombosis at a young age. Material and methods. The type of study is a "cross-section" based on a prospective observational study. The main group included 49 women aged 18-44 who had undergone instrumental^ verified arterial or venous thrombosis at least 1 year ago. The median follow-up was 80.3 months [50.1; 96.2] months. The control group included 24 practically healthy female volunteers in the same age range. All patients underwent a comprehensive laboratory examination, bioimpedance measurement and oscillographic sphygmography Results. Women with a history of thrombosis had higher levels of LDL cholesterol (3.4±0.8 vs 2.6±0.6 mmol/L); lipoprotein (a) (90.6±7.4 vs56.9±6.5 mg/dl) and adiponectin (10.4±4.3 vs 8.2±3.6 mcg/ml); lower levels of cholesterol HDL(1.5±0.4 vs 1.8±0.4 mmol/l) (0.049>p>0.001). The incidence of visceral obesity in this group was 76.2% vs 37.5% in the control group (p<0.001). The total number of cardiovascular risk factors in these patients averaged 2.7±0.1 vs 1.4±0.2 in the control group (p=0.0001). In the main group, an increase in the cardio-ankle vascular index was revealed 6.85±0.95 vs 6.20±0.51 (p=0.044) in women without thrombosis. Only in the group with thrombosis patients have a decrease in LPK0.9 and an increase in the CAVI index>8 (18,5 vs 0% in the control; p=0.025). Conclusion. Young women with a history of thrombosis are characterized by a more burdened profile of cardiometabolic risk factors, a higher incidence of visceral obesity and increased vascular wall stiffness compared with women without thrombosis of the same age group.