Cardiomyocyte and Heart Failure

Nakano, Shintaro; Muramatsu, Toshihiro; Nishimura, Shigeyuki; Senbonmatsu, Takaaki

doi:10.5772/47772

Cited by 3 publications

(2 citation statements)

References 77 publications

(69 reference statements)

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“…The main product of the RAAS is Ang-II, which has compensatory systemic effects that, if they persist, can exacerbate HF. This is because, in HF, Ang-II is stimulated to maintain cardiac output through increased vasoconstriction, salt retention, contractility, and the activation of inflammatory mediators [1,20,21]. The neuroendocrine pathological mechanisms of HF are regulated by the sympathetic nervous system and are linked to the RAAS [21].…”

Section: Discussionmentioning

confidence: 99%

FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility

et al. 2023

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Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis of HF with preserved ejection fraction (HFpEF) is still unclear, impeding the implementation of effective treatments. FK506-binding protein like (FKBPL) and its therapeutic peptide mimetic, AD-01, are critical mediators of angiogenesis and inflammation. Thus, in this study, we investigated—for the first time—FKBPL’s role in the pathogenesis and as a biomarker of HFpEF. In vitro models of cardiac hypertrophy following exposure to a hypertensive stimulus, angiotensin-II (Ang-II, 100 nM), and/or AD-01 (100 nM), for 24 and 48 h were employed as well as human plasma samples from people with different forms of HFpEF and controls. Whilst the FKBPL peptide mimetic, AD-01, induced cardiomyocyte hypertrophy in a similar manner to Ang-II (p < 0.0001), when AD-01 and Ang-II were combined together, this process was abrogated (p < 0.01–0.0001). This mechanism appears to involve a negative feedback loop related to FKBPL (p < 0.05). In human plasma samples, FKBPL concentration was increased in HFpEF compared to controls (p < 0.01); however, similar to NT-proBNP and Gal-3, it was unable to stratify between different forms of HFpEF: acute HFpEF, chronic HFpEF and hypertrophic cardiomyopathy (HCM). FKBPL may be explored for its biomarker and therapeutic target potential in HFpEF.

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Section: Discussionmentioning

confidence: 99%

FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility

et al. 2023

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“…The number of cardiomyocytes usually decreases during HF (Nakano et al, 2012). Although the cause of this loss has not been fully clarified, it is known that cardiomyocytes are exposed to many different stressors in HF (Richardson et al, 1996;Chien, 1999).…”

Section: Regulation Of Ctgf In Response To Er Stressmentioning

confidence: 99%

Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes

Singh¹

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The Quantum-Mechanical Sensitivity of Cell Hydration in Mammals

Nikoghosyan¹,

Narinyan²,

Heqimyan³

et al. 2018

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The elucidation of the mechanism on the biological effects of weak chemical and physical factors on cells and organism is one of the modern problems in life sciences. According to the Receptor Theory of Prof. Bernard Katz the impact of the biological substances on cells is realized through the activation of ligand-gated ion channels in the membrane. However, this theory doesn't provide a satisfactory explanation on the similar biological effects of extremely low concentrations of different chemical substances, which are unable to activate the ionic channels in the membrane and have non-linear dose-dependent effect on cells. Previously we have suggested that the metabolic control of cell hydration serves as a universal quantum-mechanical sensor for different weak physical and chemical signals. For supporting this hypothesis, in this article the comparative study of the effects of low concentrations of both cold (non-radioactive) and [ 3 H]-ouabain (specific inhibitor for Na + /K +-ATPase) on the hydration in different tissues of rats has been performed. The obtained data have shown that cold and [ 3 H]-ouabain have different effects on cell hydration and such a difference depends on the initial metabolic state of tissues. On the basis of our previous and present results it is suggested that such a quantum-mechanical sensitivity of cell hydration is realized through the cyclic-nucleotides-dependent Na + /Ca 2+ exchange, having a crucial role in the metabolic regulation of cell hydration.

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Cardiomyocyte and Heart Failure

Cited by 3 publications

References 77 publications

FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility

FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility

Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes

The Quantum-Mechanical Sensitivity of Cell Hydration in Mammals

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