What is already known on this topic? Filipino American adults have a higher risk of developing type 2 diabetes than White adults, other Asian adults, and residents of the Philippines despite their relatively low body weight.What is added by this report? Among Filipino American adults, the prevalence of overweight and obesity increased from the first to the 3rd generation, whereas rates of type 2 diabetes were only significantly higher in the 2nd generation than the 1st generation.What are the implications for public health practice? Overweight and obesity, diet quality, and other lifestyle factors may explain the higher type 2 diabetes rates among 2nd-generation Filipino American adults. Culturally appropriate interventions are needed to reduce lifestyle factors that result in high rates of type 2 diabetes among Filipino immigrants and their descendants.